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Aco2 aconitase 2, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 11429, updated on 2-Aug-2021

Summary

Official Symbol
Aco2provided by MGI
Official Full Name
aconitase 2, mitochondrialprovided by MGI
Primary source
MGI:MGI:87880
See related
Ensembl:ENSMUSG00000022477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ac; Aco; Aco3; Aco-2; D10Wsu183; D10Wsu183e
Expression
Ubiquitous expression in heart adult (RPKM 787.3), kidney adult (RPKM 344.6) and 28 other tissues See more
Orthologs
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Genomic context

See Aco2 in Genome Data Viewer
Location:
15; 15 E1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81756664..81799338)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81872463..81915137)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (81702893..81745567)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transducer of ERBB2, 2 Neighboring gene PHD finger protein 5A Neighboring gene polymerase (RNA) III (DNA directed) polypeptide H Neighboring gene cold shock domain containing C2, RNA binding Neighboring gene phosphomannomutase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 
enables aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aconitate hydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aconitate hydratase activity ISO
Inferred from Sequence Orthology
more info
 
enables citrate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within citrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in citrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in isocitrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
aconitate hydratase, mitochondrial
Names
citrate hydro-lyase
NP_542364.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080633.2NP_542364.1  aconitate hydratase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_542364.1

    Status: VALIDATED

    Source sequence(s)
    BI987806, BQ031215, BY732916, CA750686, CO426953, CO429053
    Consensus CDS
    CCDS27675.1
    UniProtKB/Swiss-Prot
    Q99KI0
    Related
    ENSMUSP00000023116.7, ENSMUST00000023116.7
    Conserved Domains (3) summary
    cd01584
    Location:95505
    AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
    cd01578
    Location:587735
    AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
    TIGR01340
    Location:45775
    aconitase_mito; aconitate hydratase, mitochondrial

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    81756664..81799338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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