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Plcz1 phospholipase C, zeta 1 [ Mus musculus (house mouse) ]

Gene ID: 114875, updated on 6-Sep-2021

Summary

Official Symbol
Plcz1provided by MGI
Official Full Name
phospholipase C, zeta 1provided by MGI
Primary source
MGI:MGI:2150308
See related
Ensembl:ENSMUSG00000030230
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PLCzeta; 1700041H07Rik
Expression
Restricted expression toward testis adult (RPKM 21.0) See more
Orthologs
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Genomic context

See Plcz1 in Genome Data Viewer
Location:
6; 6 G2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (139933118..139987188, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (139987396..140041488, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (139938243..139989938, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma Neighboring gene predicted gene, 53305 Neighboring gene capping protein (actin filament) muscle Z-line, alpha 3 Neighboring gene predicted gene, 44156

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC123405, MGC123406

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within egg activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in egg activation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within single fertilization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm head ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Names
PLC-zeta-1
phosphoinositide phospholipase C-zeta-1
phospholipase C zeta
NP_473407.2
XP_006506962.1
XP_006506963.1
XP_006506964.1
XP_006506965.1
XP_006506967.1
XP_017176832.1
XP_030110971.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054066.4NP_473407.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

    See identical proteins and their annotated locations for NP_473407.2

    Status: PROVISIONAL

    Source sequence(s)
    AC158625
    Consensus CDS
    CCDS20671.1
    UniProtKB/Swiss-Prot
    Q8K4D7
    Related
    ENSMUSP00000032356.7, ENSMUST00000032356.13
    Conserved Domains (4) summary
    cd00275
    Location:519644
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02952
    Location:79642
    PLN02952; phosphoinositide phospholipase C
    pfam09279
    Location:80162
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:162489
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    139933118..139987188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506899.5XP_006506962.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1

    Conserved Domains (3) summary
    PLN02952
    Location:79614
    PLN02952; phosphoinositide phospholipase C
    pfam13499
    Location:2173
    EF-hand_7; EF-hand domain pair
    cl14615
    Location:162489
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  2. XM_017321343.3XP_017176832.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4

    Conserved Domains (4) summary
    cd00275
    Location:409527
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd15898
    Location:740
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:240
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl14615
    Location:52379
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  3. XM_006506902.5XP_006506965.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4

    Conserved Domains (4) summary
    cd00275
    Location:409527
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd15898
    Location:740
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:240
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl14615
    Location:52379
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  4. XM_006506904.5XP_006506967.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X6

    Conserved Domains (2) summary
    PLN02952
    Location:1347
    PLN02952; phosphoinositide phospholipase C
    cl14615
    Location:1222
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  5. XM_006506900.5XP_006506963.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2

    Conserved Domains (3) summary
    PLN02952
    Location:79614
    PLN02952; phosphoinositide phospholipase C
    pfam13499
    Location:2173
    EF-hand_7; EF-hand domain pair
    cl14615
    Location:162489
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  6. XM_006506901.5XP_006506964.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    Conserved Domains (3) summary
    PLN02952
    Location:79619
    PLN02952; phosphoinositide phospholipase C
    pfam13499
    Location:2573
    EF-hand_7; EF-hand domain pair
    cl14615
    Location:162489
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  7. XM_030255111.2XP_030110971.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X5

    Conserved Domains (2) summary
    PLN02222
    Location:7532
    PLN02222; phosphoinositide phospholipase C 2
    cl14615
    Location:52379
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
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