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LOC111465017 HNF1 motif-containing MPRA enhancer 259 [ Homo sapiens (human) ]

Gene ID: 111465017, updated on 10-Oct-2023

Summary

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Gene symbol
LOC111465017
Gene description
HNF1 motif-containing MPRA enhancer 259
Gene type
biological region
Feature type(s)
regulatory: enhancer, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was predicted to be a cell type-specific enhancer based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by high-throughput massively parallel reporter assays (MPRAs) in liver carcinoma HepG2 cells. This enhancer contains a conserved motif for the HNF1 activator. Mutation of this motif results in reduced enhancer activity. [provided by RefSeq, Nov 2017]
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Genomic context

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Location:
7p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (30255064..30255208)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (30392760..30392904)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30294680..30294824)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:30208325-30209524 Neighboring gene uncharacterized LOC105375217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25807 Neighboring gene ribosomal protein S27 pseudogene 16 Neighboring gene uncharacterized LOC124901607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25808 Neighboring gene uncharacterized LOC105375218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18065 Neighboring gene microRNA 550a-1 Neighboring gene microRNA 550b-1 Neighboring gene zinc and ring finger 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:30358457-30358625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25810 Neighboring gene Sharpr-MPRA regulatory region 6335 Neighboring gene uncharacterized protein DKFZp586I1420

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay. Kheradpour P, et al. Genome Res, 2013 May. PMID 23512712, Free PMC Article
  2. Mapping and analysis of chromatin state dynamics in nine human cell types. Ernst J, et al. Nature, 2011 May 5. PMID 21441907, Free PMC Article
  3. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • HNF1 activator MPRA enhancer 259
  • massively parallel reporter assay enhancer 259

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055921.1 

    Range
    101..245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    30255064..30255208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    30392760..30392904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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