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GBP4 guanylate binding protein 4 [ Homo sapiens (human) ]

Gene ID: 115361, updated on 30-Mar-2024

Summary

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Official Symbol
GBP4provided by HGNC
Official Full Name
guanylate binding protein 4provided by HGNC
Primary source
HGNC:HGNC:20480
See related
Ensembl:ENSG00000162654 MIM:612466; AllianceGenome:HGNC:20480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mpa2
Summary
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
Expression
Broad expression in lung (RPKM 16.3), lymph node (RPKM 13.8) and 23 other tissues See more
Orthologs
all
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Genomic context

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Location:
1p22.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (89181144..89198942, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (89024523..89042320, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89646827..89664625, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268267 Neighboring gene Sharpr-MPRA regulatory region 4932 Neighboring gene guanylate binding protein 2 Neighboring gene uncharacterized LOC105378842 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:89614414-89615613 Neighboring gene guanylate binding protein 7 Neighboring gene uncharacterized LOC107985076 Neighboring gene Sharpr-MPRA regulatory region 13956 Neighboring gene guanylate binding protein family member 6 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:89725724-89726225 Neighboring gene guanylate binding protein 5 Neighboring gene intraflagellar transport associated protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The guanylate-binding proteins (GBPs): proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. Vestal DJ. J Interferon Cytokine Res, 2005 Aug. PMID 16108726
  2. Cloning, expression, and characterization of a novel guanylate-binding protein, GBP3 in murine erythroid progenitor cells. Han BH, et al. Biochim Biophys Acta, 1998 May 19. PMID 9659399
  3. Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner. Britzen-Laurent N, et al. PLoS One, 2010 Dec 7. PMID 21151871, Free PMC Article
  4. Unique features of different members of the human guanylate-binding protein family. Tripal P, et al. J Interferon Cytokine Res, 2007 Jan. PMID 17266443
  5. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Olszewski MA, et al. J Interferon Cytokine Res, 2006 May. PMID 16689661

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Guanylate binding protein 4 shapes an inflamed tumor microenvironment and identifies immuno-hot tumors.
    Title: Guanylate binding protein 4 shapes an inflamed tumor microenvironment and identifies immuno-hot tumors.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of guanylate binding protein 4 (GBP4) expression as compared to untreated control PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of guanylate binding protein 4 (GBP4) in primary human brain microvascular endothelial cells PubMed
Vif vif HIV-1 Vif upregulates the expression of guanylate binding protein 4 (GBP4) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: GBP5

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to type II interferon IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
guanylate-binding protein 4
Names
GBP-4
GTP-binding protein 4
guanine nucleotide-binding protein 4
NP_443173.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052941.5 → NP_443173.2  guanylate-binding protein 4

    See identical proteins and their annotated locations for NP_443173.2

    Status: VALIDATED

    Source sequence(s)
    AC104459, AF288814, BC008421, BC070055, CA309701
    Consensus CDS
    CCDS721.1
    UniProtKB/Swiss-Prot
    B2R630, Q05D63, Q6NSL0, Q86T99, Q96PP9
    Related
    ENSP00000359490.5, ENST00000355754.7
    Conserved Domains (3) summary
    pfam02841
    Location:298 → 594
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:33 → 296
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:304 → 594
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    89181144..89198942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    89024523..89042320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PP9.2 GenPept UniProtKB/Swiss-Prot:Q96PP9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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