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Abi1 abl interactor 1 [ Mus musculus (house mouse) ]

Gene ID: 11308, updated on 16-Oct-2021

Summary

Official Symbol
Abi1provided by MGI
Official Full Name
abl interactor 1provided by MGI
Primary source
MGI:MGI:104913
See related
Ensembl:ENSMUSG00000058835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E3B1; NAP1; abi-1; Ssh3bp1
Expression
Ubiquitous expression in bladder adult (RPKM 20.0), cortex adult (RPKM 19.0) and 28 other tissues See more
Orthologs
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Genomic context

See Abi1 in Genome Data Viewer
Location:
2 A3; 2 15.18 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (22830085..22930275, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (22940073..23040241, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (22795509..22895760, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein Neighboring gene predicted gene, 52503 Neighboring gene prenyl (solanesyl) diphosphate synthase, subunit 1 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 52502 Neighboring gene acyl-Coenzyme A binding domain containing 5 Neighboring gene microtubule associated serine/threonine kinase-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6064

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of SCAR complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SCAR complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium tip ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular anatomical structure ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
abl interactor 1
Names
abelson interactor 1
ablphilin-1
eps8 SH3 domain-binding protein
eps8 binding protein
spectrin SH3 domain binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077190.3NP_001070658.1  abl interactor 1 isoform 1

    See identical proteins and their annotated locations for NP_001070658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AK034476, AK164040, BP767858, BY278454
    Consensus CDS
    CCDS38061.1
    UniProtKB/Swiss-Prot
    Q8CBW3
    UniProtKB/TrEMBL
    Q3TPY5
    Related
    ENSMUSP00000118491.2, ENSMUST00000123948.8
    Conserved Domains (2) summary
    cd11971
    Location:423481
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
  2. NM_001077192.3NP_001070660.1  abl interactor 1 isoform 4

    See identical proteins and their annotated locations for NP_001070660.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 4) is shorter compared to isoform 1.
    Source sequence(s)
    AK164040, AY033645, BP767858, BY278454
    Consensus CDS
    CCDS38060.1
    UniProtKB/Swiss-Prot
    Q8CBW3
    UniProtKB/TrEMBL
    Q3TPY5
    Related
    ENSMUSP00000120621.2, ENSMUST00000149719.8
    Conserved Domains (2) summary
    pfam07815
    Location:93164
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:388446
    SH3; Src Homology 3 domain superfamily
  3. NM_001077193.3NP_001070661.1  abl interactor 1 isoform 5

    See identical proteins and their annotated locations for NP_001070661.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
    Source sequence(s)
    AK152061, AK164040, BP767858, BY278454
    Consensus CDS
    CCDS38058.1
    UniProtKB/Swiss-Prot
    Q8CBW3
    UniProtKB/TrEMBL
    Q3TPY5
    Related
    ENSMUSP00000110191.4, ENSMUST00000114544.10
    Conserved Domains (2) summary
    pfam07815
    Location:93154
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:330388
    SH3; Src Homology 3 domain superfamily
  4. NM_001331043.1NP_001317972.1  abl interactor 1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting protein (isoform 6) is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK164040, BP767858, BY278454, CJ135811, EL607233
    Consensus CDS
    CCDS84480.1
    UniProtKB/TrEMBL
    B7ZCU0, Q3TPY5
    Related
    ENSMUSP00000088957.7, ENSMUST00000091394.13
  5. NM_001331044.1NP_001317973.1  abl interactor 1 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting protein (isoform 7) is shorter compared to isoform 1.
    Source sequence(s)
    AK152046, AK164040, BP767858, BY278454, CJ135811
    Consensus CDS
    CCDS84481.1
    UniProtKB/TrEMBL
    B7ZCU3, Q3TPY5
    Related
    ENSMUSP00000077997.8, ENSMUST00000078977.14
  6. NM_001331045.1NP_001317974.1  abl interactor 1 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting protein (isoform 8) is shorter compared to isoform 1.
    Source sequence(s)
    AK152046, AK164040, BP767858, BY278454, CJ135811, CX212013
    Consensus CDS
    CCDS84479.1
    UniProtKB/TrEMBL
    B7ZCU4, Q3TPY5
    Related
    ENSMUSP00000090860.7, ENSMUST00000093171.13
  7. NM_001377510.1NP_001364439.1  abl interactor 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Conserved Domains (2) summary
    pfam07815
    Location:93154
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:389447
    SH3; Src Homology 3 domain superfamily
  8. NM_001377511.1NP_001364440.1  abl interactor 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Conserved Domains (1) summary
    cl17036
    Location:209267
    SH3; Src Homology 3 domain superfamily
  9. NM_001377512.1NP_001364441.1  abl interactor 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Conserved Domains (2) summary
    pfam07815
    Location:127
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:206264
    SH3; Src Homology 3 domain superfamily
  10. NM_001377513.1NP_001364442.1  abl interactor 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Conserved Domains (1) summary
    cl17036
    Location:162220
    SH3; Src Homology 3 domain superfamily
  11. NM_007380.4NP_031406.2  abl interactor 1 isoform 3

    See identical proteins and their annotated locations for NP_031406.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
    Source sequence(s)
    AK164040, AK167328, BP767858, BY278454
    Consensus CDS
    CCDS50513.1
    UniProtKB/Swiss-Prot
    Q8CBW3
    UniProtKB/TrEMBL
    Q3TJR5, Q3TPY5
    Related
    ENSMUSP00000120462.2, ENSMUST00000140164.8
    Conserved Domains (2) summary
    cd11971
    Location:417475
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93164
    Abi_HHR; Abl-interactor HHR
  12. NM_145994.3NP_666106.1  abl interactor 1 isoform 2

    See identical proteins and their annotated locations for NP_666106.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AK164040, AK167568, BP767858, BY278454
    Consensus CDS
    CCDS38059.1
    UniProtKB/TrEMBL
    Q3TJ64, Q3TPY5
    Related
    ENSMUSP00000117335.2, ENSMUST00000126112.8
    Conserved Domains (2) summary
    cd11971
    Location:418476
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93164
    Abi_HHR; Abl-interactor HHR

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    22830085..22930275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497619.3XP_006497682.1  abl interactor 1 isoform X1

    See identical proteins and their annotated locations for XP_006497682.1

    UniProtKB/TrEMBL
    B7ZCU2
    Related
    ENSMUSP00000120769.2, ENSMUST00000153931.8
    Conserved Domains (2) summary
    pfam07815
    Location:93156
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:335393
    SH3; Src Homology 3 domain superfamily
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