Nup107 nucleoporin 107 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nup107provided by RGD
Official Full Name: nucleoporin 107provided by RGD
Primary source: RGD:621160
See related: Ensembl:ENSRNOG00000006541 AllianceGenome:RGD:621160
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including nuclear pore complex assembly; nucleocytoplasmic transport; and posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Located in nuclear membrane. Part of nuclear pore. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome; nephrotic syndrome type 11; and ovarian dysgenesis 6. Orthologous to human NUP107 (nucleoporin 107). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 124.7), Spleen (RPKM 85.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (55239610..55285050, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (53353740..53398345, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (60781724..60825225, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The analysis for the protein production demonstrated Nup107-facilitated transport of Scn5a mRNA. Using RIP-PCR and luciferase assay, we found that the 5'-UTR of Scn5a mRNA was not involved in the interaction, whereas the spatial interaction between Nup107 protein and Scn5a mRNA was formed when Scn5a mRNA passing through the nuclear pore.
Title: Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity.

Submit: New GeneRIF Correction

General gene information

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Markers

BI288689 (e-PCR)
- UniSTS:246295

RH131443 (e-PCR)
- UniSTS:214726

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	ISO Inferred from Sequence Orthology more info
enables structural constituent of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in female gonad development	IEA Inferred from Electronic Annotation more info
involved_in female gonad development	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nephron development	IEA Inferred from Electronic Annotation more info
involved_in nephron development	ISO Inferred from Sequence Orthology more info
involved_in nephron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear pore complex assembly	IEA Inferred from Electronic Annotation more info
involved_in nuclear pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in nuclear pore complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear periphery	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	ISO Inferred from Sequence Orthology more info
located_in nuclear periphery	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of nuclear pore outer ring	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore outer ring	IEA Inferred from Electronic Annotation more info
part_of nuclear pore outer ring	ISO Inferred from Sequence Orthology more info
part_of nuclear pore outer ring	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nuclear pore complex protein Nup107

Names: 107 kDa nucleoporin; nucleoporin Nup107; p105

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053830.2 → NP_446282.2 nuclear pore complex protein Nup107

See identical proteins and their annotated locations for NP_446282.2

Status: VALIDATED

Source sequence(s)

BQ191246, C07146, CB733157, CB775175, CB792533, CK844566, CV120917, EV764995, JAXUCZ010000007

UniProtKB/Swiss-Prot

P52590

UniProtKB/TrEMBL

A6IGT7

Related

ENSRNOP00000009203.7, ENSRNOT00000009203.7

Conserved Domains (1) summary

pfam04121
Location:209 → 908

Nup84_Nup100; Nuclear pore protein 84 / 107

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

55239610..55285050 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262867.1 → XP_063118937.1 nuclear pore complex protein Nup107 isoform X1

UniProtKB/Swiss-Prot

P52590
XM_063262868.1 → XP_063118938.1 nuclear pore complex protein Nup107 isoform X2

UniProtKB/TrEMBL

A0A8I6AQT4