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Dync1i2 dynein cytoplasmic 1 intermediate chain 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116659, updated on 13-Apr-2024

Summary

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Official Symbol
Dync1i2provided by RGD
Official Full Name
dynein cytoplasmic 1 intermediate chain 2provided by RGD
Primary source
RGD:620174
See related
Ensembl:ENSRNOG00000009781 AllianceGenome:RGD:620174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dnci2; Dncic2
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in brain development; cellular response to nerve growth factor stimulus; and negative regulation of neuron projection development. Located in cytoplasm. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 298.2), Lung (RPKM 269.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q22
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (76441621..76492782)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (56033882..56085080)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (57817677..57868854)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486105 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 28 Neighboring gene solute carrier family 25 member 12 Neighboring gene histone acetyltransferase 1 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Live cell imaging reveals differential modifications to cytoplasmic dynein properties by phospho- and dephosphomimic mutations of the intermediate chain 2C S84. Blasier KR, et al. J Neurosci Res, 2014 Sep. PMID 24798412, Free PMC Article
  2. Identification and developmental regulation of a neuron-specific subunit of cytoplasmic dynein. Pfister KK, et al. Mol Biol Cell, 1996 Feb. PMID 8688562, Free PMC Article
  3. Growth factor regulation of cytoplasmic dynein intermediate chain subunit expression preceding neurite extension. Salata MW, et al. J Neurosci Res, 2001 Sep 1. PMID 11536324
  4. Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. Vaughan KT, et al. J Cell Biol, 1995 Dec. PMID 8522607, Free PMC Article
  5. Integrated proteomics identified novel activation of dynein IC2-GR-COX-1 signaling in neurofibromatosis type I (NF1) disease model cells. Hirayama M, et al. Mol Cell Proteomics, 2013 May. PMID 23358504, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data of this study suggest that the IC-2C S84 has a role in modulating dynein properties.
    Title: Live cell imaging reveals differential modifications to cytoplasmic dynein properties by phospho- and dephosphomimic mutations of the intermediate chain 2C S84.
  2. Neurofibromatosis type I-related neural abnormalities are, in part, caused by up-regulation of dynein IC2-glucocorticoid receptor-COX-1 signaling.
    Title: Integrated proteomics identified novel activation of dynein IC2-GR-COX-1 signaling in neurofibromatosis type I (NF1) disease model cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93277

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to nerve growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in microtubule-based movement TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
part_of outer dynein arm ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytoplasmic dynein 1 intermediate chain 2
Names
DH IC-2
cytoplasmic dynein intermediate chain 2
dynein intermediate chain 2, cytosolic
dynein, cytoplasmic, intermediate chain 2
dynein, cytoplasmic, intermediate polypeptide 2
oncofetal protein (OFP)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270624.1 → NP_001257553.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001257553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC078764, CB733957, FM076575, FM110655, JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q62871, Q62872, Q62873
    UniProtKB/TrEMBL
    A6HM44, F7FJ03, Q6AZ35
    Related
    ENSRNOP00000042414.2, ENSRNOT00000047243.5
    Conserved Domains (4) summary
    COG2319
    Location:323 → 593
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:129 → 157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:333 → 371
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:270 → 592
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001270625.1 → NP_001257554.1  cytoplasmic dynein 1 intermediate chain 2 isoform 3

    See identical proteins and their annotated locations for NP_001257554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC078764, CB733957, FM076575, FM110655, JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q62871, Q62872, Q62873
    UniProtKB/TrEMBL
    A6HM45, D3ZU74
    Related
    ENSRNOP00000013400.4, ENSRNOT00000013400.7
    Conserved Domains (4) summary
    COG2319
    Location:303 → 573
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:109 → 137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:313 → 351
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:250 → 572
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_053880.2 → NP_446332.2  cytoplasmic dynein 1 intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_446332.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC078764, CB733957, FM076575, FM110655, JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q62871, Q62872, Q62873
    UniProtKB/TrEMBL
    A6HM43, G3V9V3
    Related
    ENSRNOP00000060919.3, ENSRNOT00000067729.5
    Conserved Domains (3) summary
    COG2319
    Location:329 → 599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339 → 377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135 → 163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    76441621..76492782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234346.5 → XP_006234408.1  cytoplasmic dynein 1 intermediate chain 2 isoform X6

    See identical proteins and their annotated locations for XP_006234408.1

    UniProtKB/Swiss-Prot
    Q62871, Q62872, Q62873
    UniProtKB/TrEMBL
    A6HM45, D3ZU74
    Conserved Domains (4) summary
    COG2319
    Location:303 → 573
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:109 → 137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:313 → 351
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:250 → 572
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_039104115.2 → XP_038960043.1  cytoplasmic dynein 1 intermediate chain 2 isoform X1

    UniProtKB/Swiss-Prot
    Q62871, Q62872, Q62873
    UniProtKB/TrEMBL
    A6HM43, G3V9V3
    Conserved Domains (3) summary
    COG2319
    Location:329 → 599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339 → 377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135 → 163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  3. XM_006234344.5 → XP_006234406.1  cytoplasmic dynein 1 intermediate chain 2 isoform X3

    See identical proteins and their annotated locations for XP_006234406.1

    UniProtKB/Swiss-Prot
    Q62871, Q62872, Q62873
    UniProtKB/TrEMBL
    A6HM44, F7FJ03, Q6AZ35
    Conserved Domains (4) summary
    COG2319
    Location:323 → 593
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:129 → 157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:333 → 371
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:270 → 592
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_063283006.1 → XP_063139076.1  cytoplasmic dynein 1 intermediate chain 2 isoform X4

  5. XM_063283007.1 → XP_063139077.1  cytoplasmic dynein 1 intermediate chain 2 isoform X7

  6. XM_063283000.1 → XP_063139070.1  cytoplasmic dynein 1 intermediate chain 2 isoform X2

  7. XM_017591432.3 → XP_017446921.1  cytoplasmic dynein 1 intermediate chain 2 isoform X1

    UniProtKB/Swiss-Prot
    Q62871, Q62872, Q62873
    UniProtKB/TrEMBL
    A6HM43, G3V9V3
    Conserved Domains (3) summary
    COG2319
    Location:329 → 599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339 → 377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135 → 163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  8. XM_063283003.1 → XP_063139073.1  cytoplasmic dynein 1 intermediate chain 2 isoform X5

  9. XM_063283001.1 → XP_063139071.1  cytoplasmic dynein 1 intermediate chain 2 isoform X3

    UniProtKB/TrEMBL
    A6HM44, F7FJ03, Q6AZ35

  10. XM_063283002.1 → XP_063139072.1  cytoplasmic dynein 1 intermediate chain 2 isoform X4

  11. XM_063283004.1 → XP_063139074.1  cytoplasmic dynein 1 intermediate chain 2 isoform X6

    UniProtKB/TrEMBL
    A6HM45, D3ZU74

  12. XM_063283005.1 → XP_063139075.1  cytoplasmic dynein 1 intermediate chain 2 isoform X7

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62871.1 GenPept UniProtKB/Swiss-Prot:Q62871

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