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MIR9718 microRNA 9718 [ Homo sapiens (human) ]

Gene ID: 113218481, updated on 10-Oct-2023

Summary

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Official Symbol
MIR9718provided by HGNC
Official Full Name
microRNA 9718provided by HGNC
Primary source
HGNC:HGNC:53988
See related
miRBase:MI0030983; AllianceGenome:HGNC:53988
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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Location:
14q23.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (60648648..60648711)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (54855105..54855168)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (61115366..61115429)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15a pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:61110622-61111184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:61113614-61114236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:61114237-61114858 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:61114859-61115480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:61115481-61116101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:61119031-61119800 Neighboring gene VISTA enhancer hs1602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5814 Neighboring gene senescence associated long non-coding RNA 1 Neighboring gene SIX homeobox 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8481 Neighboring gene SIX homeobox 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8483 Neighboring gene MNAT1 component of CDK activating kinase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:61246210-61246710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:61246711-61247211 Neighboring gene mitotic arrest deficient 2 like 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel microRNA regulates osteoclast differentiation via targeting protein inhibitor of activated STAT3 (PIAS3). Liu T, et al. Bone, 2014 Oct. PMID 25019593
  2. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • hsa-mir-9718

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_162089.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL049874

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    60648648..60648711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    54855105..54855168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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