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Aldoc aldolase C, fructose-bisphosphate [ Mus musculus (house mouse) ]

Gene ID: 11676, updated on 5-Sep-2021

Summary

Official Symbol
Aldocprovided by MGI
Official Full Name
aldolase C, fructose-bisphosphateprovided by MGI
Primary source
MGI:MGI:101863
See related
Ensembl:ENSMUSG00000017390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Al; Scr; Aldo3; Scrg2; AI847350; AU040929
Summary
This gene encodes a member of the aldolase family of enzymes that is mainly expressed in neuronal tissues. The encoded protein is an enzyme of the glycolysis pathway, and catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Biased expression in cerebellum adult (RPKM 424.1), cortex adult (RPKM 249.9) and 4 other tissues See more
Orthologs
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Genomic context

See Aldoc in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78213899..78218607)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78323073..78327781)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (78137700..78140262)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase related Neighboring gene predicted gene 3948 Neighboring gene sperm associated antigen 5 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class S Neighboring gene unc-119 lipid binding chaperone

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables fructose-bisphosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructose-bisphosphate aldolase activity ISO
Inferred from Sequence Orthology
more info
 
enables fructose-bisphosphate aldolase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fructose 1,6-bisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
fructose-bisphosphate aldolase C
Names
brain-type aldolase
scrapie responsive gene 2
scrapie-responsive protein 2
zebrin II
NP_001290352.1
NP_033787.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303423.1NP_001290352.1  fructose-bisphosphate aldolase C

    See identical proteins and their annotated locations for NP_001290352.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL591070
    Consensus CDS
    CCDS25099.1
    UniProtKB/Swiss-Prot
    P05063
    Related
    ENSMUSP00000017534.9, ENSMUST00000017534.15
    Conserved Domains (1) summary
    pfam00274
    Location:15363
    Glycolytic; Fructose-bisphosphate aldolase class-I
  2. NM_009657.4NP_033787.2  fructose-bisphosphate aldolase C

    See identical proteins and their annotated locations for NP_033787.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL591070
    Consensus CDS
    CCDS25099.1
    UniProtKB/Swiss-Prot
    P05063
    Related
    ENSMUSP00000099536.4, ENSMUST00000102478.4
    Conserved Domains (1) summary
    pfam00274
    Location:15363
    Glycolytic; Fructose-bisphosphate aldolase class-I

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78213899..78218607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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