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Adam2 a disintegrin and metallopeptidase domain 2 [ Mus musculus (house mouse) ]

Gene ID: 11495, updated on 23-Jun-2021

Summary

Official Symbol
Adam2provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 2provided by MGI
Primary source
MGI:MGI:1340894
See related
Ensembl:ENSMUSG00000022039
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ftn; Ftnb; Ph30-be; AI323749; Ph30-beta
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is predominantly expressed in the epididymis, where the encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Male mice lacking the encoded protein are infertile and exhibit multiple defects in reproduction. [provided by RefSeq, May 2016]
Expression
Restricted expression toward testis adult (RPKM 65.0) See more
Orthologs
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Genomic context

See Adam2 in Genome Data Viewer
Location:
14 D1; 14 34.36 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66264771..66315300, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66027322..66077851, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66646166..66696570, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene clusterin Neighboring gene gulonolactone (L-) oxidase Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene epoxide hydrolase 2, cytoplasmic Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 2
Names
a disintegrin and metalloprotease domain 2 (fertilin beta)
fertilin subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009618.3NP_033748.2  disintegrin and metalloproteinase domain-containing protein 2 preproprotein

    See identical proteins and their annotated locations for NP_033748.2

    Status: REVIEWED

    Source sequence(s)
    AC126444, AK016550, BY094547
    Consensus CDS
    CCDS36959.1
    UniProtKB/Swiss-Prot
    Q60718
    Related
    ENSMUSP00000022618.6, ENSMUST00000022618.6
    Conserved Domains (5) summary
    smart00608
    Location:475610
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:185379
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:398469
    Disintegrin; Disintegrin
    pfam01421
    Location:184381
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40146
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    66264771..66315300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518439.4XP_006518502.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00608
    Location:451586
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:374445
    Disintegrin
    pfam01421
    Location:184357
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:32147
    Pep_M12B_propep; Reprolysin family propeptide
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