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Chrna2 cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) [ Mus musculus (house mouse) ]

Gene ID: 110902, updated on 25-Nov-2021

Summary

Official Symbol
Chrna2provided by MGI
Official Full Name
cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)provided by MGI
Primary source
MGI:MGI:87886
See related
Ensembl:ENSMUSG00000022041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acra2; Acra-2; BC011490
Expression
Biased expression in genital fat pad adult (RPKM 6.8), ovary adult (RPKM 1.4) and 6 other tissues See more
Orthologs
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Genomic context

See Chrna2 in Genome Data Viewer
Location:
14 D1; 14 34.36 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66370685..66390397)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66133236..66152948)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66759797..66771785)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 2 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene epoxide hydrolase 2, cytoplasmic Neighboring gene PTK2 protein tyrosine kinase 2 beta Neighboring gene predicted gene, 52098 Neighboring gene predicted gene, 52099

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC18795

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables acetylcholine-gated cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
 
enables extracellular ligand-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables quaternary ammonium group binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to acetylcholine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nicotine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neuronal acetylcholine receptor subunit alpha-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144803.2NP_659052.1  neuronal acetylcholine receptor subunit alpha-2 precursor

    See identical proteins and their annotated locations for NP_659052.1

    Status: VALIDATED

    Source sequence(s)
    AC126272
    Consensus CDS
    CCDS27219.1
    UniProtKB/Swiss-Prot
    Q91X60
    Related
    ENSMUSP00000022620.10, ENSMUST00000022620.11
    Conserved Domains (2) summary
    TIGR00860
    Location:15505
    LIC; Cation transporter family protein
    cd19015
    Location:36242
    LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    66370685..66390397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518436.4XP_006518499.1  neuronal acetylcholine receptor subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_006518499.1

    UniProtKB/Swiss-Prot
    Q91X60
    Conserved Domains (2) summary
    TIGR00860
    Location:15505
    LIC; Cation transporter family protein
    cd19015
    Location:36242
    LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)
  2. XM_006518435.3XP_006518498.1  neuronal acetylcholine receptor subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_006518498.1

    UniProtKB/Swiss-Prot
    Q91X60
    Conserved Domains (2) summary
    TIGR00860
    Location:15505
    LIC; Cation transporter family protein
    cd19015
    Location:36242
    LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)
  3. XM_006518434.3XP_006518497.1  neuronal acetylcholine receptor subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_006518497.1

    UniProtKB/Swiss-Prot
    Q91X60
    Related
    ENSMUSP00000145896.2, ENSMUST00000206455.2
    Conserved Domains (2) summary
    TIGR00860
    Location:15505
    LIC; Cation transporter family protein
    cd19015
    Location:36242
    LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)
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