Serpinb7 serpin family B member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpinb7provided by RGD
Official Full Name: serpin family B member 7provided by RGD
Primary source: RGD:71063
See related: Ensembl:ENSRNOG00000002555 AllianceGenome:RGD:71063
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Megsin
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in positive regulation of collagen biosynthetic process; positive regulation of cytokine production; and positive regulation of glomerular mesangial cell proliferation. Predicted to be active in extracellular space. Biomarker of nephritis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINB7 (serpin family B member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 6.9), Spleen (RPKM 6.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13p11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (23884466..23956834)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (23369830..23442205)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (27282456..27354775)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

over-expression of megsin induced incorporation of [(3)H]thymidine in mesangial cells and PDGF-BB, TGF-beta1 upregulation
Title: Overexpression of megsin induces mesangial cell proliferation and excretion of type IV collagen in vitro.
high glucose per se induces megsin expression both in vivo in a model of type II diabetic nephropathy and in vitro in cultured mesangial cells, in which it also inhibits total MMP-2 and MMP-9 activities and plasmin enzymatic activity.
Title: The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix accumulation.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glomerular mesangial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of platelet-derived growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta1 production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serpin B7

Names: serine (or cysteine) peptidase inhibitor, clade B, member 7; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7; serine (or cysteine) proteinase inhibitor, clade B, member 7; serpin peptidase inhibitor, clade B (ovalbumin), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130404.2 → NP_569088.2 serpin B7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6JSV8, G3V6B5

Related

ENSRNOP00000003466.4, ENSRNOT00000003466.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

23884466..23956834

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249629.2 → XP_006249691.1 serpin B7 isoform X1

See identical proteins and their annotated locations for XP_006249691.1

UniProtKB/TrEMBL

A6JSV8, G3V6B5, Q920J5

Conserved Domains (1) summary

cl00137
Location:4 → 380

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...