Ank1 ankyrin 1, erythroid [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ank1provided by MGI
Official Full Name: ankyrin 1, erythroidprovided by MGI
Primary source: MGI:MGI:88024
See related: Ensembl:ENSMUSG00000031543 AllianceGenome:MGI:88024
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: nb; pale; Ank-1
Summary: Predicted to enable several functions, including enzyme binding activity; spectrin binding activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including erythrocyte development; iron ion homeostasis; and porphyrin-containing compound biosynthetic process. Located in cortical cytoskeleton; membrane; and spectrin-associated cytoskeleton. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; retina; and skeletal muscle. Used to study hereditary spherocytosis type 1 and malaria. Human ortholog(s) of this gene implicated in anemia; hereditary spherocytosis; and hereditary spherocytosis type 1. Orthologous to human ANK1 (ankyrin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 21.2), liver E14.5 (RPKM 20.5) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 11.42 cM

Exon count:: 50

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (23464852..23640517)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (22974836..23150501)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K(+) channels.
Title: Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K(+) channels.
Parasites in ankyrin-1 (Ank-1) mutation erythrocytes grew normally, but red cells showed resistance to merozoite invasion.
Title: A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice.
This study highlights the first direct examination of allelic heterogeneity of the Ank-1 gene in the context of malaria resistance in mouse models.
Title: Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria.
With increasing age (at 12-15 mo of age) extensor digitorum longus (EDL) skeletal muscles of sAnk1 KO mice develop prematurely large tubular aggregates.
Title: Deletion of small ankyrin 1 (sAnk1) isoforms results in structural and functional alterations in aging skeletal muscle fibers.
Study shows a direct interaction between beta-III spectrin and erythroid ankyrin in the cerebellum and to demonstrate a critical role for beta-III spectrin in maintaining ankyrin R throughout the Purkinje cell dendritic tree.
Title: β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees: protein complex critical for sodium channel activity is impaired by SCA5-associated mutations.
Hema6 mutation of ankyrin-1 causes hereditary spherocytosis in mice through a mild reduction of protein expression.
Title: A deep intronic mutation in the ankyrin-1 gene causes diminished protein expression resulting in hemolytic anemia in mice.
Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1-mutated mice.
Title: Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant.
We conclude that increased malaria resistance due to ankyrin-1 deficiency is caused by the intraerythrocytic death of P. chabaudi parasites.
Title: A novel ENU-mutation in ankyrin-1 disrupts malaria parasite maturation in red blood cells of mice.
These results demonstrate that mammalian erythroblast enucleation does not depend on the membrane integrity generated by the ankyrin-band 3 complex.
Title: Ankyrin and band 3 differentially affect expression of membrane glycoproteins but are not required for erythroblast enucleation.
The Ank1(E924X) strain provides a novel tool to study Ank1 and model HS.
Title: A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2)
Targeted (2) 1 citation
Chemically induced (ENU) (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ank1 (e-PCR), detects polymorphism
- UniSTS:497279

D8Rck1 (e-PCR), detects polymorphism
- UniSTS:142727

NoName (e-PCR)
- UniSTS:224946

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal anchor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal anchor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inorganic cation transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organelle organization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in A band	ISO Inferred from Sequence Orthology more info
located_in M band	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
part_of ankyrin-1 complex	ISO Inferred from Sequence Orthology more info
located_in axolemma	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in spectrin-associated cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
located_in spectrin-associated cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ankyrin-1

Names: erythrocyte ankyrin; normoblastic anemia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110783.3 → NP_001104253.1 ankyrin-1 isoform 1

See identical proteins and their annotated locations for NP_001104253.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AI846810, AK147278, AK147483, AK158131, CJ105945

Consensus CDS

CCDS52523.1

UniProtKB/TrEMBL

A0A0R4J1N7

Related

ENSMUSP00000113571.3, ENSMUST00000121802.9

Conserved Domains (8) summary

smart00218
Location:952 → 1056

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

COG0666
Location:374 → 583

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:365 → 490

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08805
Location:1442 → 1525

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:342 → 433

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:47 → 98

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:753 → 807

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:700 → 731

ANK; ANK repeat [structural motif]
NM_001277280.2 → NP_001264209.1 ankyrin-1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction in a 3' exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but lacks two alternate internal segments compared to isoform 1.

Source sequence(s)

AC126445, AI846810, AK147483, AK158131, CJ105945

Consensus CDS

CCDS72099.1

UniProtKB/Swiss-Prot

Q02357

Related

ENSMUSP00000106316.3, ENSMUST00000110688.9

Conserved Domains (8) summary

smart00218
Location:944 → 1048

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

COG0666
Location:374 → 583

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:365 → 490

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08805
Location:1434 → 1517

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:342 → 433

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:47 → 98

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:753 → 807

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:700 → 731

ANK; ANK repeat [structural motif]
NM_001277281.2 → NP_001264210.1 ankyrin-1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, represents use of an alternate promoter, initiates translation at an alternate start codon, and lacks an alternate in-frame exon compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AC126445, AI846810, AK147483, CJ101195, M84756

Consensus CDS

CCDS72100.1

UniProtKB/TrEMBL

E9QNT8

Related

ENSMUSP00000113531.2, ENSMUST00000117662.8

Conserved Domains (8) summary

smart00218
Location:907 → 1011

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

COG0666
Location:337 → 546

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:328 → 453

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08805
Location:1397 → 1480

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:305 → 396

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:10 → 61

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:716 → 770

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:663 → 694

ANK; ANK repeat [structural motif]
NM_001277284.2 → NP_001264213.1 ankyrin-1 isoform 5

See identical proteins and their annotated locations for NP_001264213.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) has an alternate 5' exon, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction in a 3' exon compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus, lacks an alternate internal segment, and contains an alternate internal segment compared to isoform 1.

Source sequence(s)

AC126445, AI846810, AK147483, BC079910, CJ101195

Consensus CDS

CCDS72101.1

UniProtKB/TrEMBL

Q0VGY9

Related

ENSMUSP00000113656.2, ENSMUST00000117296.8

Conserved Domains (8) summary

smart00218
Location:907 → 1011

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

COG0666
Location:337 → 546

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:328 → 453

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08805
Location:1397 → 1480

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:305 → 396

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:10 → 61

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:716 → 770

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:663 → 694

ANK; ANK repeat [structural motif]
NM_001277286.2 → NP_001264215.1 ankyrin-1 isoform 6

See identical proteins and their annotated locations for NP_001264215.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, represents use of an alternate promoter, initiates translation at an alternate start codon, and lacks an alternate in-frame segment compared to variant 1. The encoded isoform (6) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AI846810, AK147483, AK147597, X69063

Consensus CDS

CCDS72102.1

UniProtKB/TrEMBL

B7ZW98

Related

ENSMUSP00000133322.2, ENSMUST00000173248.8

Conserved Domains (8) summary

smart00218
Location:923 → 1027

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

COG0666
Location:345 → 554

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:336 → 461

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08805
Location:1413 → 1496

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:313 → 404

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:18 → 69

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:724 → 778

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:671 → 702

ANK; ANK repeat [structural motif]
NM_001277289.2 → NP_001264218.1 ankyrin-1 isoform 7

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, represents use of an alternate promoter compared and initiates translation at an alternate start codon to variant 1. The encoded isoform (7) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC126445, AI846810, AK147483, AK147597, X69063

Consensus CDS

CCDS72103.1

UniProtKB/TrEMBL

D3YTV8

Related

ENSMUSP00000112850.2, ENSMUST00000118733.8

Conserved Domains (8) summary

smart00218
Location:923 → 1027

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

COG0666
Location:345 → 554

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:336 → 461

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08805
Location:1413 → 1496

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:313 → 404

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:18 → 69

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:724 → 778

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:671 → 702

ANK; ANK repeat [structural motif]
NM_001310436.1 → NP_001297365.1 ankyrin-1 isoform 8

Status: VALIDATED

Description

Transcript Variant: This variant (10) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR, translation initiation at an alternate start codon, and a novel 3' coding region. The encoded isoform (8) is shorter than and has distinct N- and C-termini compared to isoform 1.

Source sequence(s)

AI846810, AK134267, AK147483, BC079910, U73972

Consensus CDS

CCDS80865.1

UniProtKB/Swiss-Prot

Q02357

UniProtKB/TrEMBL

Q0VGY9

Related

ENSMUSP00000033947.9, ENSMUST00000033947.15
NM_001310437.1 → NP_001297366.1 ankyrin-1 isoform 9

See identical proteins and their annotated locations for NP_001297366.1

Status: VALIDATED

Description

Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. It encodes isoform 9, which has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AI846810, AK147483, U73972

Consensus CDS

CCDS80864.1

UniProtKB/Swiss-Prot

Q02357

Related

ENSMUSP00000112966.2, ENSMUST00000121075.8
NM_031158.4 → NP_112435.2 ankyrin-1 isoform 2

See identical proteins and their annotated locations for NP_112435.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, represents use of an alternate promoter, initiates translation at an alternate start codon, and lacks an alternate in-frame segment compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AI846810, AK147278, AK147483, X69063

Consensus CDS

CCDS22187.1

UniProtKB/TrEMBL

G5E8J2

Related

ENSMUSP00000081051.5, ENSMUST00000084038.11

Conserved Domains (8) summary

smart00218
Location:923 → 1027

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

COG0666
Location:345 → 554

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:336 → 461

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08805
Location:1413 → 1496

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:313 → 404

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:18 → 69

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:724 → 778

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:671 → 702

ANK; ANK repeat [structural motif]

RNA

NR_102385.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR, represents use of an alternate promoter, and has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AI846810, AK147483, AK147597, X69063

Related

ENSMUST00000173573.8
NR_102386.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (9) differs in the 5' UTR, represents use of an alternate promoter, and has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AI846810, AK147483, X69063

Related

ENSMUST00000123418.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

23464852..23640517

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508990.2 → XP_006509053.1 ankyrin-1 isoform X2

Conserved Domains (9) summary

smart00218
Location:952 → 1056

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:415 → 625

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:123 → 468

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1442 → 1525

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:700 → 731

ANK; ANK repeat [structural motif]

pfam12796
Location:49 → 140

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:767 → 819

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1277 → 1406

UPA_2; UPA domain

cl39094
Location:579 → 792

Ank_2; Ankyrin repeats (3 copies)
XM_006509000.2 → XP_006509063.1 ankyrin-1 isoform X12

UniProtKB/TrEMBL

D3Z5M4

Related

ENSMUSP00000113495.3, ENSMUST00000117270.9

Conserved Domains (9) summary

smart00218
Location:952 → 1056

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:415 → 625

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:123 → 468

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1442 → 1525

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:700 → 731

ANK; ANK repeat [structural motif]

pfam12796
Location:49 → 140

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:767 → 819

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1277 → 1406

UPA_2; UPA domain

cl39094
Location:579 → 792

Ank_2; Ankyrin repeats (3 copies)
XM_006508989.4 → XP_006509052.1 ankyrin-1 isoform X1

Conserved Domains (9) summary

smart00218
Location:970 → 1074

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1460 → 1543

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1295 → 1424

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006508991.5 → XP_006509054.1 ankyrin-1 isoform X3

Conserved Domains (9) summary

smart00218
Location:970 → 1074

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1460 → 1543

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1295 → 1424

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006508992.5 → XP_006509055.1 ankyrin-1 isoform X4

Conserved Domains (9) summary

smart00218
Location:970 → 1074

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1460 → 1543

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1295 → 1424

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006508997.5 → XP_006509060.1 ankyrin-1 isoform X9

Conserved Domains (9) summary

smart00218
Location:970 → 1074

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1460 → 1543

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1295 → 1424

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006508993.5 → XP_006509056.1 ankyrin-1 isoform X5

Conserved Domains (9) summary

smart00218
Location:970 → 1074

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1460 → 1543

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1295 → 1424

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_030243250.2 → XP_030099110.1 ankyrin-1 isoform X13

Conserved Domains (9) summary

smart00218
Location:970 → 1074

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1460 → 1543

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1295 → 1424

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006508994.5 → XP_006509057.1 ankyrin-1 isoform X6

Conserved Domains (9) summary

smart00218
Location:970 → 1074

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1460 → 1543

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1295 → 1424

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006508998.5 → XP_006509061.1 ankyrin-1 isoform X10

Conserved Domains (9) summary

smart00218
Location:970 → 1074

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1460 → 1543

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1295 → 1424

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006509001.5 → XP_006509064.1 ankyrin-1 isoform X14

Conserved Domains (9) summary

smart00218
Location:970 → 1074

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1460 → 1543

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1295 → 1424

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006508995.5 → XP_006509058.1 ankyrin-1 isoform X7

Related

ENSMUSP00000117966.3, ENSMUST00000141784.9

Conserved Domains (9) summary

smart00218
Location:962 → 1066

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1452 → 1535

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1287 → 1416

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006508999.5 → XP_006509062.1 ankyrin-1 isoform X11

Conserved Domains (9) summary

smart00218
Location:962 → 1066

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1452 → 1535

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1287 → 1416

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006509002.5 → XP_006509065.1 ankyrin-1 isoform X15

Conserved Domains (9) summary

smart00218
Location:962 → 1066

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1452 → 1535

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1287 → 1416

UPA_2; UPA domain

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006509003.5 → XP_006509066.1 ankyrin-1 isoform X16

Conserved Domains (7) summary

smart00218
Location:970 → 1074

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:433 → 643

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:141 → 486

PHA02876; ankyrin repeat protein; Provisional

sd00045
Location:718 → 749

ANK; ANK repeat [structural motif]

pfam12796
Location:67 → 158

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:785 → 837

Ank_4; Ankyrin repeats (many copies)

cl39094
Location:597 → 810

Ank_2; Ankyrin repeats (3 copies)
XM_006508996.3 → XP_006509059.1 ankyrin-1 isoform X8

Conserved Domains (9) summary

smart00218
Location:923 → 1027

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02875
Location:386 → 596

PHA02875; ankyrin repeat protein; Provisional

PHA02876
Location:94 → 439

PHA02876; ankyrin repeat protein; Provisional

cd08805
Location:1413 → 1496

Death_ank1; Death domain of Ankyrin-1

sd00045
Location:671 → 702

ANK; ANK repeat [structural motif]

pfam12796
Location:20 → 111

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:738 → 790

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1248 → 1377

UPA_2; UPA domain

cl39094
Location:550 → 763

Ank_2; Ankyrin repeats (3 copies)
XM_036153729.1 → XP_036009622.1 ankyrin-1 isoform X17