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Angpt2 angiopoietin 2 [ Mus musculus (house mouse) ]

Gene ID: 11601, updated on 11-Jul-2021

Summary

Official Symbol
Angpt2provided by MGI
Official Full Name
angiopoietin 2provided by MGI
Primary source
MGI:MGI:1202890
See related
Ensembl:ENSMUSG00000031465
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
An; Ang; Ang2; Agpt2; Ang-2
Summary
This gene encodes an endothelial cell (EC)-derived regulator of angiogenesis and ligand for endothelial-specific receptor tyrosine kinase. The encoded protein acts as an anti-apoptotic factor for stressed ECs and a proapoptotic factor for resting ECs. [provided by RefSeq, Jan 2013]
Expression
Broad expression in placenta adult (RPKM 8.9), kidney adult (RPKM 5.7) and 19 other tissues See more
Orthologs
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Genomic context

See Angpt2 in Genome Data Viewer
Location:
8 A1.3; 8 10.3 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (18740279..18791578, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (18690263..18741562, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (18691337..18741551, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microcephaly, primary autosomal recessive 1 Neighboring gene predicted gene, 25763 Neighboring gene predicted gene 17149 Neighboring gene predicted gene, 53403 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor antagonist activity TAS
Traceable Author Statement
more info
PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in Tie signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Tie signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Tie signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in Tie signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel remodeling TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endoderm development TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in glomerulus vasculature development ISO
Inferred from Sequence Orthology
more info
 
involved_in hemopoiesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007426.4NP_031452.2  angiopoietin-2 precursor

    See identical proteins and their annotated locations for NP_031452.2

    Status: REVIEWED

    Source sequence(s)
    AC122206, BC138309, CJ182273, CN539462
    Consensus CDS
    CCDS22125.1
    UniProtKB/Swiss-Prot
    O35608
    UniProtKB/TrEMBL
    B9EHQ4
    Related
    ENSMUSP00000033846.6, ENSMUST00000033846.7
    Conserved Domains (2) summary
    smart00186
    Location:280494
    FBG; Fibrinogen-related domains (FReDs)
    cl23720
    Location:168226
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    18740279..18791578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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