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Rgs14 regulator of G-protein signaling 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114705, updated on 8-Jul-2021

Summary

Official Symbol
Rgs14provided by RGD
Official Full Name
regulator of G-protein signaling 14provided by RGD
Primary source
RGD:620003
See related
Ensembl:ENSRNOG00000015616
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
binds Galpha(i1)GDP and acts as a GTPase activator by maintaining G-protein subunit dissociation; regulates G-protein mediated signaling [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 184.2), Spleen (RPKM 69.0) and 3 other tissues See more
Orthologs
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Genomic context

See Rgs14 in Genome Data Viewer
Location:
17p14
Exon count:
16
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9248982..9263104, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9777925..9792007, complement)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 member 1 Neighboring gene U6 spliceosomal RNA Neighboring gene lectin, mannose-binding 2 Neighboring gene Max dimerization protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC108631

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor complex adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in learning ISO
Inferred from Sequence Orthology
more info
 
involved_in learning ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription in response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zygote asymmetric cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in zygote asymmetric cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
regulator of G-protein signaling 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053764.2NP_446216.1  regulator of G-protein signaling 14

    See identical proteins and their annotated locations for NP_446216.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000284
    UniProtKB/Swiss-Prot
    O08773
    Related
    ENSRNOP00000021596.1, ENSRNOT00000021596.2
    Conserved Domains (4) summary
    cd01817
    Location:301374
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08743
    Location:58186
    RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
    smart00390
    Location:497519
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cl00155
    Location:382443
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    9248982..9263104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095287.1XP_038951215.1  regulator of G-protein signaling 14 isoform X1

    Conserved Domains (4) summary
    smart00390
    Location:344366
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17137
    Location:147217
    RBD1_RGS14; Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14)
    cd17139
    Location:218289
    RBD2_RGS14; Ras-binding domain (RBD) 2 of regulator of G protein signaling 14 (RGS14)
    cl02565
    Location:133
    RGS; Regulator of G protein signaling (RGS) domain superfamily
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