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WDR31 WD repeat domain 31 [ Homo sapiens (human) ]

Gene ID: 114987, updated on 23-Nov-2021

Summary

Official Symbol
WDR31provided by HGNC
Official Full Name
WD repeat domain 31provided by HGNC
Primary source
HGNC:HGNC:21421
See related
Ensembl:ENSG00000148225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 3.6), thyroid (RPKM 2.8) and 24 other tissues See more
Orthologs
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Genomic context

See WDR31 in Genome Data Viewer
Location:
9q32
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (113313222..113340326, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116075502..116102555, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 4 Neighboring gene ring finger protein 183 Neighboring gene B-box and SPRY domain containing Neighboring gene haloacid dehalogenase like hydrolase domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35921

General protein information

Preferred Names
WD repeat-containing protein 31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006615.3NP_001006616.1  WD repeat-containing protein 31 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AI091187, AK074891, AL449305, DA209351
    UniProtKB/TrEMBL
    Q8NC90
    Conserved Domains (3) summary
    COG2319
    Location:2218
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2459
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:5225
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001012361.4NP_001012361.1  WD repeat-containing protein 31 isoform 1

    See identical proteins and their annotated locations for NP_001012361.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI091187, AK093240, AL449305, DA209351
    Consensus CDS
    CCDS35110.1
    UniProtKB/Swiss-Prot
    Q8NA23
    UniProtKB/TrEMBL
    A0A024R876
    Related
    ENSP00000363308.3, ENST00000374193.9
    Conserved Domains (3) summary
    COG2319
    Location:61343
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:61350
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:65101
    7WD40; WD40 repeat [structural motif]
  3. NM_145241.5NP_660284.1  WD repeat-containing protein 31 isoform 3

    See identical proteins and their annotated locations for NP_660284.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 3 which lacks one internal amino acid, compared to isoform 1.
    Source sequence(s)
    AI091187, AL449305, BC012352, DA209351
    Consensus CDS
    CCDS6792.1
    UniProtKB/Swiss-Prot
    Q8NA23
    Related
    ENSP00000345027.3, ENST00000341761.8
    Conserved Domains (2) summary
    cd00200
    Location:60349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:64100
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_134677.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses alternate splice sites in two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI091187, AL449305, AL833635, DA209351

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    113313222..113340326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518194.2XP_011516496.1  WD repeat-containing protein 31 isoform X1

    See identical proteins and their annotated locations for XP_011516496.1

    Conserved Domains (3) summary
    COG2319
    Location:88318
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85119
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:61325
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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