Alox12e arachidonate lipoxygenase, epidermal [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alox12eprovided by MGI
Official Full Name: arachidonate lipoxygenase, epidermalprovided by MGI
Primary source: MGI:MGI:1274790
See related: Ensembl:ENSMUSG00000018907 AllianceGenome:MGI:1274790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 8-LOX; Aloxe; 12-LOX; e-LOX1; 12-LOX-e; Alox12-ps1; Alox12-ps2
Summary: Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in arachidonic acid metabolic process and lipoxygenase pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol and plasma membrane. Is expressed in alimentary system; hemolymphoid system; integumental system; and respiratory system. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 12.1), ovary adult (RPKM 7.2) and 3 other tissues See more
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Genomic context

Location:: 11 B3; 11 42.99 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70206436..70213545, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70315610..70322720, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Senescence-associated tumor growth is promoted by 12-Lipoxygenase.
Title: Senescence-associated tumor growth is promoted by 12-Lipoxygenase.
12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
Title: 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
these results suggest that the MaR1/RORalpha/12-LOX autoregulatory circuit could offer potential therapeutic strategies for curing NASH.
Title: A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis.
identification and characterization of a phorbol ester-responsive element
Title: Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

General gene information

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Markers

AW259591 (e-PCR)
- UniSTS:180239

NoName (e-PCR)
- UniSTS:236624

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonate 12(S)-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate 12(S)-lipoxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables arachidonate 15-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables linoleate 13S-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables linoleate 13S-lipoxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonic acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoxygenase pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoxygenase pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type

Names: arachidonate (12S)-lipoxygenase, epidermal-type; arachidonate 12-lipoxygenase, epidermal; arachidonate 12-lipoxygenase, epidermal-type; e(12S)-LOX; linoleate (13S)-lipoxygenase

NP_663717.1

EC 1.13.11.31

XP_006532097.1

EC 1.13.11.31

XP_006532098.1

EC 1.13.11.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145684.2 → NP_663717.1 polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type

See identical proteins and their annotated locations for NP_663717.1

Status: VALIDATED

Source sequence(s)

AK138743, AL596096, BX630350

Consensus CDS

CCDS24943.1

UniProtKB/Swiss-Prot

P55249, Q91YW6

UniProtKB/TrEMBL

Q5F2E4

Related

ENSMUSP00000019051.3, ENSMUST00000019051.3

Conserved Domains (2) summary

cd01753
Location:2 → 111

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:169 → 653

Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

70206436..70213545 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532035.4 → XP_006532098.1 polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type isoform X2

See identical proteins and their annotated locations for XP_006532098.1

Conserved Domains (2) summary

cd01753
Location:35 → 143

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:193 → 685

Lipoxygenase
XM_006532034.5 → XP_006532097.1 polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type isoform X1

See identical proteins and their annotated locations for XP_006532097.1

Conserved Domains (2) summary

cd01753
Location:35 → 144

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:194 → 686

Lipoxygenase