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Dscaml1 DS cell adhesion molecule like 1 [ Mus musculus (house mouse) ]

Gene ID: 114873, updated on 16-Jul-2021

Summary

Official Symbol
Dscaml1provided by MGI
Official Full Name
DS cell adhesion molecule like 1provided by MGI
Primary source
MGI:MGI:2150309
See related
Ensembl:ENSMUSG00000032087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BB239540; mKIAA1132; 4921507G06Rik; 4930435C18Rik
Expression
Biased expression in frontal lobe adult (RPKM 8.0), CNS E18 (RPKM 7.0) and 8 other tissues See more
Orthologs
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Genomic context

See Dscaml1 in Genome Data Viewer
Location:
9; 9 A5.2
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45338735..45665011)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45427433..45753713)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (45238376..45561796)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118567699 Neighboring gene RIKEN cDNA 4833428L15 gene Neighboring gene FXYD domain-containing ion transport regulator 6 Neighboring gene FXYD domain-containing ion transport regulator 2 Neighboring gene predicted gene, 22069 Neighboring gene centrosomal protein 164 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in brain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendrite self-avoidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Down syndrome cell adhesion molecule-like protein 1 homolog
Names
Down syndrome cell adhesion molecule like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081270.2NP_001074739.2  Down syndrome cell adhesion molecule-like protein 1 homolog precursor

    Status: VALIDATED

    Source sequence(s)
    AC119237, AC126804, AC159893, AC174644
    Consensus CDS
    CCDS40608.1
    Related
    ENSMUSP00000034592.10, ENSMUST00000034592.11
    Conserved Domains (7) summary
    cd05734
    Location:707785
    Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
    smart00408
    Location:519577
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:13841474
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:13071377
    Ig; Immunoglobulin domain
    pfam07679
    Location:226311
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:317389
    Ig_3; Immunoglobulin domain
    cl11960
    Location:803891
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45338735..45665011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313109.2XP_017168598.1  Down syndrome cell adhesion molecule-like protein 1 homolog isoform X2

    Conserved Domains (8) summary
    cd05734
    Location:571649
    Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
    smart00408
    Location:383441
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:12481338
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:11711241
    Ig; Immunoglobulin domain
    pfam00041
    Location:9571040
    fn3; Fibronectin type III domain
    pfam07679
    Location:97175
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:181253
    Ig_3; Immunoglobulin domain
    cl11960
    Location:667755
    Ig; Immunoglobulin domain
  2. XM_006509947.3XP_006510010.1  Down syndrome cell adhesion molecule-like protein 1 homolog isoform X1

    Conserved Domains (8) summary
    cd05734
    Location:666744
    Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
    smart00408
    Location:478536
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:13431433
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:12661336
    Ig; Immunoglobulin domain
    pfam00041
    Location:11701233
    fn3; Fibronectin type III domain
    pfam07679
    Location:291369
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:375447
    Ig_3; Immunoglobulin domain
    cl11960
    Location:762850
    Ig; Immunoglobulin domain
  3. XM_036154570.1XP_036010463.1  Down syndrome cell adhesion molecule-like protein 1 homolog isoform X3

    Conserved Domains (7) summary
    cd00063
    Location:874964
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:583669
    fn3; Fibronectin type III domain
    pfam13927
    Location:781857
    Ig_3; Immunoglobulin domain
    cd00096
    Location:37
    Ig; Ig strand A' [structural motif]
    cd05734
    Location:179275
    Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
    cd05735
    Location:276376
    Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)
    cl11960
    Location:183
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_029039.2: Suppressed sequence

    Description
    NM_029039.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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