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Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117182, updated on 22-Aug-2021

Summary

Official Symbol
Hsd17b3provided by RGD
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 3provided by RGD
Primary source
RGD:621805
See related
Ensembl:ENSRNOG00000019096
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
catalyzes the final step of testosterone biosynthesis in the testis [RGD, Feb 2006]
Expression
Biased expression in Testes (RPKM 5.7), Adrenal (RPKM 1.9) and 8 other tissues See more
Orthologs
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Genomic context

See Hsd17b3 in Genome Data Viewer
Location:
17p14
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (1027229..1058554)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (1579319..1610745, complement)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 367 Neighboring gene solute carrier family 35 member D2 Neighboring gene ERCC excision repair 6 like 2 Neighboring gene uncharacterized LOC102554174

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Leydig cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in biphenyl metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to gonadotropin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in hippocampus development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in insecticide metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in male genitalia development IEA
Inferred from Electronic Annotation
more info
 
involved_in organic acid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in phenol-containing compound metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to fungicide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to herbicide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insecticide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to steroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in steroid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in steroid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in testosterone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
testosterone 17-beta-dehydrogenase 3
Names
17-beta-HSD 3
17-beta-hydroxysteroid dehydrogenase type 3
17beta-HSD
estradiol 17 beta-dehydrogenase 3
estradiol 17-beta-dehydrogenase 2
testicular 17-beta-hydroxysteroid dehydrogenase
NP_446459.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054007.1NP_446459.1  testosterone 17-beta-dehydrogenase 3

    See identical proteins and their annotated locations for NP_446459.1

    Status: PROVISIONAL

    Source sequence(s)
    AF035156
    UniProtKB/Swiss-Prot
    O54939
    Related
    ENSRNOP00000025850.1, ENSRNOT00000025850.3
    Conserved Domains (2) summary
    cd05356
    Location:44281
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    pfam00106
    Location:45236
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    1027229..1058554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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