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KLF8 KLF transcription factor 8 [ Homo sapiens (human) ]

Gene ID: 11279, updated on 5-Mar-2024

Summary

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Official Symbol
KLF8provided by HGNC
Official Full Name
KLF transcription factor 8provided by HGNC
Primary source
HGNC:HGNC:6351
See related
Ensembl:ENSG00000102349 MIM:300286; AllianceGenome:HGNC:6351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BKLF3; ZNF741
Summary
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Expression
Broad expression in skin (RPKM 8.2), fat (RPKM 3.4) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
Xp11.21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55908123..56291531)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (55201315..55584861)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55934556..56317964)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chrX:55700255-55700456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29682 Neighboring gene XAGE-4 protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20868 Neighboring gene Ras related GTP binding B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29684 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:55945424-55946623 Neighboring gene uncharacterized LOC124905192 Neighboring gene uncharacterized LOC124905193 Neighboring gene GOT2 pseudogene 6 Neighboring gene uncharacterized LOC124900486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:56140677-56141176 Neighboring gene ribosomal protein L23a pseudogene 83 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:56589763-56590390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29688 Neighboring gene uncharacterized LOC124905194 Neighboring gene ubiquilin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KLF8 is activated by TGF-β1 via Smad2 and contributes to ovarian cancer progression. Cherukunnath A, et al. J Cell Biochem, 2022 May. PMID 35293014
  2. CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis. Wang B, et al. Int J Clin Oncol, 2022 Apr. PMID 35171359
  3. Krüppel-like factor 8 regulates VEGFA expression and angiogenesis in hepatocellular carcinoma. Cheng S, et al. Sci Rep, 2018 Nov 27. PMID 30479372, Free PMC Article
  4. Krüppel-Like Factor 8 Overexpression Correlates with Poor Prognosis in Non-Small Cell Lung Cancer. Li J, et al. Pathol Oncol Res, 2019 Jan. PMID 28986741
  5. KLF8 knockdown triggered growth inhibition and induced cell phase arrest in human pancreatic cancer cells. Yi X, et al. Gene, 2016 Jul 1. PMID 26995652

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2.
    Title: KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2.
  2. CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis.
    Title: CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis.
  3. KLF8 is activated by TGF-beta1 via Smad2 and contributes to ovarian cancer progression.
    Title: KLF8 is activated by TGF-β1 via Smad2 and contributes to ovarian cancer progression.
  4. Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer.
    Title: Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer.
  5. miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT.
    Title: miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT.
  6. Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/beta-catenin pathway.
    Title: Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/β-catenin pathway.
  7. Upregulated miRNA-1236-3p in osteosarcoma inhibits cell proliferation and induces apoptosis via targeting KLF8.
    Title: Upregulated miRNA-1236-3p in osteosarcoma inhibits cell proliferation and induces apoptosis via targeting KLF8.
  8. KLF8 promotes cancer stem cell-like phenotypes in osteosarcoma through miR-429-SOX2 signaling.
    Title: KLF8 promotes cancer stem cell-like phenotypes in osteosarcoma through miR-429-SOX2 signaling.
  9. KLF8 is associated with poor prognosis and regulates glycolysis by targeting GLUT4 in gastric cancer.
    Title: KLF8 is associated with poor prognosis and regulates glycolysis by targeting GLUT4 in gastric cancer.
  10. KLF8-overexpressing hepatocellular carcinoma cells had a higher potential for inducing angiogenesis. The up-regulation of KLF8 increased VEGFA protein levels and induced VEGFA promoter activity by binding to the CACCC region of the VEGFA promoter.
    Title: Krüppel-like factor 8 regulates VEGFA expression and angiogenesis in hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (47)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-10-12)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-10-12)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC138314, DKFZp686O08126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in aggresome IDA
Inferred from Direct Assay
more info
  
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
Krueppel-like factor 8
Names
Kruppel like factor 8
basic krueppel-like factor 3
basic kruppel-like factor 3
zinc finger protein 741

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011949.2 RefSeqGene

    Range
    329234..388409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001159296.2 → NP_001152768.1  Krueppel-like factor 8 isoform 2

    See identical proteins and their annotated locations for NP_001152768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 3' coding region that causes a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK296156, AL050309, BX322609, DA874419
    Consensus CDS
    CCDS55428.1
    UniProtKB/Swiss-Prot
    O95600
    Related
    ENSP00000364063.3, ENST00000374928.7
    Conserved Domains (1) summary
    cl40450
    Location:48 → 216
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  2. NM_001324099.1 → NP_001311028.1  Krueppel-like factor 8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    BC105130, BX322609, HF546208
    Consensus CDS
    CCDS87749.1
    UniProtKB/Swiss-Prot
    O95600
    Related
    ENSP00000492126.1, ENST00000640927.1
    Conserved Domains (1) summary
    cl40450
    Location:43 → 211
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  3. NM_001324100.1 → NP_001311029.1  Krueppel-like factor 8 isoform 4

    Status: REVIEWED

    Source sequence(s)
    BC105130, BX322609, HF546209
    UniProtKB/Swiss-Prot
    O95600
    Conserved Domains (4) summary
    COG5048
    Location:218 → 271
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:222 → 244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220 → 244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:236 → 261
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001324102.1 → NP_001311031.1  Krueppel-like factor 8 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL050309, BX322609
    Consensus CDS
    CCDS14373.1
    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4
    Conserved Domains (4) summary
    COG5048
    Location:220 → 346
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:276 → 298
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:320 → 345
    zf-H2C2_2; Zinc-finger double domain
    cd21440
    Location:48 → 216
    KLF8_N; N-terminal domain of Kruppel-like factor 8

  5. NM_001324104.1 → NP_001311033.1  Krueppel-like factor 8 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) initiates at an upstream promoter compared to variant 1.
    Source sequence(s)
    AL050309, AL353698, AL445472, BX322609

  6. NM_001324105.1 → NP_001311034.1  Krueppel-like factor 8 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) initiates at an upstream promoter compared to variant 1.
    Source sequence(s)
    AL050309, AL445472, BX322609
    Conserved Domains (4) summary
    COG5048
    Location:269 → 339
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273 → 295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:317 → 342
    zf-H2C2_2; Zinc-finger double domain
    cd21440
    Location:45 → 213
    KLF8_N; N-terminal domain of Kruppel-like factor 8

  7. NM_007250.5 → NP_009181.2  Krueppel-like factor 8 isoform 1

    See identical proteins and their annotated locations for NP_009181.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AL050309, BC105130, BX322609
    Consensus CDS
    CCDS14373.1
    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4
    Related
    ENSP00000417303.1, ENST00000468660.6
    Conserved Domains (4) summary
    COG5048
    Location:220 → 346
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:276 → 298
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:320 → 345
    zf-H2C2_2; Zinc-finger double domain
    cd21440
    Location:48 → 216
    KLF8_N; N-terminal domain of Kruppel-like factor 8

RNA

  1. NR_136704.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BC031355, BC105130, BX322609

  2. NR_136705.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB209004, AL050309, BX322609

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    55908123..56291531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441797.1 → XP_047297753.1  Krueppel-like factor 8 isoform X1

    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

  2. XM_047441798.1 → XP_047297754.1  Krueppel-like factor 8 isoform X1

    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

  3. XM_006724575.3 → XP_006724638.1  Krueppel-like factor 8 isoform X3

    See identical proteins and their annotated locations for XP_006724638.1

    UniProtKB/Swiss-Prot
    O95600
    Conserved Domains (1) summary
    cl40450
    Location:48 → 216
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  4. XM_017029250.3 → XP_016884739.1  Krueppel-like factor 8 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:267 → 337
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:269 → 293
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:315 → 340
    zf-H2C2_2; Zinc-finger double domain

  5. XM_047441795.1 → XP_047297751.1  Krueppel-like factor 8 isoform X1

    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

  6. XM_047441799.1 → XP_047297755.1  Krueppel-like factor 8 isoform X1

    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

  7. XM_047441796.1 → XP_047297752.1  Krueppel-like factor 8 isoform X1

    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

  8. XM_047441800.1 → XP_047297756.1  Krueppel-like factor 8 isoform X2

  9. XM_024452332.2 → XP_024308100.1  Krueppel-like factor 8 isoform X4

    UniProtKB/TrEMBL
    Q05BZ3
    Related
    ENSP00000431911.1, ENST00000358094.7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    55201315..55584861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326416.1 → XP_054182391.1  Krueppel-like factor 8 isoform X2

  2. XM_054326412.1 → XP_054182387.1  Krueppel-like factor 8 isoform X1

    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

  3. XM_054326413.1 → XP_054182388.1  Krueppel-like factor 8 isoform X1

    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

  4. XM_054326417.1 → XP_054182392.1  Krueppel-like factor 8 isoform X2

  5. XM_054326418.1 → XP_054182393.1  Krueppel-like factor 8 isoform X2

  6. XM_054326410.1 → XP_054182385.1  Krueppel-like factor 8 isoform X1

    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

  7. XM_054326414.1 → XP_054182389.1  Krueppel-like factor 8 isoform X1

    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

  8. XM_054326411.1 → XP_054182386.1  Krueppel-like factor 8 isoform X1

    UniProtKB/Swiss-Prot
    B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

  9. XM_054326419.1 → XP_054182394.1  Krueppel-like factor 8 isoform X3

  10. XM_054326415.1 → XP_054182390.1  Krueppel-like factor 8 isoform X2

  11. XM_054326420.1 → XP_054182395.1  Krueppel-like factor 8 isoform X4

    UniProtKB/TrEMBL
    Q05BZ3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95600.2 GenPept UniProtKB/Swiss-Prot:O95600

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