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Egln2 egl-9 family hypoxia-inducible factor 2 [ Mus musculus (house mouse) ]

Gene ID: 112406, updated on 23-Jun-2021

Summary

Official Symbol
Egln2provided by MGI
Official Full Name
egl-9 family hypoxia-inducible factor 2provided by MGI
Primary source
MGI:MGI:1932287
See related
Ensembl:ENSMUSG00000058709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ie; Phd; Ier4; Phd1; SM-2; SM-20; C85656; Hif-p4h; Hif-p4h-1; 0610011A13Rik
Expression
Ubiquitous expression in testis adult (RPKM 271.8), adrenal adult (RPKM 57.2) and 27 other tissues See more
Orthologs
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Genomic context

See Egln2 in Genome Data Viewer
Location:
7 A3; 7 15.83 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26858083..26866227, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27158658..27166802, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (27943677..27951821, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily f, polypeptide 2 Neighboring gene cytochrome P450, family 2, subfamily t, polypeptide 4 Neighboring gene RAB4B, member RAS oncogene family Neighboring gene microRNA 3101 Neighboring gene melanoma inhibitory activity

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC101954

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables oxygen sensor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidyl-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidyl-proline 4-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidyl-proline dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prolyl hydroxylase EGLN2
Names
HIF-PH1
HIF-prolyl hydroxylase 1
HPH-1
falkor
hypoxia-inducible factor prolyl hydroxylase 1
immediate early response 4
prolyl hydroxylase domain-containing protein 1
NP_001344696.1
NP_444438.2
XP_030097849.1
XP_030097850.1
XP_030097851.1
XP_036008464.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357767.1NP_001344696.1  prolyl hydroxylase EGLN2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157553
    Conserved Domains (1) summary
    smart00702
    Location:172266
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
  2. NM_053208.4NP_444438.2  prolyl hydroxylase EGLN2 isoform 1

    See identical proteins and their annotated locations for NP_444438.2

    Status: VALIDATED

    Source sequence(s)
    BC086764, BE993075, CB248412
    Consensus CDS
    CCDS21011.1
    UniProtKB/Swiss-Prot
    Q91YE2
    UniProtKB/TrEMBL
    Q80X29
    Related
    ENSMUSP00000078966.5, ENSMUST00000080058.11
    Conserved Domains (1) summary
    smart00702
    Location:217387
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    26858083..26866227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030241990.1XP_030097850.1  prolyl hydroxylase EGLN2 isoform X2

    Conserved Domains (1) summary
    smart00702
    Location:172266
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
  2. XM_030241991.1XP_030097851.1  prolyl hydroxylase EGLN2 isoform X2

    Conserved Domains (1) summary
    smart00702
    Location:172266
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
  3. XM_030241989.1XP_030097849.1  prolyl hydroxylase EGLN2 isoform X1

    Related
    ENSMUSP00000104019.2, ENSMUST00000108382.2
    Conserved Domains (1) summary
    smart00702
    Location:217387
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
  4. XM_036152571.1XP_036008464.1  prolyl hydroxylase EGLN2 isoform X1

    Conserved Domains (1) summary
    smart00702
    Location:217387
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
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