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Baz2a bromodomain adjacent to zinc finger domain, 2A [ Mus musculus (house mouse) ]

Gene ID: 116848, updated on 11-Apr-2024

Summary

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Official Symbol
Baz2aprovided by MGI
Official Full Name
bromodomain adjacent to zinc finger domain, 2Aprovided by MGI
Primary source
MGI:MGI:2151152
See related
Ensembl:ENSMUSG00000040054 AllianceGenome:MGI:2151152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tip5; Walp3; mKIAA0314; C030005G16Rik
Summary
Enables DNA binding activity; RNA binding activity; and lysine-acetylated histone binding activity. Involved in DNA methylation; histone deacetylation; and negative regulation of macromolecule metabolic process. Acts upstream of or within chromatin organization and histone modification. Located in nucleolus and rDNA heterochromatin. Part of chromatin silencing complex. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and paraxial mesenchyme. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 35.9), testis adult (RPKM 35.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Baz2a in Genome Data Viewer
Location:
10 D3; 10 76.4 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127927453..127965172)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128091370..128129303)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase F1 subunit beta Neighboring gene STARR-positive B cell enhancer ABC_E8377 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127529132-127529333 Neighboring gene STARR-positive B cell enhancer ABC_E8993 Neighboring gene microRNA 677 Neighboring gene STARR-seq mESC enhancer starr_28259 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127534859-127535012 Neighboring gene STARR-seq mESC enhancer starr_28261 Neighboring gene predicted gene, 51821 Neighboring gene RNA binding motif, single stranded interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E11466 Neighboring gene STARR-seq mESC enhancer starr_28269 Neighboring gene predicted gene 4556

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BAZ2A safeguards genome architecture of ground-state pluripotent stem cells. Dalcher D, et al. EMBO J, 2020 Dec 1. PMID 33433018, Free PMC Article
  2. CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5. Ling T, et al. Biochem Biophys Res Commun, 2013 Jul 19. PMID 23796711
  3. The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus. Mayer C, et al. EMBO Rep, 2008 Aug. PMID 18600236, Free PMC Article
  4. TIP5 primes prostate luminal cells for the oncogenic transformation mediated by PTEN-loss. Pietrzak K, et al. Proc Natl Acad Sci U S A, 2020 Feb 18. PMID 32024754, Free PMC Article
  5. The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Santoro R, et al. Nat Genet, 2002 Nov. PMID 12368916

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration.
    Title: In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration.
  2. BAZ2A safeguards genome architecture of ground-state pluripotent stem cells.
    Title: BAZ2A safeguards genome architecture of ground-state pluripotent stem cells.
  3. TIP5 is critical for the initiation of prostate cancer of luminal origin mediated by Pten-loss whereas it is dispensable once Pten-loss mediated transformation is established.
    Title: TIP5 primes prostate luminal cells for the oncogenic transformation mediated by PTEN-loss.
  4. NuRD negatively regulates TIP5 expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.
    Title: CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5.
  5. Tip5 not only mediates the establishment of rDNA silencing but also the formation of perinucleolar heterochromatin that contains centric and pericentric repeats.
    Title: The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats.
  6. Data show that MOF acetylates TIP5, the largest subunit of NoRC, at a single lysine residue, K633, adjacent to the TIP5 RNA-binding domain, and that SIRT1 (removes the acetyl group from K633.
    Title: Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing.
  7. Mutations that disrupt the stem-loop structure impair binding of TIP5, the large subunit of NoRC, to pRNA and abolish targeting of NoRC to nucleoli.
    Title: The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus.
  8. Overexpression of TIP5, the large subunit of NoRC, mediates deacetylation of nucleosomes near the rDNA promoter. TIP5 associates with HDAC1 in vivo & in vitro. Deletion of the C-terminal PHD finger & bromodomain abolishes the interaction of TIP5 & HDAC1.
    Title: The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription.
  9. The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.
    Title: The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (6) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase I core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin-protein adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rDNA heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rDNA heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NoRC complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of chromatin silencing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of rDNA heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bromodomain adjacent to zinc finger domain protein 2A
Names
TTF-I-interacting protein 5
transcription termination factor I-interacting protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054078.2 → NP_473419.2  bromodomain adjacent to zinc finger domain protein 2A

    See identical proteins and their annotated locations for NP_473419.2

    Status: VALIDATED

    Source sequence(s)
    AC131120, AC166817
    Consensus CDS
    CCDS36088.1
    UniProtKB/TrEMBL
    A0A5F8MPQ7, F8VPM0
    Related
    ENSMUSP00000044359.9, ENSMUST00000045621.9
    Conserved Domains (8) summary
    cd05503
    Location:1780 → 1876
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:839 → 901
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 516
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:407 → 533
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:541 → 613
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1662 → 1708
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1150 → 1420
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1423 → 1457
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127927453..127965172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243278.4 → XP_011241580.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

    See identical proteins and their annotated locations for XP_011241580.1

    UniProtKB/TrEMBL
    A0A1W2P6X9, E9Q374
    Conserved Domains (8) summary
    cd05503
    Location:1781 → 1877
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:840 → 902
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 517
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:408 → 534
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:542 → 614
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1663 → 1709
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1151 → 1421
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1424 → 1458
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  2. XM_030244833.2 → XP_030100693.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    UniProtKB/TrEMBL
    A0A5F8MPQ7, F8VPM0
    Conserved Domains (8) summary
    cd05503
    Location:1780 → 1876
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:839 → 901
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 516
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:407 → 533
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:541 → 613
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1662 → 1708
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1150 → 1420
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1423 → 1457
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  3. XM_011243283.4 → XP_011241585.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

    See identical proteins and their annotated locations for XP_011241585.1

    UniProtKB/TrEMBL
    A0A1W2P6X9, E9Q374
    Conserved Domains (8) summary
    cd05503
    Location:1781 → 1877
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:840 → 902
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 517
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:408 → 534
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:542 → 614
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1663 → 1709
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1151 → 1421
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1424 → 1458
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  4. XM_011243285.4 → XP_011241587.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    See identical proteins and their annotated locations for XP_011241587.1

    UniProtKB/TrEMBL
    A0A5F8MPQ7, F8VPM0
    Conserved Domains (8) summary
    cd05503
    Location:1780 → 1876
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:839 → 901
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 516
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:407 → 533
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:541 → 613
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1662 → 1708
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1150 → 1420
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1423 → 1457
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  5. XM_036155519.1 → XP_036011412.1  bromodomain adjacent to zinc finger domain protein 2A isoform X4

    UniProtKB/TrEMBL
    A0A5F8MPQ7

  6. XM_011243280.4 → XP_011241582.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

    See identical proteins and their annotated locations for XP_011241582.1

    UniProtKB/TrEMBL
    A0A1W2P6X9, E9Q374
    Conserved Domains (8) summary
    cd05503
    Location:1781 → 1877
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:840 → 902
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 517
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:408 → 534
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:542 → 614
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1663 → 1709
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1151 → 1421
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1424 → 1458
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  7. XM_030244832.2 → XP_030100692.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

    UniProtKB/TrEMBL
    A0A1W2P6X9, E9Q374
    Conserved Domains (8) summary
    cd05503
    Location:1781 → 1877
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:840 → 902
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 517
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:408 → 534
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:542 → 614
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1663 → 1709
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1151 → 1421
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1424 → 1458
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  8. XM_011243282.4 → XP_011241584.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

    See identical proteins and their annotated locations for XP_011241584.1

    UniProtKB/TrEMBL
    A0A1W2P6X9, E9Q374
    Conserved Domains (8) summary
    cd05503
    Location:1781 → 1877
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:840 → 902
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 517
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:408 → 534
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:542 → 614
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1663 → 1709
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1151 → 1421
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1424 → 1458
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  9. XM_030244830.1 → XP_030100690.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

    UniProtKB/TrEMBL
    A0A1W2P6X9, E9Q374
    Conserved Domains (8) summary
    cd05503
    Location:1781 → 1877
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:840 → 902
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 517
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:408 → 534
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:542 → 614
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1663 → 1709
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1151 → 1421
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1424 → 1458
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  10. XM_006513115.4 → XP_006513178.1  bromodomain adjacent to zinc finger domain protein 2A isoform X3

    UniProtKB/TrEMBL
    A0A1W2P6X9
    Conserved Domains (8) summary
    cd05503
    Location:1780 → 1876
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:840 → 902
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 517
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:408 → 534
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:542 → 614
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1663 → 1709
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1151 → 1421
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1424 → 1458
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  11. XM_006513114.4 → XP_006513177.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    See identical proteins and their annotated locations for XP_006513177.1

    UniProtKB/TrEMBL
    A0A5F8MPQ7, F8VPM0
    Conserved Domains (8) summary
    cd05503
    Location:1780 → 1876
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:839 → 901
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 516
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:407 → 533
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:541 → 613
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1662 → 1708
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1150 → 1420
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1423 → 1457
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  12. XM_011243284.4 → XP_011241586.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

    See identical proteins and their annotated locations for XP_011241586.1

    UniProtKB/TrEMBL
    A0A1W2P6X9, E9Q374
    Related
    ENSMUSP00000151445.2, ENSMUST00000217851.2
    Conserved Domains (8) summary
    cd05503
    Location:1781 → 1877
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:840 → 902
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 517
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:408 → 534
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:542 → 614
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1663 → 1709
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1151 → 1421
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1424 → 1458
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  13. XM_011243286.4 → XP_011241588.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    See identical proteins and their annotated locations for XP_011241588.1

    UniProtKB/TrEMBL
    A0A5F8MPQ7, F8VPM0
    Related
    ENSMUSP00000151961.2, ENSMUST00000220049.2
    Conserved Domains (8) summary
    cd05503
    Location:1780 → 1876
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:839 → 901
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 516
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:407 → 533
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:541 → 613
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1662 → 1708
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1150 → 1420
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1423 → 1457
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  14. XM_030244835.2 → XP_030100695.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    UniProtKB/TrEMBL
    A0A5F8MPQ7, F8VPM0
    Conserved Domains (8) summary
    cd05503
    Location:1780 → 1876
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:839 → 901
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 516
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:407 → 533
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:541 → 613
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1662 → 1708
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1150 → 1420
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1423 → 1457
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  15. XM_030244831.2 → XP_030100691.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

    UniProtKB/TrEMBL
    A0A1W2P6X9, E9Q374
    Related
    ENSMUSP00000129803.3, ENSMUST00000170054.9
    Conserved Domains (8) summary
    cd05503
    Location:1781 → 1877
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:840 → 902
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 517
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:408 → 534
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:542 → 614
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1663 → 1709
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1151 → 1421
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1424 → 1458
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  16. XM_030244834.2 → XP_030100694.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    UniProtKB/TrEMBL
    A0A5F8MPQ7, F8VPM0
    Conserved Domains (8) summary
    cd05503
    Location:1780 → 1876
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:839 → 901
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03307
    Location:269 → 516
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:407 → 533
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01397
    Location:541 → 613
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1662 → 1708
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:1150 → 1420
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:1423 → 1457
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  17. XM_011243287.4 → XP_011241589.1  bromodomain adjacent to zinc finger domain protein 2A isoform X5

    Conserved Domains (6) summary
    cd05503
    Location:1240 → 1336
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:299 → 361
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:10 → 73
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:1122 → 1168
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam03154
    Location:610 → 880
    Atrophin-1; Atrophin-1 family
    pfam15613
    Location:883 → 917
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YE5.2 GenPept UniProtKB/Swiss-Prot:Q91YE5

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