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Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 [ Mus musculus (house mouse) ]

Gene ID: 11668, updated on 18-Jan-2022

Summary

Official Symbol
Aldh1a1provided by MGI
Official Full Name
aldehyde dehydrogenase family 1, subfamily A1provided by MGI
Primary source
MGI:MGI:1353450
See related
Ensembl:ENSMUSG00000053279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E1; Ahd2; Ahd-2; Aldh1; ALHDII; Raldh1; ALDH-E1; Aldh1a2
Summary
Enables 3-chloroallyl aldehyde dehydrogenase activity and aminobutyraldehyde dehydrogenase activity. Involved in gamma-aminobutyric acid biosynthetic process and negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including optic cup morphogenesis involved in camera-type eye development; positive regulation of apoptotic process; and retinoid metabolic process. Located in axon and synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in liver adult (RPKM 141.6), genital fat pad adult (RPKM 125.0) and 12 other tissues See more
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Genomic context

See Aldh1a1 in Genome Data Viewer
Location:
19 B; 19 13.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (20469947..20620827)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (20492583..20643463)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (20676472..20717952)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32689 Neighboring gene predicted gene, 41816 Neighboring gene RIKEN cDNA E030003E18 gene Neighboring gene RIKEN cDNA C730002L08 gene Neighboring gene glutathione S-transferase kappa 1 Neighboring gene aldehyde dehydrogenase family 1, subfamily A7 Neighboring gene transmembrane channel-like gene family 1 Neighboring gene predicted gene, 32750

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in 9-cis-retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular detoxification of aldehyde ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic eye morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in fructosamine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in gamma-aminobutyric acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of lens transparency ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within optic cup morphogenesis involved in camera-type eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinoic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retinoic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within retinoic acid metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within retinoic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retinol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aldehyde dehydrogenase 1A1
Names
3-deoxyglucosone dehydrogenase
RALDH 1
alcohol dehydrogenase family 1, subfamily A1
alcohol dehydrogenase family 1, subfamily A2
aldehyde dehydrogenase 1, liver cytosolic (class 1)
aldehyde dehydrogenase family 1 member A1
aldehyde dehydrogenase, cytosolic
retinal dehydrogenase 1
NP_001348432.1
NP_001348433.1
NP_001348434.1
NP_001348435.1
NP_038495.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361503.1NP_001348432.1  aldehyde dehydrogenase 1A1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AC152162, AC167167
    Consensus CDS
    CCDS29695.1
    Conserved Domains (1) summary
    cd07141
    Location:15495
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
  2. NM_001361504.1NP_001348433.1  aldehyde dehydrogenase 1A1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC152162, AC167167
    Consensus CDS
    CCDS29695.1
    Conserved Domains (1) summary
    cd07141
    Location:15495
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
  3. NM_001361505.1NP_001348434.1  aldehyde dehydrogenase 1A1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC152162, AC167167
    Consensus CDS
    CCDS29695.1
    Conserved Domains (1) summary
    cd07141
    Location:15495
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
  4. NM_001361506.1NP_001348435.1  aldehyde dehydrogenase 1A1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC152162, AC167167
    Consensus CDS
    CCDS29695.1
    Related
    ENSMUSP00000153410.3, ENSMUST00000225337.3
    Conserved Domains (1) summary
    cd07141
    Location:15495
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
  5. NM_013467.4NP_038495.2  aldehyde dehydrogenase 1A1

    See identical proteins and their annotated locations for NP_038495.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC152162, AC167167
    Consensus CDS
    CCDS29695.1
    UniProtKB/Swiss-Prot
    P24549
    Related
    ENSMUSP00000084918.4, ENSMUST00000087638.4
    Conserved Domains (1) summary
    cd07141
    Location:15495
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    20469947..20620827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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