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Dusp1 dual specificity phosphatase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114856, updated on 28-Nov-2021

Summary

Official Symbol
Dusp1provided by RGD
Official Full Name
dual specificity phosphatase 1provided by RGD
Primary source
RGD:620897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mkp1; CL100; MKP-1; 3CH134; Ptpn16
Summary
This gene encodes a protein that catalyzes the dephosphorylation and inactivation of MAP kinase, and may be involved in insulin mediated signalling. [provided by RefSeq, Jul 2008]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Lung (RPKM 351.5), Muscle (RPKM 296.5) and 9 other tissues See more
Orthologs
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Genomic context

See Dusp1 in Genome Data Viewer
Location:
10q12
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (16680489..16683276)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (16970642..16973425)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum-golgi intermediate compartment 1 Neighboring gene uncharacterized LOC102552476 Neighboring gene neuralized E3 ubiquitin protein ligase 1B Neighboring gene uncharacterized LOC102555877

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase tyrosine/serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables MAP kinase tyrosine/serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
enables growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in endoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-threonine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to light stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 1
Names
3CH134/CL100 PTPase
MAP kinase phosphatase-1
mitogen-activated protein (MAP) kinase phosphatase-1
mitogen-activated protein kinase phosphatase 1
oxidative stress-inducible protein tyrosine phosphatase
protein-tyrosine phosphatase CL100
protein-tyrosine phosphatase non-receptor type 16
NP_446221.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053769.4NP_446221.2  dual specificity protein phosphatase 1

    See identical proteins and their annotated locations for NP_446221.2

    Status: VALIDATED

    Source sequence(s)
    BI297083, FM064786, JACYVU010000219, U02553
    UniProtKB/Swiss-Prot
    Q64623
    UniProtKB/TrEMBL
    Q63683
    Conserved Domains (3) summary
    COG2453
    Location:188313
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:173309
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:7136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    16680489..16683276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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