Fcgr2a Fc gamma receptor 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fcgr2aprovided by RGD
Official Full Name: Fc gamma receptor 2Aprovided by RGD
Primary source: RGD:71069
See related: Ensembl:ENSRNOG00000049422 AllianceGenome:RGD:71069
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fcgr3; Fcgr3a; fcRIII; fc-gamma RIII
Summary: Enables immunoglobulin receptor binding activity. Involved in several processes, including regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of antibody-dependent cellular cytotoxicity; and regulation of tumor necrosis factor production. Located in cell surface. Used to study crescentic glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to human FCGR2A (Fc fragment of IgG receptor IIa). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 190.3), Spleen (RPKM 115.7) and 9 other tissues See more
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Genomic context

Location:: 13q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (85813516..85830269, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (83280782..83297535, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (91146878..91163691, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration.
Title: Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration.
the mechanism by which the deletion of Fcgr3-rs in the WKY strain leads to increased macrophage activation
Title: Role of novel rat-specific Fc receptor in macrophage activation associated with crescentic glomerulonephritis.
copy number variation of the orthologous rat and human Fcgr3 genes is a determinant of susceptibility to immunologically mediated glomerulonephritis
Title: Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans.

Submit: New GeneRIF Correction

General gene information

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Markers

D13Arb12 (e-PCR)
- UniSTS:239639

RH128796 (e-PCR)
- UniSTS:212104

D13Got71 (e-PCR)
- UniSTS:115635

Fcgr3 (e-PCR), detects polymorphism
- UniSTS:143084

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgG binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgG binding	ISO Inferred from Sequence Orthology more info
enables IgG receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables IgG receptor activity	ISO Inferred from Sequence Orthology more info
enables immunoglobulin receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in antibody-dependent cellular cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antibody-dependent cellular cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in nerve development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis, recognition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type I hypersensitivity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type III hypersensitivity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity	ISO Inferred from Sequence Orthology more info
involved_in regulation of Fc receptor mediated stimulatory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of antibody-dependent cellular cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within serotonin secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: low affinity immunoglobulin gamma Fc region receptor III

Names: Fc fragment of IgG low affinity IIa receptor for (CD32); Fc fragment of IgG receptor IIa; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc gamma receptor IIa; Fc receptor, IgG, low affinity III; igG Fc receptor III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419015.1 → NP_001405944.1 low affinity immunoglobulin gamma Fc region receptor III isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8L2Q236

Related

ENSRNOP00000004204.7, ENSRNOT00000004204.7
NM_001419016.1 → NP_001405945.1 low affinity immunoglobulin gamma Fc region receptor III isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_053843.4 → NP_446295.2 low affinity immunoglobulin gamma Fc region receptor III isoform 1

See identical proteins and their annotated locations for NP_446295.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I6AAT3, A0A8L2Q236

Related

ENSRNOP00000089656.1, ENSRNOT00000096873.1

Conserved Domains (2) summary

smart00410
Location:129 → 205

IG_like; Immunoglobulin like

cl11960
Location:123 → 205

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

85813516..85830269 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250305.5 → XP_006250367.1 low affinity immunoglobulin gamma Fc region receptor III isoform X1

See identical proteins and their annotated locations for XP_006250367.1

UniProtKB/TrEMBL

A0A8I6AAT3, A0A8L2Q236

Conserved Domains (2) summary

smart00410
Location:129 → 205

IG_like; Immunoglobulin like

cl11960
Location:123 → 205

Ig; Immunoglobulin domain
XM_039090270.2 → XP_038946198.1 low affinity immunoglobulin gamma Fc region receptor III isoform X3

Conserved Domains (2) summary

cd00096
Location:123 → 127

Ig; Ig strand A [structural motif]

cl11960
Location:123 → 205

Ig; Immunoglobulin domain
XM_039090269.2 → XP_038946197.1 low affinity immunoglobulin gamma Fc region receptor III isoform X2

UniProtKB/TrEMBL

A0A8I6AAT3, A0A8I6AP20

Related

ENSRNOP00000095599.1

Conserved Domains (2) summary

cd00096
Location:116 → 120

Ig; Ig strand A [structural motif]

cl11960
Location:116 → 198

Ig; Immunoglobulin domain
XM_063271963.1 → XP_063128033.1 low affinity immunoglobulin gamma Fc region receptor III isoform X1

UniProtKB/TrEMBL

A0A8L2Q236
XM_063271962.1 → XP_063128032.1 low affinity immunoglobulin gamma Fc region receptor III isoform X1

UniProtKB/TrEMBL

A0A8L2Q236
XM_039090273.2 → XP_038946201.1 low affinity immunoglobulin gamma Fc region receptor III isoform X4

Conserved Domains (2) summary

cd00096
Location:42 → 45

Ig; Ig strand A [structural motif]

cl11960
Location:41 → 119

Ig; Immunoglobulin domain