Serpinb7 serine (or cysteine) peptidase inhibitor, clade B, member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb7provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B, member 7provided by MGI
Primary source: MGI:MGI:2151053
See related: Ensembl:ENSMUSG00000067001 AllianceGenome:MGI:2151053
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: megsin; ovalbumin; 4631416M05Rik
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including positive regulation of collagen biosynthetic process; positive regulation of cytokine production; and positive regulation of glomerular mesangial cell proliferation. Predicted to act upstream of or within regulation of proteolysis. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINB7 (serpin family B member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 E2.1; 1 50.34 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (107350418..107380419)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (107422689..107452689)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in systemic inflammatory response syndrome (SIRS), SERPINB7 showed no difference in expression in immuneactivated tissues from systemic inflammatory response syndrome and control mice.
Title: Systematic screening and identification of novel psoriasis‑specific genes from the transcriptome of psoriasis‑like keratinocytes.
Suggest that the down-regulation of megsin might exert beneficial effects on the diabetic kidney partly through down-regulation of p27(kip1).
Title: Delivery of megsin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by down-regulating p27(kip1) level.
diabetic nephropathy model in triple transgenic mice overexpressing RAGE, iNOS & megsin; triple-hit damage develops severe diabetic nephropathy at early age with mesangial expansion, nodule-like lesion & tubulointerstitial damage with oxidative stress
Title: A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet-derived growth factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta1 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of proteolysis	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serpin B7

Names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7; serine (or cysteine) proteinase inhibitor, clade B, member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027548.4 → NP_081824.1 serpin B7

See identical proteins and their annotated locations for NP_081824.1

Status: VALIDATED

Source sequence(s)

AC129295, AC148982

Consensus CDS

CCDS35686.1

UniProtKB/Swiss-Prot

Q9D695

UniProtKB/TrEMBL

Q6P3F8

Related

ENSMUSP00000083896.5, ENSMUST00000086690.6

Conserved Domains (1) summary

cl00137
Location:4 → 380

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...