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DDX19B DEAD-box helicase 19B [ Homo sapiens (human) ]

Gene ID: 11269, updated on 11-Apr-2024

Summary

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Official Symbol
DDX19Bprovided by HGNC
Official Full Name
DEAD-box helicase 19Bprovided by HGNC
Primary source
HGNC:HGNC:2742
See related
Ensembl:ENSG00000157349 MIM:605812; AllianceGenome:HGNC:2742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBP5; RNAh; DDX19
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 16.5), thyroid (RPKM 10.7) and 25 other tissues See more
Orthologs
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Genomic context

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See DDX19B in Genome Data Viewer
Location:
16q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70289767..70335305)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (76100775..76146326)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70323670..70369208)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:70286884-70287384 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70294233-70294475 Neighboring gene exosome component 6 Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70317824-70318022 Neighboring gene RNA, 7SL, cytoplasmic 279, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7671 Neighboring gene Sharpr-MPRA regulatory region 7868 Neighboring gene DDX19A divergent transcript Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:70366483-70367682 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70379806-70380424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70380425-70381042 Neighboring gene DEAD-box helicase 19A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11055 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70421141-70421825 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11057 Neighboring gene uncharacterized LOC124903707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11059 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70458653-70459478

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SUMOylation modulates the function of DDX19 in mRNA export. Banerjee P, et al. J Cell Sci, 2022 Feb 15. PMID 35080244
  2. Dbp5/DDX19 between Translational Readthrough and Nonsense Mediated Decay. Beißel C, et al. Int J Mol Sci, 2020 Feb 6. PMID 32041247, Free PMC Article
  3. RNA helicase DDX19 stabilizes ribosomal elongation and termination complexes. Mikhailova T, et al. Nucleic Acids Res, 2017 Feb 17. PMID 28180304, Free PMC Article
  4. The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch. Collins R, et al. J Biol Chem, 2009 Apr 17. PMID 19244245, Free PMC Article
  5. Identification and characterization of a gene coding a novel isoform of DEAD-box protein. Yin L, et al. Reprod Fertil Dev, 2002. PMID 12219940

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUMOylation modulates the function of DDX19 in mRNA export.
    Title: SUMOylation modulates the function of DDX19 in mRNA export.
  2. Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF-DDX19B interaction.
    Title: Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF-DDX19B interaction.
  3. Emerging molecular functions and novel roles for the DEAD-box protein Dbp5/DDX19 in gene expression.
    Title: Emerging molecular functions and novel roles for the DEAD-box protein Dbp5/DDX19 in gene expression.
  4. Dbp5/DDX19 between Translational Readthrough and Nonsense Mediated Decay.
    Title: Dbp5/DDX19 between Translational Readthrough and Nonsense Mediated Decay.
  5. Results found that Nup159 did not accelerate ADP release, while Gle1 actually slowed it independently of Mg(2+) which is not consistent with Nup159 acting as a nucleotide exchange factor to promote ADP release and Dbp5 ATPase cycling. Instead, in the presence of Nup159, the interaction between Gle1 and ADP-bound Dbp5 was found more reduced, suggesting that Nup159 alters the Dbp5-Gle1 to aid Gle1 release from Dbp5.
    Title: Nup159 Weakens Gle1 Binding to Dbp5 But Does Not Accelerate ADP Release.
  6. These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism.
    Title: Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect.
  7. DDX19 interacts with pre-termination complexes (preTCs) in a nucleotide-dependent manner. Furthermore, DDX19 increases the efficiency of termination complex (TC) formation and the peptide release in the presence of eukaryotic release factors. DDX19 also stabilizes ribosome complexes with translation elongation factors eEF1 and eEF2.
    Title: RNA helicase DDX19 stabilizes ribosomal elongation and termination complexes.
  8. Ddx19 is an RNA export factor required for nuclear import of the SRF coactivator MKL1
    Title: RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1.
  9. Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export.
    Title: Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export.
  10. Results describe the crystal structures of human DDX19, a DEXD/H-box protein, in its open and closed cleft conformations.
    Title: The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity TAS
Traceable Author Statement
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus TAS
Traceable Author Statement
more info
 PubMed 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
part_of nuclear pore TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX19B
Names
ATP-dependent RNA helicase DDX19
DEAD (Asp-Glu-Ala-As) box polypeptide 19B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
DEAD box protein 19B
DEAD-box RNA helicase DEAD5
DEAD-box protein 5
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (Dbp5, yeast, homolog)
dead box protein 5 homolog
yeast Dbp5 homolog
NP_001014449.1
NP_001014451.1
NP_001244101.1
NP_001244102.1
NP_001244103.1
NP_001244104.1
NP_001350867.1
NP_009173.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014449.3 → NP_001014449.1  ATP-dependent RNA helicase DDX19B isoform 3

    See identical proteins and their annotated locations for NP_001014449.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, BC003626, BC010008, BI756088, DC385044
    Consensus CDS
    CCDS42187.1
    UniProtKB/TrEMBL
    Q69YM2
    Related
    ENSP00000377267.2, ENST00000393657.6
    Conserved Domains (1) summary
    COG0513
    Location:1 → 369
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  2. NM_001014451.3 → NP_001014451.1  ATP-dependent RNA helicase DDX19B isoform 2

    See identical proteins and their annotated locations for NP_001014451.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, AL136639, BC003626, BI756088, DC385044
    Consensus CDS
    CCDS32475.1
    UniProtKB/TrEMBL
    B4DS24
    Related
    ENSP00000348271.3, ENST00000355992.7
    Conserved Domains (1) summary
    COG0513
    Location:101 → 447
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  3. NM_001257172.2 → NP_001244101.1  ATP-dependent RNA helicase DDX19B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC012184, AK302107
    Consensus CDS
    CCDS58478.1
    UniProtKB/TrEMBL
    B4DS24
    Related
    ENSP00000392639.3, ENST00000451014.7
    Conserved Domains (3) summary
    COG0513
    Location:106 → 452
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:281 → 416
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:105 → 270
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001257173.2 → NP_001244102.1  ATP-dependent RNA helicase DDX19B isoform 3

    See identical proteins and their annotated locations for NP_001244102.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, AK301938
    Consensus CDS
    CCDS42187.1
    UniProtKB/TrEMBL
    Q69YM2
    Related
    ENSP00000456757.1, ENST00000568625.5
    Conserved Domains (1) summary
    COG0513
    Location:1 → 369
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  5. NM_001257174.2 → NP_001244103.1  ATP-dependent RNA helicase DDX19B isoform 3

    See identical proteins and their annotated locations for NP_001244103.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, AF353720
    Consensus CDS
    CCDS42187.1
    UniProtKB/TrEMBL
    Q69YM2
    Related
    ENSP00000456574.1, ENST00000563392.5
    Conserved Domains (1) summary
    COG0513
    Location:1 → 369
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  6. NM_001257175.2 → NP_001244104.1  ATP-dependent RNA helicase DDX19B isoform 5

    See identical proteins and their annotated locations for NP_001244104.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, AK296868, DC385044
    UniProtKB/TrEMBL
    B4DL69, Q69YM2
    Conserved Domains (2) summary
    COG0513
    Location:9 → 327
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cl28899
    Location:1 → 145
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  7. NM_001363938.1 → NP_001350867.1  ATP-dependent RNA helicase DDX19B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC012184
    Consensus CDS
    CCDS86540.1
    UniProtKB/TrEMBL
    H3BQK0, Q2NL95
    Related
    ENSP00000455813.1, ENST00000563206.5
    Conserved Domains (1) summary
    COG0513
    Location:95 → 483
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  8. NM_007242.7 → NP_009173.1  ATP-dependent RNA helicase DDX19B isoform 1

    See identical proteins and their annotated locations for NP_009173.1

    Status: REVIEWED

    Source sequence(s)
    AC012184
    Consensus CDS
    CCDS10888.1
    UniProtKB/Swiss-Prot
    B3KNE9, B4DXS6, E7EMK4, Q6FIB7, Q6IAE0, Q96KE7, Q9H0U0, Q9UMR2
    UniProtKB/TrEMBL
    A0A0U4B4U6, Q53G16
    Related
    ENSP00000288071.7, ENST00000288071.11
    Conserved Domains (2) summary
    cd18787
    Location:307 → 443
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cl28899
    Location:75 → 303
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    70289767..70335305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    76100775..76146326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UMR2.1 GenPept UniProtKB/Swiss-Prot:Q9UMR2

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