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Aipl1 aryl hydrocarbon receptor-interacting protein-like 1 [ Mus musculus (house mouse) ]

Gene ID: 114230, updated on 21-Apr-2024

Summary

Official Symbol
Aipl1provided by MGI
Official Full Name
aryl hydrocarbon receptor-interacting protein-like 1provided by MGI
Primary source
MGI:MGI:2148800
See related
Ensembl:ENSMUSG00000040554 AllianceGenome:MGI:2148800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930007I01Rik
Summary
Predicted to enable farnesylated protein binding activity. Acts upstream of or within several processes, including phototransduction, visible light; regulation of rhodopsin mediated signaling pathway; and retina homeostasis. Located in photoreceptor inner segment. Used to study Leber congenital amaurosis 4. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 4; blindness; and retinitis pigmentosa. Orthologous to human AIPL1 (aryl hydrocarbon receptor interacting protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

Location:
11 B4; 11 43.81 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (71919527..71933184, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72028717..72042460, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:71809517-71809670 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:71809714-71809823 Neighboring gene predicted gene, 23226 Neighboring gene STARR-positive B cell enhancer ABC_E9825 Neighboring gene STARR-positive B cell enhancer ABC_E8421 Neighboring gene PICALM interacting mitotic regulator Neighboring gene PITPNM family member 3 Neighboring gene predicted gene, 46286 Neighboring gene STARR-seq mESC enhancer starr_29899 Neighboring gene RIKEN cDNA 4933427D14 gene Neighboring gene predicted gene, 57849

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Clone Names

  • MGC25485

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables farnesylated protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aryl-hydrocarbon-interacting protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053245.2NP_444475.2  aryl-hydrocarbon-interacting protein-like 1

    See identical proteins and their annotated locations for NP_444475.2

    Status: VALIDATED

    Source sequence(s)
    AF296412, AK020825, BF464935, CK618559
    Consensus CDS
    CCDS24976.1
    UniProtKB/Swiss-Prot
    Q5RI54, Q924K1
    Related
    ENSMUSP00000036279.4, ENSMUST00000048207.10
    Conserved Domains (4) summary
    PLN03088
    Location:261304
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    COG0457
    Location:179321
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:180224
    TPR; TPR repeat [structural motif]
    cl19519
    Location:3089
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    71919527..71933184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245477.2XP_030101337.1  aryl-hydrocarbon-interacting protein-like 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5RI54, Q924K1
    Conserved Domains (4) summary
    PLN03088
    Location:261304
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    COG0457
    Location:179321
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:180224
    TPR; TPR repeat [structural motif]
    cl19519
    Location:3089
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  2. XM_030245476.2XP_030101336.1  aryl-hydrocarbon-interacting protein-like 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5RI54, Q924K1
    Conserved Domains (4) summary
    PLN03088
    Location:261304
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    COG0457
    Location:179321
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:180224
    TPR; TPR repeat [structural motif]
    cl19519
    Location:3089
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  3. XM_006531999.5XP_006532062.1  aryl-hydrocarbon-interacting protein-like 1 isoform X2

    Conserved Domains (3) summary
    COG0457
    Location:176324
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:185227
    TPR; TPR repeat [structural motif]
    cl19519
    Location:3594
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  4. XM_006531997.5XP_006532060.1  aryl-hydrocarbon-interacting protein-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006532060.1

    Conserved Domains (4) summary
    PLN03088
    Location:266309
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    COG0457
    Location:184326
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:185229
    TPR; TPR repeat [structural motif]
    cl19519
    Location:3594
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase