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Gpnmb glycoprotein nmb [ Rattus norvegicus (Norway rat) ]

Gene ID: 113955, updated on 6-May-2021

Summary

Official Symbol
Gpnmbprovided by RGD
Official Full Name
glycoprotein nmbprovided by RGD
Primary source
RGD:71008
See related
Ensembl:ENSRNOG00000008816
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may play a role in bone matrix production and mineralization; overexpressed in the osteopetrosis mutant op rat [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 680.2), Lung (RPKM 437.6) and 8 other tissues See more
Orthologs
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Genomic context

See Gpnmb in Genome Data Viewer
Location:
4q24
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (78010247..78031491)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78694447..78715685)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene seminal vesicle secretory protein 1 Neighboring gene uncharacterized LOC102546557 Neighboring gene mitochondrial assembly of ribosomal large subunit 1 Neighboring gene insulin-like growth factor 2 mRNA binding protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables syndecan binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bone mineralization IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of tissue remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane glycoprotein NMB
Names
glycoprotein (transmembrane) nmb
osteoactivin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133298.1NP_579832.1  transmembrane glycoprotein NMB precursor

    See identical proteins and their annotated locations for NP_579832.1

    Status: PROVISIONAL

    Source sequence(s)
    AF184983
    UniProtKB/TrEMBL
    Q9QZF6
    Related
    ENSRNOP00000011945.3, ENSRNOT00000011945.4
    Conserved Domains (1) summary
    cd00146
    Location:263316
    PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    78010247..78031491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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