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Pabpn1 poly(A) binding protein, nuclear 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116697, updated on 13-Apr-2024

Summary

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Official Symbol
Pabpn1provided by RGD
Official Full Name
poly(A) binding protein, nuclear 1provided by RGD
Primary source
RGD:619928
See related
Ensembl:ENSRNOG00000042195 AllianceGenome:RGD:619928
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase binding activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; poly(A)+ mRNA export from nucleus; and positive regulation of polynucleotide adenylyltransferase activity. Located in nuclear inclusion body. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 80.0), Testes (RPKM 78.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pabpn1 in Genome Data Viewer
Location:
15p13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32337955..32342700)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28368100..28372712)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33555640..33560251)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene Bcl2-like 2 Neighboring gene solute carrier family 22, member 17 Neighboring gene embryonal Fyn-associated substrate

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear compartmentalization and dynamics of the poly(A)-binding protein nuclear 1 (PABPN1) inclusions in supraoptic neurons under physiological and osmotic stress conditions. Villagra NT, et al. Mol Cell Neurosci, 2008 Mar. PMID 18255312
  2. Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene. Matsubara S, et al. Neuromuscul Disord, 2016 Jul. PMID 27209344
  3. Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus. Berciano MT, et al. Hum Mol Genet, 2004 Apr 15. PMID 14976164
  4. Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells. Zhang L, et al. J Cell Mol Med, 2022 Sep. PMID 35894779, Free PMC Article
  5. Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1. Su YL, et al. PLoS One, 2012. PMID 22844456, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells.
    Title: Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in poly(A)+ mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear inclusion body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inclusion body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polyadenylate-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135008.1 → NP_001128480.1  polyadenylate-binding protein 2

    See identical proteins and their annotated locations for NP_001128480.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6KGX0, G3V7Z8
    Related
    ENSRNOP00000021096.3, ENSRNOT00000021096.7
    Conserved Domains (2) summary
    COG0724
    Location:109 → 285
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12550
    Location:169 → 244
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    32337955..32342700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273914.1 → XP_063129984.1  polyadenylate-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5F1
Nucleotide Protein Strain
Heading Accession and Version

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