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Adra1a adrenergic receptor, alpha 1a [ Mus musculus (house mouse) ]

Gene ID: 11549, updated on 17-Oct-2021

Summary

Official Symbol
Adra1aprovided by MGI
Official Full Name
adrenergic receptor, alpha 1aprovided by MGI
Primary source
MGI:MGI:104773
See related
Ensembl:ENSMUSG00000045875
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adra1c
Summary
This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Expression
Biased expression in frontal lobe adult (RPKM 2.7), lung adult (RPKM 1.9) and 14 other tissues See more
Orthologs
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Genomic context

See Adra1a in Genome Data Viewer
Location:
14; 14 D1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66872700..67008689)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66635251..66771240)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (67254095..67352166)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41184 Neighboring gene VISTA enhancer mm1500 Neighboring gene uncharacterized LOC118568160 Neighboring gene predicted gene 9130

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC130524

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables alpha1-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha1-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha1-adrenergic receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables alpha1-adrenergic receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adult heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell growth involved in cardiac muscle cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in micturition ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism aging IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in multicellular organism aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron-glial cell signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within organ growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 
involved_in pilomotor reflex IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cardiac muscle hypertrophy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate by epinephrine-norepinephrine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of heart rate by epinephrine-norepinephrine IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of the force of heart contraction by epinephrine-norepinephrine IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-1A adrenergic receptor
Names
alpha-1A adrenoceptor
alpha-1A adrenoreceptor
alpha-1C adrenergic receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271759.1NP_001258688.1  alpha-1A adrenergic receptor isoform 2

    See identical proteins and their annotated locations for NP_001258688.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC129570, AK033490, AK085653
    Consensus CDS
    CCDS70600.1
    UniProtKB/TrEMBL
    Q8BUE5, Q8BZV1
    Related
    ENSMUSP00000124322.2, ENSMUST00000159365.8
    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001271760.1NP_001258689.1  alpha-1A adrenergic receptor isoform 1

    See identical proteins and their annotated locations for NP_001258689.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AK033490, AK079597, AK085653
    Consensus CDS
    CCDS27223.1
    UniProtKB/Swiss-Prot
    P97718
    UniProtKB/TrEMBL
    Q8BUE5, Q8BZV1
    Related
    ENSMUSP00000125354.2, ENSMUST00000161339.2
    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001271761.1NP_001258690.1  alpha-1A adrenergic receptor isoform 3

    See identical proteins and their annotated locations for NP_001258690.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks two exons, and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (3) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK042759, AK085653
    Consensus CDS
    CCDS88696.1
    UniProtKB/TrEMBL
    Q8BUE5, Q8BXZ4
    Related
    ENSMUSP00000153103.2, ENSMUST00000225182.2
    Conserved Domains (2) summary
    cd14964
    Location:2953
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27294
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. NM_013461.4NP_038489.2  alpha-1A adrenergic receptor isoform 1

    See identical proteins and their annotated locations for NP_038489.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AK033490, AK079597, AK085653
    Consensus CDS
    CCDS27223.1
    UniProtKB/Swiss-Prot
    P97718
    UniProtKB/TrEMBL
    Q8BUE5, Q8BZV1
    Related
    ENSMUSP00000053703.2, ENSMUST00000054661.8
    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    66872700..67008689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315800.3XP_017171289.1  alpha-1A adrenergic receptor isoform X1

    UniProtKB/Swiss-Prot
    P97718
    Related
    ENSMUSP00000124570.2, ENSMUST00000159068.2
    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_006518444.5XP_006518507.1  alpha-1A adrenergic receptor isoform X1

    See identical proteins and their annotated locations for XP_006518507.1

    UniProtKB/Swiss-Prot
    P97718
    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_011244926.4XP_011243228.1  alpha-1A adrenergic receptor isoform X2

    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_011244925.4XP_011243227.1  alpha-1A adrenergic receptor isoform X1

    See identical proteins and their annotated locations for XP_011243227.1

    UniProtKB/Swiss-Prot
    P97718
    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_006518449.5XP_006518512.1  alpha-1A adrenergic receptor isoform X4

    Conserved Domains (2) summary
    cd14964
    Location:2854
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27337
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. XM_036158409.1XP_036014302.1  alpha-1A adrenergic receptor isoform X5

    Conserved Domains (2) summary
    cd14964
    Location:2854
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27309
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  7. XM_011244923.4XP_011243225.1  alpha-1A adrenergic receptor isoform X1

    See identical proteins and their annotated locations for XP_011243225.1

    UniProtKB/Swiss-Prot
    P97718
    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. XM_011244924.4XP_011243226.1  alpha-1A adrenergic receptor isoform X1

    See identical proteins and their annotated locations for XP_011243226.1

    UniProtKB/Swiss-Prot
    P97718
    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
  9. XM_017315802.2XP_017171291.1  alpha-1A adrenergic receptor isoform X6

    UniProtKB/TrEMBL
    Q8BXZ4
    Conserved Domains (2) summary
    cd14964
    Location:2953
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27294
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  10. XM_036158407.1XP_036014300.1  alpha-1A adrenergic receptor isoform X1

    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
  11. XM_017315801.3XP_017171290.1  alpha-1A adrenergic receptor isoform X1

    UniProtKB/Swiss-Prot
    P97718
    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
  12. XM_036158408.1XP_036014301.1  alpha-1A adrenergic receptor isoform X3

    Conserved Domains (1) summary
    cd15325
    Location:27337
    7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
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