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TUBGCP5 tubulin gamma complex component 5 [ Homo sapiens (human) ]

Gene ID: 114791, updated on 3-Apr-2024

Summary

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Official Symbol
TUBGCP5provided by HGNC
Official Full Name
tubulin gamma complex component 5provided by HGNC
Primary source
HGNC:HGNC:18600
See related
Ensembl:ENSG00000275835 MIM:608147; AllianceGenome:HGNC:18600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCP5
Summary
Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 5.8), brain (RPKM 3.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
15q11.2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (22983025..23039569, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (20654893..20711463, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (22833499..22890043)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr15:23086519-23086752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:23080143-23080643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9155 Neighboring gene NIPA magnesium transporter 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:23045427-23046179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9158 Neighboring gene NIPA magnesium transporter 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22999149-22999824 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:22990202-22991401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22981163-22981662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22980661-22981162 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22925256-22925940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22905531-22906030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22896003-22896502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22895501-22896002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22893404-22894371 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22892435-22893403 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22859095-22860005 Neighboring gene NANOG hESC enhancer GRCh37_chr15:22803142-22803643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22798435-22798945 Neighboring gene engulfment and cell motility 2 pseudogene 1 Neighboring gene WAS/WASL-interacting protein family member 3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5. Izumi N, et al. J Biol Chem, 2008 May 9. PMID 18316369
  2. Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome. Bittel DC, et al. Pediatrics, 2006 Oct. PMID 16982806, Free PMC Article
  3. GCP5 and GCP6: two new members of the human gamma-tubulin complex. Murphy SM, et al. Mol Biol Cell, 2001 Nov. PMID 11694571, Free PMC Article
  4. Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis. Hsu HL, et al. J Cell Sci, 1996 Feb. PMID 8838651
  5. CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. Choi YK, et al. J Cell Biol, 2010 Dec 13. PMID 21135143, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GSK-3beta regulates the localization of gamma-tubulin ring complex, including GCP5, to the spindle poles, thereby controlling the formation of proper mitotic spindles
    Title: GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5.
  2. located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes
    Title: Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.
  3. quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5 in Prader-Willi syndrome and correlated levels with psychological and behavior scales
    Title: Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1899

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin ring complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-tubulin complex component 5
Names
gamma-tubulin complex component GCP5
tubulin gamma complex associated protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102610.2 → NP_001096080.1  gamma-tubulin complex component 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at its 3' terminal exon, compared to variant 1, and encodes isoform b. Isoforms a and b are identical in length but differ in their C-termini.
    Source sequence(s)
    AB067486, AC116166, AK056416
    Consensus CDS
    CCDS73697.1
    UniProtKB/TrEMBL
    A0A0G2JQX1
    Related
    ENSP00000481853.1, ENST00000620435.4
    Conserved Domains (1) summary
    pfam04130
    Location:273 → 942
    Spc97_Spc98; Spc97 / Spc98 family

  2. NM_001354372.2 → NP_001341301.1  gamma-tubulin complex component 5 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    UniProtKB/TrEMBL
    A0A0G2JPW5, A0A0G2JQX1, A8K1E4
    Conserved Domains (1) summary
    pfam04130
    Location:274 → 943
    Spc97_Spc98; Spc97 / Spc98 family

  3. NM_001354373.2 → NP_001341302.1  gamma-tubulin complex component 5 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    UniProtKB/TrEMBL
    A0A0G2JPW5, A0A0G2JQX1, A8K1E4
    Related
    ENSP00000484566.1, ENST00000614508.4
    Conserved Domains (1) summary
    pfam04130
    Location:273 → 942
    Spc97_Spc98; Spc97 / Spc98 family

  4. NM_001354374.2 → NP_001341303.1  gamma-tubulin complex component 5 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    UniProtKB/TrEMBL
    A0A0G2JPW5, A0A0G2JQX1, A8K1E4
    Conserved Domains (1) summary
    pfam04130
    Location:273 → 928
    Spc97_Spc98; Spc97 / Spc98 family

  5. NM_001354375.2 → NP_001341304.1  gamma-tubulin complex component 5 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    UniProtKB/TrEMBL
    A0A087X1Z1
    Conserved Domains (1) summary
    pfam04130
    Location:273 → 942
    Spc97_Spc98; Spc97 / Spc98 family

  6. NM_001354376.2 → NP_001341305.1  gamma-tubulin complex component 5 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    UniProtKB/TrEMBL
    A0A087X1Z1
    Conserved Domains (1) summary
    pfam04130
    Location:273 → 942
    Spc97_Spc98; Spc97 / Spc98 family

  7. NM_001354377.2 → NP_001341306.1  gamma-tubulin complex component 5 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice sites compared to variant 1, and encodes isoform h. Isoforms h and i are identical in length but differ in their C-termini.
    Source sequence(s)
    AC116166
    UniProtKB/TrEMBL
    A0A0G2JPW5, A8K1E4
    Conserved Domains (1) summary
    pfam04130
    Location:274 → 943
    Spc97_Spc98; Spc97 / Spc98 family

  8. NM_001354378.2 → NP_001341307.1  gamma-tubulin complex component 5 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice sites compared to variant 1, and encodes isoform i. Isoforms h and i are identical in length but differ in their C-termini.
    Source sequence(s)
    AC116166
    UniProtKB/TrEMBL
    A0A0G2JQX1
    Conserved Domains (1) summary
    pfam04130
    Location:274 → 943
    Spc97_Spc98; Spc97 / Spc98 family

  9. NM_052903.6 → NP_443135.3  gamma-tubulin complex component 5 isoform a

    See identical proteins and their annotated locations for NP_443135.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Isoforms a and b are identical in length but differ in their C-termini.
    Source sequence(s)
    AB067486, BC071560
    Consensus CDS
    CCDS73698.1
    UniProtKB/Swiss-Prot
    E9PB12, Q6IQ52, Q96PY8, Q96RT8
    UniProtKB/TrEMBL
    A0A0G2JPW5, A8K1E4
    Related
    ENSP00000480316.1, ENST00000615383.5
    Conserved Domains (2) summary
    pfam04130
    Location:716 → 1017
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:271 → 577
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RNA

  1. NR_148875.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    22983025..23039569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432130.1 → XP_047288086.1  gamma-tubulin complex component 5 isoform X3

  2. XM_017021895.2 → XP_016877384.1  gamma-tubulin complex component 5 isoform X4

    UniProtKB/TrEMBL
    A8K1E4

  3. XM_017021894.2 → XP_016877383.1  gamma-tubulin complex component 5 isoform X3

    UniProtKB/TrEMBL
    A8K1E4

  4. XM_017021896.2 → XP_016877385.1  gamma-tubulin complex component 5 isoform X6

  5. XM_017021901.2 → XP_016877390.1  gamma-tubulin complex component 5 isoform X7

  6. XM_011543870.3 → XP_011542172.1  gamma-tubulin complex component 5 isoform X2

    UniProtKB/TrEMBL
    A0A087X1Z1
    Conserved Domains (1) summary
    pfam04130
    Location:274 → 943
    Spc97_Spc98; Spc97 / Spc98 family

  7. XM_011543868.3 → XP_011542170.1  gamma-tubulin complex component 5 isoform X1

    UniProtKB/TrEMBL
    A0A087X1Z1
    Conserved Domains (1) summary
    pfam04130
    Location:274 → 943
    Spc97_Spc98; Spc97 / Spc98 family

  8. XM_047432131.1 → XP_047288087.1  gamma-tubulin complex component 5 isoform X5

RNA

  1. XR_007064420.1 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160017.1 Reference GRCh38.p14 PATCHES

    Range
    3877112..3933660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332577.1 → XP_054188552.1  gamma-tubulin complex component 5 isoform X3

  2. XM_054332579.1 → XP_054188554.1  gamma-tubulin complex component 5 isoform X4

  3. XM_054332578.1 → XP_054188553.1  gamma-tubulin complex component 5 isoform X3

  4. XM_054332581.1 → XP_054188556.1  gamma-tubulin complex component 5 isoform X6

  5. XM_054332582.1 → XP_054188557.1  gamma-tubulin complex component 5 isoform X7

  6. XM_054332576.1 → XP_054188551.1  gamma-tubulin complex component 5 isoform X2

  7. XM_054332575.1 → XP_054188550.1  gamma-tubulin complex component 5 isoform X1

  8. XM_054332580.1 → XP_054188555.1  gamma-tubulin complex component 5 isoform X5

RNA

  1. XR_008485783.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187603.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    79960..136590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329039.1 → XP_054185014.1  gamma-tubulin complex component 5 isoform X7

  2. XM_054329038.1 → XP_054185013.1  gamma-tubulin complex component 5 isoform X6

  3. XM_054329037.1 → XP_054185012.1  gamma-tubulin complex component 5 isoform X3

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187659.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    1543..4302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    20654893..20711463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377247.1 → XP_054233222.1  gamma-tubulin complex component 5 isoform X3

  2. XM_054377249.1 → XP_054233224.1  gamma-tubulin complex component 5 isoform X4

  3. XM_054377248.1 → XP_054233223.1  gamma-tubulin complex component 5 isoform X3

  4. XM_054377251.1 → XP_054233226.1  gamma-tubulin complex component 5 isoform X6

  5. XM_054377252.1 → XP_054233227.1  gamma-tubulin complex component 5 isoform X7

  6. XM_054377246.1 → XP_054233221.1  gamma-tubulin complex component 5 isoform X2

  7. XM_054377245.1 → XP_054233220.1  gamma-tubulin complex component 5 isoform X1

  8. XM_054377250.1 → XP_054233225.1  gamma-tubulin complex component 5 isoform X5

RNA

  1. XR_008488915.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96RT8.1 GenPept UniProtKB/Swiss-Prot:Q96RT8

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