Gfer growth factor, augmenter of liver regeneration [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gferprovided by MGI
Official Full Name: growth factor, augmenter of liver regenerationprovided by MGI
Primary source: MGI:MGI:107757
See related: Ensembl:ENSMUSG00000040888 AllianceGenome:MGI:107757
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Alr; ERV1
Summary: Predicted to enable flavin adenine dinucleotide binding activity and flavin-linked sulfhydryl oxidase activity. Predicted to be involved in several processes, including liver regeneration; negative regulation of cell death; and negative regulation of natural killer cell mediated cytotoxicity. Located in mitochondrion. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 40.9), colon adult (RPKM 27.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.48 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24912164..24915065, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24693190..24696156, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment.
Title: TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment.
Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma.
Title: Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma.
Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8.
Title: Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8.
Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis.
Title: Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis.
In gain-of-function studies using mice overexpressing the human resolvin E1 receptor (ERV1) in myeloid cells, monocyte phenotypic shifts to increased patrolling-to-inflammatory ratio controlled inflammation, reduced body weight gain and protected from hyperglycemia on high-fat diet.
Title: ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance.
Study in mouse model of liver cirrhosis demonstrate that the lack of ALR aggravates liver fibrosis, probably by regulating mitochondrial Ca2+ homeostasis and mitochondrial dynamics in hepatic stellate cells.
Title: Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell.
To test whether differences in the ratio between CHCHD4 and ALR might explain tissue-specific differences in the CHCHD4 redox state, we determined the molar ratio of both proteins in different mouse tissues. Surprisingly, ALR is superstoichiometric over CHCHD4 in most tissues.
Title: The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo.
role in regulating the mitochondrial fission machinery
Title: Hepatic stimulator substance resists hepatic ischemia/reperfusion injury by regulating Drp1 translocation and activation.
The exogenous expression of hepatic stimulator substance (HSS was renamed augmenter of liver regeneration ALR) protected the liver from steatosis in mice with nonalcoholic steatohepatitis.
Title: Hepatic stimulator substance inhibits calcium overflow through the mitochondria-associated membrane compartment during nonalcoholic steatohepatitis.
this study shows that ALR can weaken ConA-induced hepatitis
Title: Augmenter of liver regeneration (ALR) restrains concanavalin A-induced hepatitis in mice.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	ISO Inferred from Sequence Orthology more info
enables flavin-dependent sulfhydryl oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin-dependent sulfhydryl oxidase activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info
enables thiol oxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in liver development	IBA Inferred from Biological aspect of Ancestor more info
involved_in liver regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: FAD-linked sulfhydryl oxidase ALR

Names: augmenter of liver regeneration; growth factor, erv1-like (augmenter of liver regeneration)

NP_001365967.1

EC 1.8.3.2

NP_001365968.1

EC 1.8.3.2

NP_001396906.1

EC 1.8.3.2

NP_001396910.1

EC 1.8.3.2

NP_075527.2

EC 1.8.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379038.1 → NP_001365967.1 FAD-linked sulfhydryl oxidase ALR isoform 2

Status: VALIDATED

Source sequence(s)

AC154566, CJ043716

UniProtKB/TrEMBL

A0A3Q4EGL6

Related

ENSMUSP00000157249.2, ENSMUST00000234235.2

Conserved Domains (1) summary

pfam04777
Location:87 → 177

Evr1_Alr; Erv1 / Alr family
NM_001379039.1 → NP_001365968.1 FAD-linked sulfhydryl oxidase ALR isoform 3

Status: VALIDATED

Source sequence(s)

AC154566

Conserved Domains (1) summary

cl02107
Location:79 → 144

Evr1_Alr; Erv1 / Alr family
NM_001409977.1 → NP_001396906.1 FAD-linked sulfhydryl oxidase ALR 4

Status: VALIDATED

Source sequence(s)

AC154566
NM_001409981.1 → NP_001396910.1 FAD-linked sulfhydryl oxidase ALR 5

Status: VALIDATED

Source sequence(s)

AC154566
NM_023040.4 → NP_075527.2 FAD-linked sulfhydryl oxidase ALR isoform 1

See identical proteins and their annotated locations for NP_075527.2

Status: VALIDATED

Source sequence(s)

AC154566

Consensus CDS

CCDS28492.1

UniProtKB/Swiss-Prot

P56213, Q8CIF8, Q9JJE6

Related

ENSMUSP00000049186.9, ENSMUST00000046839.10

Conserved Domains (1) summary

cl02107
Location:79 → 194

Evr1_Alr; Erv1 / Alr family

RNA

NR_176925.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154566
NR_176926.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154566

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

24912164..24915065 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_212443.1: Suppressed sequence

Description

NM_212443.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.