Alppl2 alkaline phosphatase, placental-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alppl2provided by MGI
Official Full Name: alkaline phosphatase, placental-like 2provided by MGI
Primary source: MGI:MGI:108009
See related: Ensembl:ENSMUSG00000026246 AllianceGenome:MGI:108009
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EAP; Akp5; Alpg; D1Ertd816e
Summary: Enables alkaline phosphatase activity. Predicted to be involved in dephosphorylation. Located in myofibril. Is expressed in early conceptus; intestine; and testis. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 7.5), testis adult (RPKM 2.2) and 3 other tissues See more
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Genomic context

Location:: 1 C5; 1 44.05 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (87014412..87023656, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (87086690..87095934, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Akp5 (e-PCR), detects polymorphism
- UniSTS:141065

RH136468 (e-PCR)
- UniSTS:210453

D1Ertd816e (e-PCR), detects polymorphism
- UniSTS:167298

C77216 (e-PCR)
- UniSTS:178430

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alkaline phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkaline phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables alkaline phosphatase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alkaline phosphatase, germ cell type

Names: alkaline phosphatase 5; embryonic alkaline phosphatase; embryonic-type alkaline phosphatase

NP_031459.3

EC 3.1.3.1

XP_006529145.1

EC 3.1.3.1

XP_011246206.1

EC 3.1.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.