Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif4ebp1provided by RGD
Official Full Name: eukaryotic translation initiation factor 4E binding protein 1provided by RGD
Primary source: RGD:620259
See related: Ensembl:ENSRNOG00000012582 AllianceGenome:RGD:620259
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PHAS-I
Summary: Enables eukaryotic initiation factor 4E binding activity and protein phosphatase 2A binding activity. Involved in several processes, including response to amino acid starvation; response to ethanol; and response to ischemia. Located in cytoplasm and nucleus. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study tuberous sclerosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 227.9), Heart (RPKM 195.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (71495457..71508845, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (64792595..64805984, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (68954860..68968248, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mTOR inhibitor improves testosterone-induced myocardial hypertrophy in hypertensive rats.
Title: mTOR inhibitor improves testosterone-induced myocardial hypertrophy in hypertensive rats.
These results indicate that a low-protein diet increases the amount of 4E-BP1, leading to TG accumulation in rat liver. We thus conclude that 4E-BP1 plays an important role in inducing hepatic steatosis under protein deprivation.
Title: A translation repressor, 4E-BP1, regulates the triglyceride level in rat liver during protein deprivation.
In an anterior cruciate ligament transection model of osteoarthritis, 4E-BP1 inactivation precedes cartilage degeneration and increased expression of pathogenic proteases in cartilage.
Title: mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.
FGF signaling differentially impacts protein synthesis through either stimulation or repression, in a cell-type-dependent manner, with 4E-BP1 being a key player.
Title: Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP.
Suggest that 4-nonylphenol stimulates Sertoli cell autophagy and inhibits mTOR-p70S6K/4EBP1 activity through AMPK activation.
Title: 4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.
mTOR plays an important role in spermatogenesis by regulating p70s6k activation; 4e-bp1 is either directly or indirectly regulated by PI3K
Title: mTOR/P70S6K promotes spermatogonia proliferation and spermatogenesis in Sprague Dawley rats.
Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, resulting in caspase-dependent and -independent apoptosis in neuronal cells.
Title: Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis.
Phosphorylation of 4EBP1 is suppressed following treatment with everolimus in combination with radiation.
Title: Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway.
peptides that encompass the Raptor cross-linking region of 4E-BP1 inhibit cross-linking and interaction of 4E-BP1 with Raptor.
Title: Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.
Expression of 4E-BP1 isoforms varied among rat mammary carcinomas, their phosphorylation level being low in MNU-induced carcinomas, suggesting an association of mTOR activity with cancer etiology
Title: Aberrant expression and phosphorylation of 4E-BP1, a main target of mTOR signaling, in rat mammary carcinomas: an association with etiology.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables eukaryotic initiation factor 4E binding	IBA Inferred from Biological aspect of Ancestor more info
enables eukaryotic initiation factor 4E binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic initiation factor 4E binding	IPI Inferred from Physical Interaction more info	PubMed
enables eukaryotic initiation factor 4E binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info
enables translation repressor activity	ISO Inferred from Sequence Orthology more info
enables translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in IRES-dependent translational initiation of linear mRNA	IEA Inferred from Electronic Annotation more info
involved_in IRES-dependent translational initiation of linear mRNA	ISO Inferred from Sequence Orthology more info
involved_in TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to dexamethasone stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to dexamethasone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 4E-binding protein 1

Names: 4E-BP1; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053857.2 → NP_446309.1 eukaryotic translation initiation factor 4E-binding protein 1

See identical proteins and their annotated locations for NP_446309.1

Status: VALIDATED

Source sequence(s)

AI603218, U05014

UniProtKB/Swiss-Prot

Q62622

UniProtKB/TrEMBL

A0A8L2Q998

Related

ENSRNOP00000087155.1, ENSRNOT00000096679.1

Conserved Domains (1) summary

pfam05456
Location:1 → 117

eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)