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Aebp2 AE binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 11569, updated on 23-Jun-2021

Summary

Official Symbol
Aebp2provided by MGI
Official Full Name
AE binding protein 2provided by MGI
Primary source
MGI:MGI:1338038
See related
Ensembl:ENSMUSG00000030232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AU023766; B230313N05Rik
Expression
Ubiquitous expression in limb E14.5 (RPKM 9.4), CNS E11.5 (RPKM 7.5) and 28 other tissues See more
Orthologs
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Genomic context

See Aebp2 in Genome Data Viewer
Location:
6; 6 G2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (140567480..140624198)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (140622454..140678472)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (140571184..140625939)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A member 5 Neighboring gene predicted gene 5051 Neighboring gene predicted gene, 30215 Neighboring gene ribosomal protein L38, pseudogene 2 Neighboring gene predicted gene, 30524 Neighboring gene ribosomal protein L11 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein AEBP2
Names
adipocyte enhancer-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005605.2NP_001005605.1  zinc finger protein AEBP2 isoform 1

    See identical proteins and their annotated locations for NP_001005605.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC133098, AK045838
    Consensus CDS
    CCDS20673.1
    UniProtKB/Swiss-Prot
    Q9Z248
    Related
    ENSMUSP00000084896.5, ENSMUST00000087614.11
    Conserved Domains (2) summary
    COG5048
    Location:210332
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259279
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001309436.1NP_001296365.1  zinc finger protein AEBP2 isoform 4

    See identical proteins and their annotated locations for NP_001296365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR, alternate 3' coding region and cause translation initiation at a downstream start codon, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and distinct C-terminus, compared to isoform 1. Both variants 4 and 5 encode the same protein (isoform 4).
    Source sequence(s)
    AC133098, AK045838
    Consensus CDS
    CCDS80631.1
    UniProtKB/Swiss-Prot
    Q9Z248
    Related
    ENSMUSP00000125479.2, ENSMUST00000161335.8
    Conserved Domains (2) summary
    COG5048
    Location:3110
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3757
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001309437.1NP_001296366.1  zinc finger protein AEBP2 isoform 4

    See identical proteins and their annotated locations for NP_001296366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR, alternate 3' coding region and cause translation initiation at a downstream start codon, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and distinct C-terminus, compared to isoform 1. Both variants 4 and 5 encode the same protein (isoform 4).
    Source sequence(s)
    AC133098, AK045838
    Consensus CDS
    CCDS80631.1
    UniProtKB/Swiss-Prot
    Q9Z248
    Related
    ENSMUSP00000124148.2, ENSMUST00000160836.8
    Conserved Domains (2) summary
    COG5048
    Location:3110
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3757
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_009637.4NP_033767.2  zinc finger protein AEBP2 isoform 3

    See identical proteins and their annotated locations for NP_033767.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is longer and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB221647, AC133098
    Consensus CDS
    CCDS39689.2
    UniProtKB/Swiss-Prot
    Q9Z248
    Related
    ENSMUSP00000092993.6, ENSMUST00000095350.11
    Conserved Domains (3) summary
    COG5048
    Location:210332
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:308334
    zf-H2C2_2; Zinc-finger double domain
  5. NM_178803.2NP_848918.1  zinc finger protein AEBP2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.
    Source sequence(s)
    AC133098, AEKQ02102408
    Consensus CDS
    CCDS20674.1
    UniProtKB/Swiss-Prot
    Q9Z248
    Related
    ENSMUSP00000032359.9, ENSMUST00000032359.15
    Conserved Domains (2) summary
    COG5048
    Location:3110
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3757
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    140567480..140624198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506909.4XP_006506972.1  zinc finger protein AEBP2 isoform X3

    See identical proteins and their annotated locations for XP_006506972.1

    UniProtKB/Swiss-Prot
    Q9Z248
    Conserved Domains (2) summary
    COG5048
    Location:3110
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3757
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_006506905.3XP_006506968.1  zinc finger protein AEBP2 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:210332
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:308334
    zf-H2C2_2; Zinc-finger double domain
  3. XM_006506906.1XP_006506969.1  zinc finger protein AEBP2 isoform X2

    See identical proteins and their annotated locations for XP_006506969.1

    UniProtKB/Swiss-Prot
    Q9Z248
    Conserved Domains (2) summary
    COG5048
    Location:210332
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259279
    ZF_C2H2; C2H2 Zn finger [structural motif]
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