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Acaa1a acetyl-Coenzyme A acyltransferase 1A [ Mus musculus (house mouse) ]

Gene ID: 113868, updated on 25-Jan-2022

Summary

Official Symbol
Acaa1aprovided by MGI
Official Full Name
acetyl-Coenzyme A acyltransferase 1Aprovided by MGI
Primary source
MGI:MGI:2148491
See related
Ensembl:ENSMUSG00000036138 AllianceGenome:MGI:2148491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTL; Acaa; Acaa1; D9Ertd25e
Summary
Predicted to enable C-acyltransferase activity; acetate CoA-transferase activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in monocarboxylic acid metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Located in peroxisome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in duodenum adult (RPKM 294.0), liver adult (RPKM 221.7) and 26 other tissues See more
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Genomic context

See Acaa1a in Genome Data Viewer
Location:
9 F3; 9 71.33 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119170094..119179361)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119341028..119350296)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (119250412..119259413)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene oxidative-stress responsive 1 Neighboring gene myeloid differentiation primary response gene 88 Neighboring gene xylulokinase homolog (H. influenzae) Neighboring gene predicted gene, 53515

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7090

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetate CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acetyl-CoA C-acetyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
enables acetyl-CoA C-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetyl-CoA C-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acetyl-CoA C-myristoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyl-CoA oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phenylacetate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
3-ketoacyl-CoA thiolase A, peroxisomal
Names
acetyl-CoA C-myristoyltransferase
acetyl-CoA acyltransferase A
beta-ketothiolase A
peroxisomal 3-ketoacyl-CoA thiolase
peroxisomal 3-oxoacyl-CoA thiolase A
peroxisomal 3-oxoacyl-Coenzyme A thiolase
thiolase A
NP_001344445.1
NP_570934.1
XP_006511986.1
XP_030099878.1
XP_030099879.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357516.1NP_001344445.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC128702
    Conserved Domains (1) summary
    cl27751
    Location:1268
    Thiolase_N; Thiolase, N-terminal domain
  2. NM_130864.3NP_570934.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform 1 precursor

    See identical proteins and their annotated locations for NP_570934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC128702
    Consensus CDS
    CCDS23613.1
    UniProtKB/Swiss-Prot
    Q921H8
    Related
    ENSMUSP00000042351.6, ENSMUST00000039784.12
    Conserved Domains (1) summary
    PLN02287
    Location:1420
    PLN02287; 3-ketoacyl-CoA thiolase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119170094..119179361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511923.3XP_006511986.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform X1

    See identical proteins and their annotated locations for XP_006511986.1

    UniProtKB/Swiss-Prot
    Q921H8
    Conserved Domains (1) summary
    PLN02287
    Location:1420
    PLN02287; 3-ketoacyl-CoA thiolase
  2. XM_030244019.2XP_030099879.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform X1

    Conserved Domains (1) summary
    PLN02287
    Location:1420
    PLN02287; 3-ketoacyl-CoA thiolase
  3. XM_030244018.2XP_030099878.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform X1

    Conserved Domains (1) summary
    PLN02287
    Location:1420
    PLN02287; 3-ketoacyl-CoA thiolase
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