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LOC116158495 CRISPRi-validated cis-regulatory element chr4.1814 [ Homo sapiens (human) ]

Gene ID: 116158495, updated on 10-Jun-2021

Summary

Gene symbol
LOC116158495
Gene description
CRISPRi-validated cis-regulatory element chr4.1814
Gene type
biological region
Feature type(s)
regulatory: transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region represents a DNase I hypersensitive site (DHS) that was predicted to be an enhancer by the ENCODE (ENCyclopedia Of DNA Elements) project based on various combinations of H3K27 acetylation and binding of p300, GATA1 and RNA polymerase II in K562 erythroleukemia cells. It was validated as a high-confidence cis-regulatory element for both the CXCL2 (C-X-C motif chemokine ligand 2) and CXCL3 (C-X-C motif chemokine ligand 3) genes on chromosome 4 based on multiplex CRISPR/Cas9-mediated perturbation in K562 cells. Both target genes are involved in immune response or antiviral activity and are thus relevant for COVID-19 research. [provided by RefSeq, Jun 2021]
Annotation information
Note: This locus has been reviewed for its involvement in coronavirus biology, and is involved in host gene regulation.
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Genomic context

See LOC116158495 in Genome Data Viewer
Location:
4q
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (74057709..74057893)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (74923426..74923610)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr4.1813 Neighboring gene pro-platelet basic protein pseudogene 2 Neighboring gene coiled-coil domain containing 90B pseudogene Neighboring gene C-X-C motif chemokine ligand 2

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_066637.1 

    Range
    101..285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    74057709..74057893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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