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Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 [ Mus musculus (house mouse) ]

Gene ID: 11670, updated on 21-Apr-2024

Summary

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Official Symbol
Aldh3a1provided by MGI
Official Full Name
aldehyde dehydrogenase family 3, subfamily A1provided by MGI
Primary source
MGI:MGI:1353451
See related
Ensembl:ENSMUSG00000019102 AllianceGenome:MGI:1353451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ahd4; Aldh; Ahd-4; Aldh3
Summary
Enables 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytoplasm. Is integral component of membrane. Is expressed in several structures, including alimentary system; decidua; early conceptus; gonad; and liver. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 55.3), stomach adult (RPKM 53.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
11 B2; 11 37.96 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61099336..61109244)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61208510..61218418)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42080 Neighboring gene ribosomal protein S13, pseudogene 5 Neighboring gene aldehyde dehydrogenase family 3, subfamily A2 Neighboring gene STARR-positive B cell enhancer ABC_E6993 Neighboring gene STARR-seq mESC enhancer starr_29673 Neighboring gene STARR-seq mESC enhancer starr_29674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61123776-61123977 Neighboring gene solute carrier family 47, member 2 Neighboring gene predicted gene, 25929

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Contribution of Alcohol Dehydrogenase 3 to the Development of Alcoholic Osteoporosis in Mice. Okuda T, et al. J Nippon Med Sch, 2018. PMID 30568058
  2. Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. Saiki JP, et al. Proc Natl Acad Sci U S A, 2018 Jun 12. PMID 29794221, Free PMC Article
  3. Corneal haze phenotype in Aldh3a1-null mice: In vivo confocal microscopy and tissue imaging mass spectrometry. Chen Y, et al. Chem Biol Interact, 2017 Oct 1. PMID 28038895
  4. Varying levels of aldehyde dehydrogenase activity in adult murine marrow hematopoietic stem cells are associated with engraftment and cell cycle status. Gasparetto M, et al. Exp Hematol, 2012 Oct. PMID 22683567
  5. Endogenous acetaldehyde toxicity during antral follicular development in the mouse ovary. Kawai T, et al. Reprod Toxicol, 2012 Jun. PMID 22285649, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Generation and characterization of Aldh3-Cre transgenic mice as a tool for conditional gene deletion in postnatal cornea.
    Title: Generation and characterization of Aldh3-Cre transgenic mice as a tool for conditional gene deletion in postnatal cornea.
  2. This study found that oncogene-transformed embryonic fibroblasts prepared from Per2-mutant (Per2(m/m) ) mice, which are susceptible to both spontaneous and radiation-induced tumorigenesis, were resistant against common chemotherapeutic drugs and that this resistance is associated with up-regulation of the aldehyde dehydrogenase 3a1 (Aldh3a1) gene.
    Title: Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene.
  3. The alcohol dehydrogenase 3 (ADH3-/-) control mice exhibited increased activities of both osteoblasts and osteoclasts and lower bone masses than the WT control mice.
    Title: The Contribution of Alcohol Dehydrogenase 3 to the Development of Alcoholic Osteoporosis in Mice.
  4. It is responsible for systemic alcohol metabolism.
    Title: Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in mice.
  5. ALDH3A1 activation by d-limonene significantly reduced aldehyde accumulation in SSPCs.
    Title: Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.
  6. The corneal phenotype of Aldh3a1 showed no differences were observed in lipid profiles from knockout relative to wild type mice; however, changes in protein profiles of acyl-CoA binding protein (m/z 9966) and histone H4.4 (m/z 11308) were found to be increased in the corneal epithelial layer of knockout mice.
    Title: Corneal haze phenotype in Aldh3a1-null mice: In vivo confocal microscopy and tissue imaging mass spectrometry.
  7. ALDH3A1 has a role in the maintenance of corneal epithelial homeostasis by simultaneously modulating proliferation and differentiation through both enzymatic and non-enzymatic mechanisms
    Title: ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis.
  8. ADH3 protects liver from steatosis by supporting normal lipid metabolism and prevents progression of steatosis into steatohepatitis by maintaining the cellular glutathione level.
    Title: Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.
  9. focused on ALDH3A1, which is enriched in the upper aerodigestive track, and identified Alda-89 as a small molecule that enables ALDH3A1 to metabolize acetaldehyde
    Title: Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.
  10. Varying levels of aldehyde dehydrogenase activity in adult murine marrow hematopoietic stem cells are associated with engraftment and cell cycle status.
    Title: Varying levels of aldehyde dehydrogenase activity in adult murine marrow hematopoietic stem cells are associated with engraftment and cell cycle status.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-chloroallyl aldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-chloroallyl aldehyde dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 3-chloroallyl aldehyde dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables alcohol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables aldehyde dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables benzaldehyde dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular aldehyde metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular aldehyde metabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in cellular aldehyde metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
  
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aldehyde dehydrogenase, dimeric NADP-preferring
Names
alcohol dehydrogenase family 3, subfamily A1
aldehyde dehydrogenase 3, stomach cytosolic (class 3)
aldehyde dehydrogenase 4
aldehyde dehydrogenase family 3 member A1
dioxin-inducible aldehyde dehydrogenase 3
NP_001106196.1
NP_001318041.1
NP_031462.2
XP_006532086.1
XP_006532087.1
XP_006532089.1
XP_006532090.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112725.1 → NP_001106196.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform 1

    See identical proteins and their annotated locations for NP_001106196.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 3. The encoded isoform (1) is shorter than isoform 2. Both variants 1 and 2 encode the same isoform (2).
    Source sequence(s)
    AK144241, EL957097, EL959139, EL959277, EL961165, EL963960
    Consensus CDS
    CCDS24808.1
    UniProtKB/Swiss-Prot
    B1ATI7, P47739, Q9R203
    UniProtKB/TrEMBL
    Q3UNF5
    Related
    ENSMUSP00000104356.2, ENSMUST00000108716.8
    Conserved Domains (1) summary
    cd07132
    Location:5 → 447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  2. NM_001331112.1 → NP_001318041.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2).
    Source sequence(s)
    AL646093, CX734286
    UniProtKB/TrEMBL
    B7ZN13
    Conserved Domains (1) summary
    cd07132
    Location:5 → 447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  3. NM_007436.2 → NP_031462.2  aldehyde dehydrogenase, dimeric NADP-preferring isoform 1

    See identical proteins and their annotated locations for NP_031462.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region compared to variant 3. The encoded isoform (1) is shorter than isoform 2. Both variants 1 and 2 encode the same isoform (2).
    Source sequence(s)
    AK144241, AL646093, EL957097, EL959139, EL959277, EL961165, EL963960
    Consensus CDS
    CCDS24808.1
    UniProtKB/Swiss-Prot
    B1ATI7, P47739, Q9R203
    UniProtKB/TrEMBL
    Q3UNF5
    Related
    ENSMUSP00000019246.4, ENSMUST00000019246.4
    Conserved Domains (1) summary
    cd07132
    Location:5 → 447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61099336..61109244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532024.3 → XP_006532087.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X1

    See identical proteins and their annotated locations for XP_006532087.1

    UniProtKB/TrEMBL
    B7ZN13
    Conserved Domains (1) summary
    cd07132
    Location:5 → 447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  2. XM_006532027.4 → XP_006532090.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X2

    See identical proteins and their annotated locations for XP_006532090.1

    UniProtKB/Swiss-Prot
    B1ATI7, P47739, Q9R203
    UniProtKB/TrEMBL
    Q3UNF5
    Conserved Domains (1) summary
    cd07132
    Location:5 → 447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  3. XM_006532023.1 → XP_006532086.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X1

    See identical proteins and their annotated locations for XP_006532086.1

    UniProtKB/TrEMBL
    B7ZN13
    Conserved Domains (1) summary
    cd07132
    Location:5 → 447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  4. XM_006532026.1 → XP_006532089.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X2

    See identical proteins and their annotated locations for XP_006532089.1

    UniProtKB/Swiss-Prot
    B1ATI7, P47739, Q9R203
    UniProtKB/TrEMBL
    Q3UNF5
    Conserved Domains (1) summary
    cd07132
    Location:5 → 447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47739.2 GenPept UniProtKB/Swiss-Prot:P47739

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