FSTL1 follistatin like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FSTL1provided by HGNC
Official Full Name: follistatin like 1provided by HGNC
Primary source: HGNC:HGNC:3972
See related: Ensembl:ENSG00000163430 MIM:605547; AllianceGenome:HGNC:3972
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FRP; FSL1; OCC1; OCC-1; tsc36; MIR198
Summary: This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Expression: Broad expression in placenta (RPKM 238.4), gall bladder (RPKM 177.0) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q13.33

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (120392293..120450992, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (123111839..123170569, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (120111140..120169839, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FSTL1: A double-edged sword in cancer development.
Title: FSTL1: A double-edged sword in cancer development.
Follistatin-like 1 is a myokine regulating lipid mobilization during endurance exercise and recovery.
Title: Follistatin-like 1 is a myokine regulating lipid mobilization during endurance exercise and recovery.
Analysis of the expression and mechanism of follistatin-like protein 1 in cervical cancer.
Title: Analysis of the expression and mechanism of follistatin‑like protein 1 in cervical cancer.
Role of follistatin-like protein 1 in liver diseases.
Title: Role of follistatin-like protein 1 in liver diseases.
CircPTTG1IP knockdown suppresses rheumatoid arthritis progression by targeting miR-431-5p/FSTL1 axis.
Title: CircPTTG1IP knockdown suppresses rheumatoid arthritis progression by targeting miR-431-5p/FSTL1 axis.
FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2.
Title: FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2.
FOXO1 inhibits FSL-1 regulation of integrin beta6 by blocking STAT3 binding to the integrin beta6 gene promoter.
Title: FOXO1 inhibits FSL-1 regulation of integrin β6 by blocking STAT3 binding to the integrin β6 gene promoter.
Follistatin-like 1 and its paralogs in heart development and cardiovascular disease.
Title: Follistatin-like 1 and its paralogs in heart development and cardiovascular disease.
Effects of acute endurance exercise on follistatin-like 1 and apelin in the circulation and metabolic organs in rats.
Title: Effects of acute endurance exercise on follistatin-like 1 and apelin in the circulation and metabolic organs in rats.
Odd-skipped related 1 plays a tumor suppressor role in ovarian cancer via promoting follistatin-like protein 1 transcription.
Title: Odd-skipped related 1 plays a tumor suppressor role in ovarian cancer via promoting follistatin-like protein 1 transcription.

Submit: New GeneRIF Correction See all GeneRIFs (102)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-77238 (e-PCR)
- UniSTS:82195

SHGC-77232 (e-PCR)
- UniSTS:23095

D3S2939E (e-PCR)
- UniSTS:150922

D3S3330 (e-PCR)
- UniSTS:5554

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic stem cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed

General protein information

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Preferred Names: follistatin-related protein 1

Names: follistatin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007085.5 → NP_009016.1 follistatin-related protein 1 precursor

See identical proteins and their annotated locations for NP_009016.1

Status: REVIEWED

Source sequence(s)

AC063952, AI813946, BC000055, DB289587

Consensus CDS

CCDS2998.1

UniProtKB/Swiss-Prot

A8K523, B4DTT5, D3DN90, Q12841, Q549Z0

Related

ENSP00000295633.3, ENST00000295633.8

Conserved Domains (4) summary

smart00274
Location:31 → 53

FOLN; Follistatin-N-terminal domain-like

smart00280
Location:54 → 98

KAZAL; Kazal type serine protease inhibitors

cd16233
Location:113 → 226

EFh_SPARC_FSTL1; EF-hand, extracellular calcium-binding (EC) motif, found in follistatin-related protein 1 (FRP-1)

cl17735
Location:233 → 271

VWC; von Willebrand factor type C domain