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Igh immunoglobulin heavy chain complex [ Mus musculus (house mouse) ]

Gene ID: 111507, updated on 13-Jul-2021

Summary

Official Symbol
Ighprovided by MGI
Official Full Name
immunoglobulin heavy chain complexprovided by MGI
Primary source
MGI:MGI:96442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Summary:Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. The RefSeq represents the IGH locus from C57BL/6. Several V and D segments in C57BL/6 are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Jul 2008]
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Genomic context

See Igh in Genome Data Viewer
Location:
12 F1- F2; 12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113222388..115973574, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113258768..116009954, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (114496979..117248165, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene transmembrane protein 121 Neighboring gene predicted gene, 25622 Neighboring gene immunoglobulin heavy constant gamma 2C Neighboring gene immunoglobulin heavy constant gamma 2B Neighboring gene immunoglobulin heavy constant alpha Neighboring gene Immunoglobulin heavy constant epsilon Neighboring gene immunoglobulin heavy constant gamma 1 (G1m marker) Neighboring gene FUS interacting protein (serine-arginine rich) 1 pseudogene Neighboring gene immunoglobulin heavy diversity 4-1 Neighboring gene transducin-like enhancer of split 6 pseudogene Neighboring gene transducin-like enhancer of split 6 pseudogene Neighboring gene Immunoglobulin heavy constant gamma 3 Neighboring gene immunoglobulin heavy diversity 5-5 Neighboring gene immunoglobulin heavy diversity 2-8 Neighboring gene immunoglobulin heavy diversity 5-6 Neighboring gene immunoglobulin heavy diversity 3-2 Neighboring gene immunoglobulin heavy diversity 5-4 Neighboring gene immunoglobulin heavy diversity 5-8 Neighboring gene immunoglobulin heavy diversity 2-7 Neighboring gene immunoglobulin heavy diversity 2-6 Neighboring gene immunoglobulin heavy diversity 5-7 Neighboring gene immunoglobulin heavy diversity 5-3 Neighboring gene immunoglobulin heavy diversity 2-5 Neighboring gene immunoglobulin heavy diversity 5-2 Neighboring gene immunoglobulin heavy diversity 2-4 Neighboring gene immunoglobulin heavy diversity 2-3 Neighboring gene immunoglobulin heavy diversity 6-2 Neighboring gene immunoglobulin heavy diversity 1-1 Neighboring gene immunoglobulin heavy diversity 6-1 Neighboring gene immunoglobulin heavy joining 2 Neighboring gene immunoglobulin heavy joining 1 Neighboring gene immunoglobulin heavy joining 4 Neighboring gene immunoglobulin heavy joining 3 Neighboring gene immunoglobulin heavy diversity 3-1 Neighboring gene immunoglobulin heavy diversity 5-1 Neighboring gene immunoglobulin heavy constant delta Neighboring gene a disintegrin and metallopeptidase domain 6B Neighboring gene immunoglobulin heavy constant mu Neighboring gene immunoglobulin heavy variable V5-1 Neighboring gene immunoglobulin heavy variable 2-1 Neighboring gene immunoglobulin heavy variable 5-2 Neighboring gene immunoglobulin heavy variable V5-3 Neighboring gene a disintegrin and metallopeptidase domain 6A Neighboring gene immunoglobulin heavy variable 2-2 Neighboring gene immunoglobulin heavy variable 5-4 Neighboring gene immunoglobulin heavy variable V6-1 Neighboring gene immunoglobulin heavy variable 2-3 Neighboring gene immunoglobulin heavy variable V5-5 Neighboring gene immunoglobulin heavy variable 5-6 Neighboring gene immunoglobulin heavy variable 5-10 Neighboring gene immunoglobulin heavy variable V5-7 Neighboring gene immunoglobulin heavy variable 5-12-4 Neighboring gene immunoglobulin heavy variable V5-11 Neighboring gene immunoglobulin heavy variable V5-8 Neighboring gene immunoglobulin heavy variable 5-9-1 Neighboring gene immunoglobulin heavy variable V2-4 Neighboring gene immunoglobulin heavy variable 5-9 Neighboring gene immunoglobulin heavy variable 5-12 Neighboring gene predicted gene 9517 Neighboring gene immunoglobulin heavy variable 2-5 Neighboring gene immunoglobulin heavy variable 2-9-1 Neighboring gene immunoglobulin heavy variable 2-6-8 Neighboring gene immunoglobulin heavy variable 2-6 Neighboring gene ribosomal protein L26, pseudogene 3 Neighboring gene immunoglobulin heavy variable V5-13 Neighboring gene immunoglobulin heavy variable 5-15 Neighboring gene immunoglobulin heavy variable 5-16 Neighboring gene immunoglobulin heavy variable 2-7 Neighboring gene immunoglobulin heavy variable 5-17 Neighboring gene immunoglobulin heavy variable V5-18 Neighboring gene immunoglobulin heavy variable V5-19 Neighboring gene predicted gene 7003 Neighboring gene immunoglobulin heavy variable V2-8 Neighboring gene immunoglobulin heavy variable 2-9 Neighboring gene immunoglobulin heavy variable 7-1 Neighboring gene immunoglobulin heavy variable 14-1 Neighboring gene immunoglobulin heavy variable 7-2 Neighboring gene immunoglobulin heavy variable 11-1 Neighboring gene immunoglobulin heavy variable 4-1 Neighboring gene immunoglobulin heavy variable 14-2 Neighboring gene immunoglobulin heavy variable 3-1 Neighboring gene immunoglobulin heavy variable V11-2 Neighboring gene immunoglobulin heavy variable V4-2 Neighboring gene immunoglobulin heavy variable V14-3 Neighboring gene immunoglobulin heavy variable 3-2 Neighboring gene immunoglobulin heavy variable 16-1 Neighboring gene immunoglobulin heavy variable V12-1 Neighboring gene immunoglobulin heavy variable V6-2 Neighboring gene immunoglobulin heavy variable V12-2 Neighboring gene immunoglobulin heavy variable 9-1 Neighboring gene immunoglobulin heavy variable V9-2 Neighboring gene immunoglobulin heavy variable V15-1 Neighboring gene immunoglobulin heavy variable 14-4 Neighboring gene immunoglobulin heavy variable V9-3 Neighboring gene immunoglobulin heavy variable 7-3 Neighboring gene immunoglobulin heavy variable V3-3 Neighboring gene immunoglobulin heavy variable 7-4 Neighboring gene immunoglobulin heavy variable 13-1 Neighboring gene immunoglobulin heavy variable V3-4 Neighboring gene immunoglobulin heavy variable 3-5 Neighboring gene RAD23b homolog pseudogene Neighboring gene immunoglobulin heavy variable V5-21 Neighboring gene immunoglobulin heavy variable 3-6 Neighboring gene immunoglobulin heavy variable 9-4 Neighboring gene immunoglobulin heavy variable V3-7 Neighboring gene immunoglobulin heavy variable 13-2 Neighboring gene immunoglobulin heavy variable V3-8 Neighboring gene immunoglobulin heavy variable V12-3 Neighboring gene immunoglobulin heavy variable V8-1 Neighboring gene immunoglobulin heavy variable V1-1 Neighboring gene predicted gene, 53771 Neighboring gene immunoglobulin heavy variable 6-3 Neighboring gene microRNA 7094-1 Neighboring gene immunoglobulin heavy variable V6-4 Neighboring gene immunoglobulin heavy variable V6-5 Neighboring gene immunoglobulin heavy variable 6-6 Neighboring gene microRNA 7094-2 Neighboring gene immunoglobulin heavy variable 10-1 Neighboring gene immunoglobulin heavy variable V6-7 Neighboring gene immunoglobulin heavy variable V10-2 Neighboring gene immunoglobulin heavy variable V8-2 Neighboring gene immunoglobulin heavy variable 1-2 Neighboring gene immunoglobulin heavy variable V10-3 Neighboring gene immunoglobulin heavy variable V1-3 Neighboring gene immunoglobulin heavy variable 1-4 Neighboring gene immunoglobulin heavy variable V10-4 Neighboring gene immunoglobulin heavy variable V1-5 Neighboring gene immunoglobulin heavy variable V15-2 Neighboring gene immunoglobulin heavy variable V1-6 Neighboring gene immunoglobulin heavy variable V1-7 Neighboring gene immunoglobulin heavy variable V1-8 Neighboring gene immunoglobulin heavy variable V1-17-1 Neighboring gene immunoglobulin heavy variable V1-10 Neighboring gene immunoglobulin heavy variable V1-11 Neighboring gene immunoglobulin heavy variable V1-12 Neighboring gene immunoglobulin heavy variable V1-9 Neighboring gene immunoglobulin heavy variable 1-19-1 Neighboring gene immunoglobulin heavy variable V1-13 Neighboring gene immunoglobulin heavy variable 1-14 Neighboring gene immunoglobulin heavy variable 1-15 Neighboring gene immunoglobulin heavy variable 1-21-1 Neighboring gene immunoglobulin heavy variable 1-16 Neighboring gene immunoglobulin heavy variable 1-17 Neighboring gene immunoglobulin heavy variable V1-18 Neighboring gene immunoglobulin heavy variable V1-19 Neighboring gene predicted gene, 46322 Neighboring gene immunoglobulin heavy variable V1-20 Neighboring gene immunoglobulin heavy variable V1-21 Neighboring gene immunoglobulin heavy variable 1-22 Neighboring gene immunoglobulin heavy variable V1-23 Neighboring gene immunoglobulin heavy variable V1-24 Neighboring gene immunoglobulin heavy variable 1-25 Neighboring gene immunoglobulin heavy variable 1-26 Neighboring gene predicted gene, 40899 Neighboring gene immunoglobulin heavy variable V1-27 Neighboring gene immunoglobulin heavy variable 1-28 Neighboring gene immunoglobulin heavy variable V1-29 Neighboring gene immunoglobulin heavy variable 1-30 Neighboring gene immunoglobulin heavy variable 1-31 Neighboring gene immunoglobulin heavy variable V1-32 Neighboring gene immunoglobulin heavy variable 1-33 Neighboring gene predicted gene, 34465 Neighboring gene immunoglobulin heavy variable 1-34 Neighboring gene immunoglobulin heavy variable 1-35 Neighboring gene immunoglobulin heavy variable 1-36 Neighboring gene immunoglobulin heavy variable 1-37 Neighboring gene immunoglobulin heavy variable V1-38 Neighboring gene immunoglobulin heavy variable 1-39 Neighboring gene immunoglobulin heavy variable V1-40 Neighboring gene immunoglobulin heavy variable 1-41 Neighboring gene immunoglobulin heavy variable V1-42 Neighboring gene immunoglobulin heavy variable V1-43 Neighboring gene immunoglobulin heavy variable V1-44 Neighboring gene immunoglobulin heavy variable V1-45 Neighboring gene immunoglobulin heavy variable V1-46 Neighboring gene immunoglobulin heavy variable 1-47 Neighboring gene immunoglobulin heavy variable V1-48 Neighboring gene immunoglobulin heavy variable V8-3 Neighboring gene immunoglobulin heavy variable 1-49 Neighboring gene immunoglobulin heavy variable V8-4 Neighboring gene immunoglobulin heavy variable V8-5 Neighboring gene immunoglobulin heavy variable 1-50 Neighboring gene immunoglobulin heavy variable V1-51 Neighboring gene immunoglobulin heavy variable 1-52 Neighboring gene immunoglobulin heavy variable 1-53 Neighboring gene immunoglobulin heavy variable V1-54 Neighboring gene immunoglobulin heavy variable V8-6 Neighboring gene immunoglobulin heavy variable 1-55 Neighboring gene immunoglobulin heavy variable 1-56 Neighboring gene high mobility group box 2 pseudogene Neighboring gene immunoglobulin heavy variable V1-57 Neighboring gene immunoglobulin heavy variable V8-7 Neighboring gene predicted gene, 30948 Neighboring gene high mobility group box 2 pseudogene Neighboring gene immunoglobulin heavy variable 1-62-1 Neighboring gene immunoglobulin heavy variable 1-58 Neighboring gene baculoviral IAP repeat-containing 3 pseudogene Neighboring gene immunoglobulin heavy variable V1-59 Neighboring gene immunoglobulin heavy variable 8-8 Neighboring gene immunoglobulin heavy variable V1-60 Neighboring gene immunoglobulin heavy variable 1-61 Neighboring gene immunoglobulin heavy variable 1-62-2 Neighboring gene immunoglobulin heavy variable V1-62 Neighboring gene immunoglobulin heavy variable 1-62-3 Neighboring gene predicted gene, 30996 Neighboring gene immunoglobulin heavy variable V1-63 Neighboring gene immunoglobulin heavy variable V8-9 Neighboring gene immunoglobulin heavy variable 1-64 Neighboring gene immunoglobulin heavy variable V8-10 Neighboring gene immunoglobulin heavy variable V1-65 Neighboring gene ribosomal protein L7A, pseudogene 2 Neighboring gene high mobility group box 2 pseudogene Neighboring gene immunoglobulin heavy variable V8-11 Neighboring gene high mobility group box 2 pseudogene Neighboring gene immunoglobulin heavy variable 1-66 Neighboring gene immunoglobulin heavy variable V1-67 Neighboring gene immunoglobulin heavy variable V1-68 Neighboring gene immunoglobulin heavy variable 1-69 Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene Neighboring gene immunoglobulin heavy variable V8-12 Neighboring gene cell division cycle 5-like pseudogene Neighboring gene WW domain binding protein 11 pseudogene Neighboring gene immunoglobulin heavy variable 1-70 Neighboring gene microRNA 6388 Neighboring gene immunoglobulin heavy variable 1-71 Neighboring gene predicted gene, 40900 Neighboring gene high mobility group box 2 pseudogene Neighboring gene immunoglobulin heavy variable 1-72 Neighboring gene immunoglobulin heavy variable 8-13 Neighboring gene immunoglobulin heavy variable 1-73 Neighboring gene immunoglobulin heavy variable V1-74 Neighboring gene immunoglobulin heavy variable 8-14 Neighboring gene olfactory receptor 241, pseudogene 1 Neighboring gene immunoglobulin heavy variable 1-75 Neighboring gene immunoglobulin heavy variable 1-76 Neighboring gene immunoglobulin heavy variable V8-15 Neighboring gene immunoglobulin heavy variable V8-16 Neighboring gene high mobility group box 1 pseudogene Neighboring gene high mobility group box 2 pseudogene Neighboring gene immunoglobulin heavy variable 1-77 Neighboring gene immunoglobulin heavy variable 1-78 Neighboring gene immunoglobulin heavy variable 1-79 Neighboring gene immunoglobulin heavy variable 1-80 Neighboring gene immunoglobulin heavy variable 1-81 Neighboring gene immunoglobulin heavy variable 1-82 Neighboring gene olfactory receptor GA_x5J8B7W27DS-1519-2216 Neighboring gene immunoglobulin heavy variable 1-83 Neighboring gene signaling molecule ATTP pseudogene Neighboring gene immunoglobulin heavy variable 1-84 Neighboring gene immunoglobulin heavy variable 1-85 Neighboring gene immunoglobulin heavy variable 1-86 Neighboring gene predicted gene, 53772 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene zinc finger protein 386 (Kruppel-like)

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC6486, MGC6522, MGC6529, MGC6628, MGC6740, MGC28019, MGC36307, MGC68276, MGC68378, MGC102661, MGC102662, MGC103226, MGC118125

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005838.1 

    Range
    11172..2762358 complement
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    113222388..115973574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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