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ATXN2L ataxin 2 like [ Homo sapiens (human) ]

Gene ID: 11273, updated on 7-Apr-2024

Summary

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Official Symbol
ATXN2Lprovided by HGNC
Official Full Name
ataxin 2 likeprovided by HGNC
Primary source
HGNC:HGNC:31326
See related
Ensembl:ENSG00000168488 MIM:607931; AllianceGenome:HGNC:31326
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A2D; A2LG; A2LP; A2RP
Summary
This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 66.0), spleen (RPKM 26.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
16p11.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28822999..28837232)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (29103578..29117815)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28834320..28848553)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein S15a pseudogene 33 Neighboring gene uncharacterized LOC124903672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28833599-28834335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7313 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28853164-28853321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10645 Neighboring gene microRNA 4721 Neighboring gene MPRA-validated peak2552 silencer Neighboring gene Tu translation elongation factor, mitochondrial Neighboring gene SH2B adaptor protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10646 Neighboring gene Sharpr-MPRA regulatory region 4004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28885274-28885774

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ATXN2L upregulated by epidermal growth factor promotes gastric cancer cell invasiveness and oxaliplatin resistance. Lin L, et al. Cell Death Dis, 2019 Feb 20. PMID 30787271, Free PMC Article
  2. Identification and expression of the gene for human ataxin-2-related protein on chromosome 16. Figueroa KP, et al. Exp Neurol, 2003 Dec. PMID 14769358
  3. PRMT1-mediated arginine methylation controls ATXN2L localization. Kaehler C, et al. Exp Cell Res, 2015 May 15. PMID 25748791
  4. Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. Pulst SM, et al. Nat Genet, 1996 Nov. PMID 8896555
  5. Ataxin-2-like is a regulator of stress granules and processing bodies. Kaehler C, et al. PLoS One, 2012. PMID 23209657, Free PMC Article

See all (142) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATXN2L promotes cell invasiveness and oxaliplatin resistance and can be upregulated by EGF via PI3K/Akt signaling.
    Title: ATXN2L upregulated by epidermal growth factor promotes gastric cancer cell invasiveness and oxaliplatin resistance.
  2. ATXN2L associates with the protein arginine-N-methyltransferase 1 (PRMT1).
    Title: PRMT1-mediated arginine methylation controls ATXN2L localization.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children.
  4. cellular ataxin-2 concentration is important for the assembly of stress granules and P-bodies, ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6
    Title: Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
EBI GWAS Catalog
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Common variants at five new loci associated with early-onset inflammatory bowel disease.
EBI GWAS Catalog
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated ataxin 2-like protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag Interaction of HIV-1 Gag with ataxin 2-like (ATXN2L) is identified in a series of six affinity purification/mass spectrometry screens PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress granule assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ataxin-2-like protein
Names
ataxin 2 related protein
ataxin-2 domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308230.2 → NP_001295159.1  ataxin-2-like protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS76850.1
    UniProtKB/TrEMBL
    H3BUF6
    Related
    ENSP00000457613.1, ENST00000564304.5
    Conserved Domains (3) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:122 → 191
    SM-ATX; Ataxin 2 SM domain

  2. NM_001387166.1 → NP_001374095.1  ataxin-2-like protein isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667 → 947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  3. NM_001387167.1 → NP_001374096.1  ataxin-2-like protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS10640.1
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661 → 941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  4. NM_001387168.1 → NP_001374097.1  ataxin-2-like protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS10640.1
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661 → 941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  5. NM_001387169.1 → NP_001374098.1  ataxin-2-like protein isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667 → 947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  6. NM_001387170.1 → NP_001374099.1  ataxin-2-like protein isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667 → 947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  7. NM_001387171.1 → NP_001374100.1  ataxin-2-like protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:815 → 946
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  8. NM_001387172.1 → NP_001374101.1  ataxin-2-like protein isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667 → 947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  9. NM_001387173.1 → NP_001374102.1  ataxin-2-like protein isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398 → 943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  10. NM_001387174.1 → NP_001374103.1  ataxin-2-like protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661 → 941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  11. NM_001387175.1 → NP_001374104.1  ataxin-2-like protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661 → 941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  12. NM_001387176.1 → NP_001374105.1  ataxin-2-like protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661 → 941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  13. NM_001387177.1 → NP_001374106.1  ataxin-2-like protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661 → 941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  14. NM_001387178.1 → NP_001374107.1  ataxin-2-like protein isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Related
    ENST00000563314.5
    Conserved Domains (3) summary
    PHA03247
    Location:398 → 943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  15. NM_001387179.1 → NP_001374108.1  ataxin-2-like protein isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 720
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:637 → 917
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  16. NM_001387180.1 → NP_001374109.1  ataxin-2-like protein isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398 → 936
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  17. NM_001387181.1 → NP_001374110.1  ataxin-2-like protein isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (5) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:815 → 946
    PRK10263; DNA translocase FtsK; Provisional
    pfam03154
    Location:740 → 1059
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  18. NM_001387182.1 → NP_001374111.1  ataxin-2-like protein isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    PHA03247
    Location:674 → 1060
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  19. NM_001387183.1 → NP_001374112.1  ataxin-2-like protein isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398 → 943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  20. NM_001387184.1 → NP_001374113.1  ataxin-2-like protein isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398 → 943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  21. NM_001387185.1 → NP_001374114.1  ataxin-2-like protein isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 720
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:637 → 917
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  22. NM_001387186.1 → NP_001374115.1  ataxin-2-like protein isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 720
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:785 → 916
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  23. NM_001387187.1 → NP_001374116.1  ataxin-2-like protein isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285

  24. NM_001387188.1 → NP_001374117.1  ataxin-2-like protein isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    PHA03247
    Location:644 → 1013
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:209 → 720
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  25. NM_001387189.1 → NP_001374118.1  ataxin-2-like protein isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667 → 947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  26. NM_001387190.1 → NP_001374119.1  ataxin-2-like protein isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285

  27. NM_001387191.1 → NP_001374120.1  ataxin-2-like protein isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    PHA03247
    Location:398 → 943
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:865 → 1035
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  28. NM_001387192.1 → NP_001374121.1  ataxin-2-like protein isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398 → 943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  29. NM_001387193.1 → NP_001374122.1  ataxin-2-like protein isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667 → 947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  30. NM_001387194.1 → NP_001374123.1  ataxin-2-like protein isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398 → 943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  31. NM_001387195.1 → NP_001374124.1  ataxin-2-like protein isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661 → 941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  32. NM_001387196.1 → NP_001374125.1  ataxin-2-like protein isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661 → 941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  33. NM_001387197.1 → NP_001374126.1  ataxin-2-like protein isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    PHA03247
    Location:650 → 1033
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:209 → 726
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  34. NM_001387198.1 → NP_001374127.1  ataxin-2-like protein isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661 → 941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  35. NM_001387199.1 → NP_001374128.1  ataxin-2-like protein isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 721
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:638 → 918
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  36. NM_001387200.1 → NP_001374129.1  ataxin-2-like protein isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 726
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:643 → 923
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  37. NM_001387202.1 → NP_001374131.1  ataxin-2-like protein isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209 → 720
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:637 → 917
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  38. NM_001387203.1 → NP_001374132.1  ataxin-2-like protein isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PRK10263
    Location:598 → 878
    PRK10263; DNA translocase FtsK; Provisional
    PRK14971
    Location:338 → 489
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  39. NM_001387204.1 → NP_001374133.1  ataxin-2-like protein isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398 → 979
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  40. NM_007245.4 → NP_009176.2  ataxin-2-like protein isoform 1

    See identical proteins and their annotated locations for NP_009176.2

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS10641.1
    UniProtKB/Swiss-Prot
    A8K1R6, B9EGM2, E9PAR9, O95135, Q63ZY4, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q8WWM7, Q99703
    Related
    ENSP00000338718.4, ENST00000336783.9
    Conserved Domains (3) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:122 → 191
    SM-ATX; Ataxin 2 SM domain

  41. NM_017492.4 → NP_059867.3  ataxin-2-like protein isoform 6

    See identical proteins and their annotated locations for NP_059867.3

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS58443.1
    Related
    ENSP00000454516.1, ENST00000570200.5
    Conserved Domains (3) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:122 → 191
    SM-ATX; Ataxin 2 SM domain

  42. NM_145714.3 → NP_663760.1  ataxin-2-like protein isoform 2

    See identical proteins and their annotated locations for NP_663760.1

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS32423.1
    Related
    ENSP00000315650.6, ENST00000325215.10
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:757 → 941
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:122 → 191
    SM-ATX; Ataxin 2 SM domain

  43. NM_148414.3 → NP_680780.1  ataxin-2-like protein isoform 3

    See identical proteins and their annotated locations for NP_680780.1

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS10640.1
    Related
    ENSP00000378917.2, ENST00000395547.6
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661 → 941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  44. NM_148415.3 → NP_680781.1  ataxin-2-like protein isoform 4

    See identical proteins and their annotated locations for NP_680781.1

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS10639.1
    Related
    ENSP00000341459.8, ENST00000340394.12
    Conserved Domains (2) summary
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:122 → 191
    SM-ATX; Ataxin 2 SM domain

  45. NM_148416.3 → NP_680782.1  ataxin-2-like protein isoform 5

    See identical proteins and their annotated locations for NP_680782.1

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS45451.1
    Related
    ENSP00000372133.4, ENST00000382686.8
    Conserved Domains (4) summary
    COG5180
    Location:209 → 744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:757 → 941
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:122 → 191
    SM-ATX; Ataxin 2 SM domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    28822999..28837232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545719.3 → XP_011544021.1  ataxin-2-like protein isoform X1

    See identical proteins and their annotated locations for XP_011544021.1

    Conserved Domains (5) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:815 → 946
    PRK10263; DNA translocase FtsK; Provisional
    pfam03154
    Location:740 → 1094
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:123 → 196
    SM-ATX; Ataxin 2 SM domain

  2. XM_054328429.1 → XP_054184404.1  ataxin-2-like protein isoform X1

  3. XM_006721011.2 → XP_006721074.1  ataxin-2-like protein isoform X4

    See identical proteins and their annotated locations for XP_006721074.1

    Conserved Domains (4) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763 → 948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:122 → 191
    SM-ATX; Ataxin 2 SM domain

  4. XM_047433529.1 → XP_047289485.1  ataxin-2-like protein isoform X4

  5. XM_047433528.1 → XP_047289484.1  ataxin-2-like protein isoform X4

  6. XM_006721012.5 → XP_006721075.1  ataxin-2-like protein isoform X4

    See identical proteins and their annotated locations for XP_006721075.1

    Conserved Domains (4) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763 → 948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:122 → 191
    SM-ATX; Ataxin 2 SM domain

  7. XM_047433527.1 → XP_047289483.1  ataxin-2-like protein isoform X4

  8. XM_005255074.2 → XP_005255131.1  ataxin-2-like protein isoform X3

    Conserved Domains (4) summary
    COG5180
    Location:209 → 750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763 → 948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264 → 326
    LsmAD; LsmAD domain
    pfam14438
    Location:122 → 191
    SM-ATX; Ataxin 2 SM domain

  9. XM_047433530.1 → XP_047289486.1  ataxin-2-like protein isoform X5

  10. XM_047433526.1 → XP_047289482.1  ataxin-2-like protein isoform X2

  11. XM_047433536.1 → XP_047289492.1  ataxin-2-like protein isoform X11

  12. XM_047433533.1 → XP_047289489.1  ataxin-2-like protein isoform X8

  13. XM_047433531.1 → XP_047289487.1  ataxin-2-like protein isoform X6

  14. XM_047433532.1 → XP_047289488.1  ataxin-2-like protein isoform X7

  15. XM_047433535.1 → XP_047289491.1  ataxin-2-like protein isoform X10

  16. XM_047433537.1 → XP_047289493.1  ataxin-2-like protein isoform X12

  17. XM_047433540.1 → XP_047289496.1  ataxin-2-like protein isoform X15

  18. XM_047433534.1 → XP_047289490.1  ataxin-2-like protein isoform X9

  19. XM_047433541.1 → XP_047289497.1  ataxin-2-like protein isoform X16

  20. XM_047433544.1 → XP_047289500.1  ataxin-2-like protein isoform X19

  21. XM_047433542.1 → XP_047289498.1  ataxin-2-like protein isoform X17

  22. XM_047433545.1 → XP_047289501.1  ataxin-2-like protein isoform X20

  23. XM_047433543.1 → XP_047289499.1  ataxin-2-like protein isoform X18

  24. XM_047433538.1 → XP_047289494.1  ataxin-2-like protein isoform X13

  25. XM_047433549.1 → XP_047289505.1  ataxin-2-like protein isoform X23

  26. XM_047433546.1 → XP_047289502.1  ataxin-2-like protein isoform X21

  27. XM_047433539.1 → XP_047289495.1  ataxin-2-like protein isoform X14

  28. XM_047433548.1 → XP_047289504.1  ataxin-2-like protein isoform X22

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    29103578..29117815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379450.1 → XP_054235425.1  ataxin-2-like protein isoform X4

  2. XM_054379455.1 → XP_054235430.1  ataxin-2-like protein isoform X5

  3. XM_054379462.1 → XP_054235437.1  ataxin-2-like protein isoform X11

  4. XM_054379464.1 → XP_054235439.1  ataxin-2-like protein isoform X12

  5. XM_054379442.1 → XP_054235417.1  ataxin-2-like protein isoform X1

  6. XM_054379443.1 → XP_054235418.1  ataxin-2-like protein isoform X1

  7. XM_054379441.1 → XP_054235416.1  ataxin-2-like protein isoform X1

  8. XM_054379444.1 → XP_054235419.1  ataxin-2-like protein isoform X1

  9. XM_054379446.1 → XP_054235421.1  ataxin-2-like protein isoform X25

  10. XM_054379454.1 → XP_054235429.1  ataxin-2-like protein isoform X4

  11. XM_054379453.1 → XP_054235428.1  ataxin-2-like protein isoform X4

  12. XM_054379451.1 → XP_054235426.1  ataxin-2-like protein isoform X4

  13. XM_054379452.1 → XP_054235427.1  ataxin-2-like protein isoform X4

  14. XM_054379448.1 → XP_054235423.1  ataxin-2-like protein isoform X3

  15. XM_054379449.1 → XP_054235424.1  ataxin-2-like protein isoform X26

  16. XM_054379447.1 → XP_054235422.1  ataxin-2-like protein isoform X2

  17. XM_054379459.1 → XP_054235434.1  ataxin-2-like protein isoform X8

  18. XM_054379456.1 → XP_054235431.1  ataxin-2-like protein isoform X27

  19. XM_054379457.1 → XP_054235432.1  ataxin-2-like protein isoform X28

  20. XM_054379461.1 → XP_054235436.1  ataxin-2-like protein isoform X31

  21. XM_054379445.1 → XP_054235420.1  ataxin-2-like protein isoform X24

  22. XM_054379474.1 → XP_054235449.1  ataxin-2-like protein isoform X42

  23. XM_054379472.1 → XP_054235447.1  ataxin-2-like protein isoform X40

  24. XM_054379473.1 → XP_054235448.1  ataxin-2-like protein isoform X41

  25. XM_054379467.1 → XP_054235442.1  ataxin-2-like protein isoform X35

  26. XM_054379468.1 → XP_054235443.1  ataxin-2-like protein isoform X36

  27. XM_054379463.1 → XP_054235438.1  ataxin-2-like protein isoform X32

  28. XM_054379460.1 → XP_054235435.1  ataxin-2-like protein isoform X30

  29. XM_054379471.1 → XP_054235446.1  ataxin-2-like protein isoform X39

  30. XM_054379470.1 → XP_054235445.1  ataxin-2-like protein isoform X38

  31. XM_054379466.1 → XP_054235441.1  ataxin-2-like protein isoform X34

  32. XM_054379475.1 → XP_054235450.1  ataxin-2-like protein isoform X43

  33. XM_054379465.1 → XP_054235440.1  ataxin-2-like protein isoform X33

  34. XM_054379458.1 → XP_054235433.1  ataxin-2-like protein isoform X29

  35. XM_054379469.1 → XP_054235444.1  ataxin-2-like protein isoform X37

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WWM7.2 GenPept UniProtKB/Swiss-Prot:Q8WWM7

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