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Mmp12 matrix metallopeptidase 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117033, updated on 6-May-2021

Summary

Official Symbol
Mmp12provided by RGD
Official Full Name
matrix metallopeptidase 12provided by RGD
Primary source
RGD:620195
See related
Ensembl:ENSRNOG00000030187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mme
Summary
a macrophage metalloelastase/matrix metalloproteinase; may have a role in glomerular injury in a crescentic glomerulonephritis [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 140.7), Spleen (RPKM 50.9) and 5 other tissues See more
Orthologs
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Genomic context

See Mmp12 in Genome Data Viewer
Location:
8q11
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (4581785..4591687)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (5594717..5616494)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 13 Neighboring gene similar to Aspartyl-tRNA synthetase (Aspartate--tRNA ligase) (AspRS) Neighboring gene matrix metallopeptidase 1b (interstitial collagenase) Neighboring gene matrix metallopeptidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding IEA
Inferred from Electronic Annotation
more info
 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bronchiole development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bronchiole development ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in elastin catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in elastin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell-matrix adhesion via fibronectin IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell-matrix adhesion via fibronectin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation involved in wound healing IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epithelial cell proliferation involved in wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-alpha production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of defense response to virus by host IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of trophoblast cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in wound healing, spreading of epidermal cells IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
macrophage metalloelastase
Names
MMP-12
matrix metalloproteinase-12
NP_446415.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053963.2NP_446415.2  macrophage metalloelastase preproprotein

    See identical proteins and their annotated locations for NP_446415.2

    Status: VALIDATED

    Source sequence(s)
    BC088120, CB791502
    UniProtKB/Swiss-Prot
    Q63341
    UniProtKB/TrEMBL
    R9PXT7
    Related
    ENSRNOP00000011727.6, ENSRNOT00000011727.6
    Conserved Domains (4) summary
    cd00094
    Location:293477
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:116271
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:116271
    Peptidase_M10; Matrixin
    pfam01471
    Location:4195
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    4581785..4591687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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