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Cxcl2 C-X-C motif chemokine ligand 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114105, updated on 6-May-2021

Summary

Official Symbol
Cxcl2provided by RGD
Official Full Name
C-X-C motif chemokine ligand 2provided by RGD
Primary source
RGD:70069
See related
Ensembl:ENSRNOG00000002792
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mip-2; Scyb2
Summary
chemokine involved in the pulmonary inflammatory response [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 7.6), Thymus (RPKM 2.7) and 6 other tissues See more
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Genomic context

See Cxcl2 in Genome Data Viewer
Location:
14p22
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (17181030..17183075, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (18731346..18733391, complement)

Chromosome 14 - NC_051349.1Genomic Context describing neighboring genes Neighboring gene epithelial mitogen Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Neighboring gene C-X-C motif chemokine ligand 1 Neighboring gene similar to Alpha-enolase (2-phospho-D-glycerate hydro-lyase) (Non-neural enolase) (NNE) (Enolase 1)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CXCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in killing of cells of other organism ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to amphetamine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to gamma radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to molecule of bacterial origin ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-X-C motif chemokine 2
Names
CINC-3
MIP2
chemokine (C-X-C motif) ligand 2
cytokine-induced neutrophil chemoattractant 3
macrophage inflammatory protein 2
small inducible cytokine subfamily, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053647.2NP_446099.1  C-X-C motif chemokine 2 precursor

    See identical proteins and their annotated locations for NP_446099.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000250
    UniProtKB/Swiss-Prot
    P30348
    Related
    ENSRNOP00000003745.3, ENSRNOT00000003745.6
    Conserved Domains (1) summary
    cd00273
    Location:3395
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051349.1 Reference mRatBN7.2 Primary Assembly

    Range
    17181030..17183075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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