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Adam22 a disintegrin and metallopeptidase domain 22 [ Mus musculus (house mouse) ]

Gene ID: 11496, updated on 21-Apr-2024

Summary

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Official Symbol
Adam22provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 22provided by MGI
Primary source
MGI:MGI:1340046
See related
Ensembl:ENSMUSG00000040537 AllianceGenome:MGI:1340046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDC2; 2900022I03Rik
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit severe ataxia, hypomyelination and premature death. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
Expression
Biased expression in cerebellum adult (RPKM 18.0), cortex adult (RPKM 14.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A1; 5 3.39 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8122353..8418312, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8072347..8368312, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15731 Neighboring gene predicted gene, 52802 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12380 Neighboring gene sorcin Neighboring gene STARR-seq mESC enhancer starr_12381 Neighboring gene predicted gene, 21759 Neighboring gene STARR-seq mESC enhancer starr_12382 Neighboring gene STARR-seq mESC enhancer starr_12383 Neighboring gene predicted gene, 23993 Neighboring gene STARR-seq mESC enhancer starr_12384 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12387 Neighboring gene solute carrier family 25, member 40 Neighboring gene DBF4 zinc finger Neighboring gene STARR-positive B cell enhancer mm9_chr5:8489752-8490052 Neighboring gene STARR-seq mESC enhancer starr_12390 Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B member 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. miR-221-3p inhibits oxidized low-density lipoprotein induced oxidative stress and apoptosis via targeting a disintegrin and metalloprotease-22. Zhuang X, et al. J Cell Biochem, 2019 Apr. PMID 30362166
  2. A Disintegrin and Metalloprotease-22 Attenuates Hypertrophic Remodeling in Mice Through Inhibition of the Protein Kinase B Signaling Pathway. Ren L, et al. J Am Heart Assoc, 2018 Jan 22. PMID 29358191, Free PMC Article
  3. LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11. Sagane K, et al. Int J Biol Sci, 2008. PMID 18974846, Free PMC Article
  4. LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention. Fukata Y, et al. Proc Natl Acad Sci U S A, 2021 Jan 19. PMID 33397806, Free PMC Article
  5. The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function. Lovero KL, et al. Proc Natl Acad Sci U S A, 2015 Jul 28. PMID 26178195, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A disintegrin and metalloproteinase 22 activates integrin beta1 through its disintegrin domain to promote the progression of pituitary adenoma.
    Title: A disintegrin and metalloproteinase 22 activates integrin β1 through its disintegrin domain to promote the progression of pituitary adenoma.
  2. LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention.
    Title: LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention.
  3. Results have identified ADAM22 as the most potential target of miR-221, and silencing ADAM22 resulted in a reduced foam cell formation and cell apoptosis.
    Title: miR-221-3p inhibits oxidized low-density lipoprotein induced oxidative stress and apoptosis via targeting a disintegrin and metalloprotease-22.
  4. ADAM22 negatively regulates cardiac myocyte AKT activation and the process of cardiac hypertrophy.
    Title: A Disintegrin and Metalloprotease-22 Attenuates Hypertrophic Remodeling in Mice Through Inhibition of the Protein Kinase B Signaling Pathway.
  5. LGI1 and ADAM22 form an essential synaptic organizing complex that coordinates the maturation of excitatory synapses by regulating the functional incorporation of PSD-95
    Title: The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function.
  6. Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs).
    Title: Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.
  7. ADAM22 is an axonal component of the Kv1 K+ channel complex that recruits membrane-associated guanylate kinase to juxtaparanodes
    Title: ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.
  8. study identified LGI1 as a specific binding partner of ADAM22 protein from mouse brain, and demonstrated the specific interaction between LGI1 and ADAM22
    Title: LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11.
  9. ADAM22 is closely involved in the correct functioning of the nervous system.
    Title: Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gliogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon initial segment ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 22
Names
a disintegrin and metalloprotease domain (ADAM) 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007220.4 → NP_001007221.1  disintegrin and metalloproteinase domain-containing protein 22 isoform a precursor

    See identical proteins and their annotated locations for NP_001007221.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as alpha or A04) encodes isoform a. This isoform (a) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AC140364, AC152165, AC156022
    Consensus CDS
    CCDS19080.1
    UniProtKB/TrEMBL
    A4FUT9
    Related
    ENSMUSP00000049120.8, ENSMUST00000046838.14
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237 → 434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451 → 525
    Disintegrin; Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73 → 185
    Pep_M12B_propep; Reprolysin family propeptide

  2. NM_001007221.4 → NP_001007222.1  disintegrin and metalloproteinase domain-containing protein 22 isoform b precursor

    See identical proteins and their annotated locations for NP_001007222.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as beta or A05) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. This isoform (b) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AC140364, AC152165, AC156022
    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237 → 434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451 → 525
    Disintegrin; Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73 → 185
    Pep_M12B_propep; Reprolysin family propeptide

  3. NM_001098225.3 → NP_001091695.1  disintegrin and metalloproteinase domain-containing protein 22 isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as G03) contains multiple differences in the 3' coding region and differs in the 3' UTR compared variant 1. The encoded isoform (c) has a distinct C-terminus and is longer than isoform a. This isoform (c) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AC140364, AC152165, AC156022
    Consensus CDS
    CCDS51411.1
    UniProtKB/TrEMBL
    A4FUT9
    Related
    ENSMUSP00000055000.8, ENSMUST00000050166.14
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237 → 434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451 → 525
    Disintegrin; Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73 → 185
    Pep_M12B_propep; Reprolysin family propeptide

  4. NM_001310439.2 → NP_001297368.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as G07) contains multiple differences in the 3' coding region and differs in the 3' UTR compared variant 1. The encoded isoform (c) has a distinct C-terminus and is longer than isoform a. This isoform (4) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AC140364, AC152165, AC156022
    Consensus CDS
    CCDS80205.1
    UniProtKB/TrEMBL
    A4FUT9
    Related
    ENSMUSP00000111046.3, ENSMUST00000115388.9
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237 → 434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451 → 525
    Disintegrin; Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73 → 185
    Pep_M12B_propep; Reprolysin family propeptide

  5. NM_001310440.2 → NP_001297369.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 5 preproprotein

    See identical proteins and their annotated locations for NP_001297369.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as G01) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (c) has a longer C-terminus than isoform a.
    Source sequence(s)
    AC140364, AC152165, AC156022
    Consensus CDS
    CCDS80207.1
    UniProtKB/Swiss-Prot
    Q5TLI8, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5, Q9R1V6
    UniProtKB/TrEMBL
    A4FUT9, D6QSS8
    Related
    ENSMUSP00000086139.5, ENSMUST00000088761.11
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237 → 434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451 → 525
    Disintegrin; Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73 → 185
    Pep_M12B_propep; Reprolysin family propeptide

  6. NM_001418085.1 → NP_001405014.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC140364, AC152165, AC156022

  7. NM_001418086.1 → NP_001405015.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC140364, AC152165, AC156022

  8. NM_001418087.1 → NP_001405016.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC140364, AC152165, AC156022
    UniProtKB/TrEMBL
    D3YUQ0
    Related
    ENSMUSP00000111043.2, ENSMUST00000115385.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    8122353..8418312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503534.5 → XP_006503597.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677 → 709
    EGF_2; EGF-like domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_006503540.5 → XP_006503603.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

    UniProtKB/TrEMBL
    A4FUT9, D3YUP9
    Related
    ENSMUSP00000111044.2, ENSMUST00000115386.8
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677 → 709
    EGF_2; EGF-like domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  3. XM_006503536.5 → XP_006503599.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677 → 709
    EGF_2; EGF-like domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  4. XM_006503537.5 → XP_006503600.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677 → 709
    EGF_2; EGF-like domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  5. XM_006503532.5 → XP_006503595.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677 → 709
    EGF_2; EGF-like domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  6. XM_006503533.5 → XP_006503596.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677 → 709
    EGF_2; EGF-like domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  7. XM_006503530.5 → XP_006503593.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677 → 709
    EGF_2; EGF-like domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  8. XM_006503528.5 → XP_006503591.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677 → 709
    EGF_2; EGF-like domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  9. XM_006503535.5 → XP_006503598.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (4) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  10. XM_006503531.5 → XP_006503594.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677 → 709
    EGF_2; EGF-like domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  11. XM_006503529.5 → XP_006503592.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677 → 709
    EGF_2; EGF-like domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  12. XM_030254064.2 → XP_030109924.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (4) summary
    smart00608
    Location:528 → 669
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:451 → 524
    Disintegrin
    pfam01421
    Location:237 → 436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48 → 186
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. XR_376691.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1V6.2 GenPept UniProtKB/Swiss-Prot:Q9R1V6

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