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Cds2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 [ Mus musculus (house mouse) ]

Gene ID: 110911, updated on 8-Aug-2021

Summary

Official Symbol
Cds2provided by MGI
Official Full Name
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2provided by MGI
Primary source
MGI:MGI:1332236
See related
Ensembl:ENSMUSG00000058793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI854580; D2Wsu127; D2Wsu127e; 5730450N06Rik; 5730460C18Rik
Expression
Ubiquitous expression in cerebellum adult (RPKM 33.8), frontal lobe adult (RPKM 33.6) and 28 other tissues See more
Orthologs
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Genomic context

See Cds2 in Genome Data Viewer
Location:
2 F2; 2 64.15 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132105068..132153970)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132253338..132312050)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (132088993..132137777)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene expressed sequence AV099323 Neighboring gene proliferating cell nuclear antigen Neighboring gene predicted gene, 46766 Neighboring gene prokineticin receptor 2 Neighboring gene RIKEN cDNA 4921508D12 gene Neighboring gene VISTA enhancer mm1391

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidate cytidylyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidate cytidylyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycosylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in lipid droplet formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phototransduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidate cytidylyltransferase 2
Names
CDP-DAG synthase 2
CDP-DG synthase 2
CDP-diglyceride pyrophosphorylase 2
CDP-diglyceride synthase 2
CTP:phosphatidate cytidylyltransferase 2
NP_001277968.1
NP_001277969.1
NP_619592.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291039.1NP_001277968.1  phosphatidate cytidylyltransferase 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AI854580, AK017677, AK049257, AK147541, BQ572878, CD351907, CD540005
    Consensus CDS
    CCDS71150.1
    UniProtKB/Swiss-Prot
    Q99L43
    UniProtKB/TrEMBL
    A2AMQ5, Q8BX08
    Related
    ENSMUSP00000086886.5, ENSMUST00000089461.11
    Conserved Domains (1) summary
    cl21502
    Location:88407
    CTP_transf_1; Cytidylyltransferase family
  2. NM_001291040.1NP_001277969.1  phosphatidate cytidylyltransferase 2 isoform c

    See identical proteins and their annotated locations for NP_001277969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK050589, BU610248, CJ112406
    Consensus CDS
    CCDS79850.1
    UniProtKB/TrEMBL
    Q6PBC0
    Related
    ENSMUSP00000105786.2, ENSMUST00000110158.8
    Conserved Domains (2) summary
    pfam04718
    Location:4486
    ATP-synt_G; Mitochondrial ATP synthase g subunit
    cl21502
    Location:69129
    CTP_transf_1; Cytidylyltransferase family
  3. NM_138651.7NP_619592.1  phosphatidate cytidylyltransferase 2 isoform a

    See identical proteins and their annotated locations for NP_619592.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI854580, AK017677, AK147541, BQ572878, CD351907, CJ112406
    Consensus CDS
    CCDS16772.1
    UniProtKB/Swiss-Prot
    Q99L43
    Related
    ENSMUSP00000099470.5, ENSMUST00000103181.11
    Conserved Domains (1) summary
    cl21502
    Location:105424
    CTP_transf_1; Cytidylyltransferase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    132105068..132153970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_866210.2 RNA Sequence

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