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Cts3 cathepsin 3 [ Mus musculus (house mouse) ]

Gene ID: 117066, updated on 8-Feb-2024

Summary

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Official Symbol
Cts3provided by MGI
Official Full Name
cathepsin 3provided by MGI
Primary source
MGI:MGI:2151929
See related
Ensembl:ENSMUSG00000074870 AllianceGenome:MGI:2151929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1600000I23Rik
Summary
Predicted to enable several functions, including collagen binding activity; fibronectin binding activity; and serpin family protein binding activity. Predicted to be involved in several processes, including collagen catabolic process; proteolysis; and viral entry into host cell. Predicted to be located in Golgi apparatus; multivesicular body; and plasma membrane. Predicted to be active in extracellular space and lysosome. Is expressed in extraembryonic component; labyrinthine zone; and placenta. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 161.1) See more
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Genomic context

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Location:
13 B2; 13 32.74 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61712444..61717984, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (61564630..61570170, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7756 Neighboring gene cathepsin M Neighboring gene STARR-seq mESC enhancer starr_34751 Neighboring gene predicted gene, 21933 Neighboring gene predicted gene, 20599

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Peg3 mutational effects on reproduction and placenta-specific gene families. Kim J, et al. PLoS One, 2013. PMID 24391757, Free PMC Article
  2. Transient reduction of placental angiogenesis in PAI-1-deficient mice. Labied S, et al. Physiol Genomics, 2011 Feb 24. PMID 21119013
  3. Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13. Deussing J, et al. Genomics, 2002 Feb. PMID 11829493
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC117532

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cathepsin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026906.3 → NP_081182.2  cathepsin 3 precursor

    See identical proteins and their annotated locations for NP_081182.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY034574, BY034262
    Consensus CDS
    CCDS36695.1
    UniProtKB/TrEMBL
    Q91ZD5, Q9DAZ8
    Related
    ENSMUSP00000058359.8, ENSMUST00000054702.9
    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:115 → 330
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

  2. NM_054092.2 → NP_473433.2  cathepsin 3 precursor

    See identical proteins and their annotated locations for NP_473433.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is alternatively spliced in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK005389, AY034574, BY035057
    Consensus CDS
    CCDS36695.1
    UniProtKB/TrEMBL
    Q91ZD5, Q9DAZ8
    Related
    ENSMUSP00000153399.2, ENSMUST00000223815.2
    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:115 → 330
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    61712444..61717984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517052.4 → XP_006517115.1  cathepsin 3 isoform X1

    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:115 → 257
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

  2. XM_011244465.3 → XP_011242767.1  cathepsin 3 isoform X2

    UniProtKB/TrEMBL
    Q9DAZ8
    Conserved Domains (2) summary
    smart00645
    Location:114 → 265
    Pept_C1; Papain family cysteine protease
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
Nucleotide Protein Strain
Heading Accession and Version

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