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FTSJ3 FtsJ RNA 2'-O-methyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 117246, updated on 5-Mar-2024

Summary

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Official Symbol
FTSJ3provided by HGNC
Official Full Name
FtsJ RNA 2'-O-methyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:17136
See related
Ensembl:ENSG00000108592 MIM:618411; AllianceGenome:HGNC:17136
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPB1; EPCS3
Summary
Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 14.7), lymph node (RPKM 12.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
17q23.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (63819433..63827663, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (64690280..64698513, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61896793..61905023, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 47 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61850832-61851416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8831 Neighboring gene DEAD-box helicase 42 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:61897185-61898384 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:61904136-61905335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12563 Neighboring gene proteasome 26S subunit, ATPase 5 Neighboring gene Sharpr-MPRA regulatory region 8123 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8832 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8833 Neighboring gene CRISPRi-validated cis-regulatory element chr17.4273 Neighboring gene Sharpr-MPRA regulatory region 5702 Neighboring gene testicular cell adhesion molecule 1, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression. Manning M, et al. RNA Biol, 2020 Apr. PMID 31957540, Free PMC Article
  2. FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing. Ringeard M, et al. Nature, 2019 Jan. PMID 30626973
  3. Proteomic characterization of the human FTSJ3 preribosomal complexes. Simabuco FM, et al. J Proteome Res, 2012 Jun 1. PMID 22540864
  4. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. Morello LG, et al. PLoS One, 2011. PMID 22195017, Free PMC Article
  5. MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4B(DCAF13) E3 Ligase in Osteosarcoma Cells. Chen Z, et al. Mol Ther Nucleic Acids, 2018 Mar 2. PMID 29499938, Free PMC Article

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion.
    Title: RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion.
  2. Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression.
    Title: Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression.
  3. identification of an unexpected mechanism used by HIV-1 to evade innate immune recognition: the recruitment of the TRBP-FTSJ3 complex to viral RNA and its 2'-O-methylation
    Title: FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing.
  4. Components of the FTSJ3 interactome identified by coimmunoprecipitation.
    Title: Proteomic characterization of the human FTSJ3 preribosomal complexes.
  5. The results presented in this work indicate a close functional interaction between NIP7 and FTSJ3 during pre-rRNA processing and show that FTSJ3 participates in ribosome synthesis in human cells.
    Title: The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20062

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA 2'-O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA (guanine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (uridine-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, small subunit precursor IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Names
2'-O-ribose RNA methyltransferase SPB1 homolog
FtsJ RNA methyltransferase homolog 3
FtsJ homolog 3
SPB1 RNA methyltransferase homolog
pre-rRNA processing protein FTSJ3
protein ftsJ homolog 3
putative rRNA methyltransferase 3
rRNA (uridine-2'-O-)-methyltransferase 3
NP_060117.3
XP_024306330.1
XP_054170950.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017647.4 → NP_060117.3  pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

    See identical proteins and their annotated locations for NP_060117.3

    Status: REVIEWED

    Source sequence(s)
    AF147378, AK095861, AK315010, BM914774
    Consensus CDS
    CCDS11644.1
    UniProtKB/Swiss-Prot
    B2RCA5, D3DU22, Q8IY81, Q8N3A3, Q8WXX1, Q9BWM4, Q9NXT6
    UniProtKB/TrEMBL
    B4DKU3
    Related
    ENSP00000396673.2, ENST00000427159.7
    Conserved Domains (3) summary
    COG0293
    Location:8 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
    pfam07780
    Location:644 → 834
    Spb1_C; Spb1 C-terminal domain
    pfam11861
    Location:232 → 400
    DUF3381; Domain of unknown function (DUF3381)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    63819433..63827663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450562.2 → XP_024306330.1  pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 isoform X1

    Conserved Domains (2) summary
    COG0293
    Location:8 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
    pfam11861
    Location:232 → 329
    DUF3381; Domain of unknown function (DUF3381)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    64690280..64698513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314975.1 → XP_054170950.1  pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IY81.2 GenPept UniProtKB/Swiss-Prot:Q8IY81

Gene LinkOut

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