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ATXN2L ataxin 2 like [ Homo sapiens (human) ]

Gene ID: 11273, updated on 25-Nov-2021

Summary

Official Symbol
ATXN2Lprovided by HGNC
Official Full Name
ataxin 2 likeprovided by HGNC
Primary source
HGNC:HGNC:31326
See related
Ensembl:ENSG00000168488 MIM:607931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A2D; A2LG; A2LP; A2RP
Summary
This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 66.0), spleen (RPKM 26.9) and 25 other tissues See more
Orthologs
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Genomic context

See ATXN2L in Genome Data Viewer
Location:
16p11.2
Exon count:
26
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (28822999..28837237)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28834320..28848553)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear pore complex interacting protein family member B9 Neighboring gene uncharacterized LOC105379464 Neighboring gene pro-apoptotic WT1 regulator pseudogene 2 Neighboring gene ribosomal protein S15a pseudogene 33 Neighboring gene microRNA 4721 Neighboring gene Tu translation elongation factor, mitochondrial Neighboring gene SH2B adaptor protein 1 Neighboring gene Sharpr-MPRA regulatory region 4004

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
GeneReviews: Not available
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
GeneReviews: Not available
Common variants at five new loci associated with early-onset inflammatory bowel disease.
GeneReviews: Not available
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated ataxin 2-like protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag Interaction of HIV-1 Gag with ataxin 2-like (ATXN2L) is identified in a series of six affinity purification/mass spectrometry screens PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress granule assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ataxin-2-like protein
Names
ataxin 2 related protein
ataxin-2 domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308230.2NP_001295159.1  ataxin-2-like protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS76850.1
    UniProtKB/TrEMBL
    H3BUF6
    Related
    ENSP00000457613.1, ENST00000564304.5
    Conserved Domains (3) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  2. NM_001387166.1NP_001374095.1  ataxin-2-like protein isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  3. NM_001387167.1NP_001374096.1  ataxin-2-like protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  4. NM_001387168.1NP_001374097.1  ataxin-2-like protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  5. NM_001387169.1NP_001374098.1  ataxin-2-like protein isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  6. NM_001387170.1NP_001374099.1  ataxin-2-like protein isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  7. NM_001387171.1NP_001374100.1  ataxin-2-like protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:815946
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  8. NM_001387172.1NP_001374101.1  ataxin-2-like protein isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  9. NM_001387173.1NP_001374102.1  ataxin-2-like protein isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  10. NM_001387174.1NP_001374103.1  ataxin-2-like protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  11. NM_001387175.1NP_001374104.1  ataxin-2-like protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  12. NM_001387176.1NP_001374105.1  ataxin-2-like protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  13. NM_001387177.1NP_001374106.1  ataxin-2-like protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  14. NM_001387178.1NP_001374107.1  ataxin-2-like protein isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Related
    ENST00000563314.5
    Conserved Domains (3) summary
    PHA03247
    Location:398943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  15. NM_001387179.1NP_001374108.1  ataxin-2-like protein isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209720
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:637917
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  16. NM_001387180.1NP_001374109.1  ataxin-2-like protein isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398936
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  17. NM_001387181.1NP_001374110.1  ataxin-2-like protein isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (5) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:815946
    PRK10263; DNA translocase FtsK; Provisional
    pfam03154
    Location:7401059
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  18. NM_001387182.1NP_001374111.1  ataxin-2-like protein isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    PHA03247
    Location:6741060
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  19. NM_001387183.1NP_001374112.1  ataxin-2-like protein isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  20. NM_001387184.1NP_001374113.1  ataxin-2-like protein isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  21. NM_001387185.1NP_001374114.1  ataxin-2-like protein isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209720
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:637917
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  22. NM_001387186.1NP_001374115.1  ataxin-2-like protein isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209720
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:785916
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  23. NM_001387187.1NP_001374116.1  ataxin-2-like protein isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
  24. NM_001387188.1NP_001374117.1  ataxin-2-like protein isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    PHA03247
    Location:6441013
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:209720
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  25. NM_001387189.1NP_001374118.1  ataxin-2-like protein isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  26. NM_001387190.1NP_001374119.1  ataxin-2-like protein isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
  27. NM_001387191.1NP_001374120.1  ataxin-2-like protein isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    PHA03247
    Location:398943
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:8651035
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  28. NM_001387192.1NP_001374121.1  ataxin-2-like protein isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  29. NM_001387193.1NP_001374122.1  ataxin-2-like protein isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  30. NM_001387194.1NP_001374123.1  ataxin-2-like protein isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398943
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  31. NM_001387195.1NP_001374124.1  ataxin-2-like protein isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  32. NM_001387196.1NP_001374125.1  ataxin-2-like protein isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  33. NM_001387197.1NP_001374126.1  ataxin-2-like protein isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    PHA03247
    Location:6501033
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:209726
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  34. NM_001387198.1NP_001374127.1  ataxin-2-like protein isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  35. NM_001387199.1NP_001374128.1  ataxin-2-like protein isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209721
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:638918
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  36. NM_001387200.1NP_001374129.1  ataxin-2-like protein isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209726
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:643923
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  37. NM_001387202.1NP_001374131.1  ataxin-2-like protein isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (4) summary
    COG5180
    Location:209720
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:637917
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  38. NM_001387203.1NP_001374132.1  ataxin-2-like protein isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PRK10263
    Location:598878
    PRK10263; DNA translocase FtsK; Provisional
    PRK14971
    Location:338489
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  39. NM_001387204.1NP_001374133.1  ataxin-2-like protein isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Conserved Domains (3) summary
    PHA03247
    Location:398979
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  40. NM_007245.4NP_009176.2  ataxin-2-like protein isoform 1

    See identical proteins and their annotated locations for NP_009176.2

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS10641.1
    UniProtKB/Swiss-Prot
    Q8WWM7
    Related
    ENSP00000338718.4, ENST00000336783.9
    Conserved Domains (3) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  41. NM_017492.4NP_059867.3  ataxin-2-like protein isoform 6

    See identical proteins and their annotated locations for NP_059867.3

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS58443.1
    UniProtKB/Swiss-Prot
    Q8WWM7
    Related
    ENSP00000454516.1, ENST00000570200.5
    Conserved Domains (3) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  42. NM_145714.3NP_663760.1  ataxin-2-like protein isoform 2

    See identical proteins and their annotated locations for NP_663760.1

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS32423.1
    UniProtKB/Swiss-Prot
    Q8WWM7
    Related
    ENSP00000315650.6, ENST00000325215.10
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:757941
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  43. NM_148414.3NP_680780.1  ataxin-2-like protein isoform 3

    See identical proteins and their annotated locations for NP_680780.1

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS10640.1
    UniProtKB/Swiss-Prot
    Q8WWM7
    Related
    ENSP00000378917.2, ENST00000395547.6
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  44. NM_148415.3NP_680781.1  ataxin-2-like protein isoform 4

    See identical proteins and their annotated locations for NP_680781.1

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS10639.1
    UniProtKB/Swiss-Prot
    Q8WWM7
    Related
    ENSP00000341459.8, ENST00000340394.12
    Conserved Domains (2) summary
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  45. NM_148416.3NP_680782.1  ataxin-2-like protein isoform 5

    See identical proteins and their annotated locations for NP_680782.1

    Status: REVIEWED

    Source sequence(s)
    AC116346, AC133550, AC145285
    Consensus CDS
    CCDS45451.1
    UniProtKB/Swiss-Prot
    Q8WWM7
    Related
    ENSP00000372133.4, ENST00000382686.8
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:757941
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    28822999..28837237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255061.1XP_005255118.1  ataxin-2-like protein isoform X1

    See identical proteins and their annotated locations for XP_005255118.1

    Conserved Domains (5) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:815946
    PRK10263; DNA translocase FtsK; Provisional
    pfam03154
    Location:7401094
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  2. XM_011545719.2XP_011544021.1  ataxin-2-like protein isoform X1

    See identical proteins and their annotated locations for XP_011544021.1

    Conserved Domains (5) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:815946
    PRK10263; DNA translocase FtsK; Provisional
    pfam03154
    Location:7401094
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  3. XM_005255062.1XP_005255119.1  ataxin-2-like protein isoform X1

    See identical proteins and their annotated locations for XP_005255119.1

    Conserved Domains (5) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:815946
    PRK10263; DNA translocase FtsK; Provisional
    pfam03154
    Location:7401094
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  4. XM_006721009.1XP_006721072.1  ataxin-2-like protein isoform X11

    See identical proteins and their annotated locations for XP_006721072.1

    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  5. XM_005255070.1XP_005255127.1  ataxin-2-like protein isoform X9

    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  6. XM_005255067.1XP_005255124.1  ataxin-2-like protein isoform X5

    See identical proteins and their annotated locations for XP_005255124.1

    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  7. XM_005255068.1XP_005255125.1  ataxin-2-like protein isoform X5

    See identical proteins and their annotated locations for XP_005255125.1

    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  8. XM_006721011.1XP_006721074.1  ataxin-2-like protein isoform X15

    See identical proteins and their annotated locations for XP_006721074.1

    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  9. XM_006721012.4XP_006721075.1  ataxin-2-like protein isoform X15

    See identical proteins and their annotated locations for XP_006721075.1

    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  10. XM_005255074.1XP_005255131.1  ataxin-2-like protein isoform X12

    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  11. XM_005255075.1XP_005255132.1  ataxin-2-like protein isoform X13

    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  12. XM_005255064.1XP_005255121.1  ataxin-2-like protein isoform X2

    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:667947
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  13. XM_006721007.1XP_006721070.1  ataxin-2-like protein isoform X7

    Conserved Domains (4) summary
    COG5180
    Location:209726
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:739924
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  14. XM_005255065.1XP_005255122.1  ataxin-2-like protein isoform X3

    Conserved Domains (3) summary
    pfam03153
    Location:8761068
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  15. XM_005255066.1XP_005255123.1  ataxin-2-like protein isoform X4

    See identical proteins and their annotated locations for XP_005255123.1

    UniProtKB/Swiss-Prot
    Q8WWM7
    Conserved Domains (4) summary
    COG5180
    Location:209744
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:661941
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  16. XM_006721008.1XP_006721071.1  ataxin-2-like protein isoform X8

    Conserved Domains (4) summary
    COG5180
    Location:209720
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:733918
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  17. XM_006721010.2XP_006721073.1  ataxin-2-like protein isoform X11

    See identical proteins and their annotated locations for XP_006721073.1

    Conserved Domains (4) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:763948
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:122191
    SM-ATX; Ataxin 2 SM domain
  18. XM_005255063.4XP_005255120.1  ataxin-2-like protein isoform X1

    See identical proteins and their annotated locations for XP_005255120.1

    Conserved Domains (5) summary
    COG5180
    Location:209750
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:815946
    PRK10263; DNA translocase FtsK; Provisional
    pfam03154
    Location:7401094
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:264326
    LsmAD; LsmAD domain
    pfam14438
    Location:123196
    SM-ATX; Ataxin 2 SM domain
  19. XM_005255077.1XP_005255134.1  ataxin-2-like protein isoform X16

    Conserved Domains (4) summary
    COG5180
    Location:149690
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:703888
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:204266
    LsmAD; LsmAD domain
    pfam14438
    Location:62131
    SM-ATX; Ataxin 2 SM domain
  20. XM_017022891.1XP_016878380.1  ataxin-2-like protein isoform X17

  21. XM_011545722.1XP_011544024.1  ataxin-2-like protein isoform X18

    Conserved Domains (4) summary
    COG5180
    Location:87628
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03153
    Location:641826
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06741
    Location:142204
    LsmAD; LsmAD domain
    pfam14438
    Location:169
    SM-ATX; Ataxin 2 SM domain
  22. XM_017022892.1XP_016878381.1  ataxin-2-like protein isoform X19

RNA

  1. XR_001751820.1 RNA Sequence

  2. XR_243256.1 RNA Sequence

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