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LOC111365173 HNF4 motif-containing MPRA enhancer 1/2 [ Homo sapiens (human) ]

Gene ID: 111365173, updated on 18-May-2021

Summary

Gene symbol
LOC111365173
Gene description
HNF4 motif-containing MPRA enhancer 1/2
Gene type
biological region
Feature type(s)
regulatory: enhancer, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was predicted to be a cell type-specific enhancer based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by high-throughput massively parallel reporter assays (MPRAs) in liver carcinoma HepG2 cells. This enhancer contains a conserved motif for the HNF4 activator. Mutation of this motif results in reduced enhancer activity. [provided by RefSeq, Nov 2017]
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Genomic context

See LOC111365173 in Genome Data Viewer
Location:
3q
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (122365644..122365788)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122084491..122084635)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 23 Neighboring gene cystatin A Neighboring gene mitochondrial matrix import factor 23 Neighboring gene family with sequence similarity 162 member A Neighboring gene WDR5B divergent transcript Neighboring gene WD repeat domain 5B Neighboring gene karyopherin subunit alpha 1

Genomic regions, transcripts, and products

General gene information

Other Names

  • HNF4 activator MPRA enhancer 1
  • HNF4 activator MPRA enhancer 2
  • massively parallel reporter assay enhancer 1/2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055760.1 

    Range
    101..245
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    122365644..122365788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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