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Anp32a acidic nuclear phosphoprotein 32 family member A [ Mus musculus (house mouse) ]

Gene ID: 11737, updated on 21-Apr-2024

Summary

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Official Symbol
Anp32aprovided by MGI
Official Full Name
acidic nuclear phosphoprotein 32 family member Aprovided by MGI
Primary source
MGI:MGI:108447
See related
Ensembl:ENSMUSG00000032249 AllianceGenome:MGI:108447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LANP; pp32; Anp32; PHAP1; I1PP2A
Summary
Predicted to enable histone binding activity. Predicted to be involved in nucleocytoplasmic transport and regulation of apoptotic process. Located in nuclear matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to several human genes including ANP32A (acidic nuclear phosphoprotein 32 family member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 178.7), CNS E14 (RPKM 62.2) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 33.68 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (62248637..62286084)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62341343..62378804)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S16 pseudogene Neighboring gene predicted gene, 35288 Neighboring gene STARR-seq mESC enhancer starr_24372 Neighboring gene STARR-positive B cell enhancer ABC_E6749 Neighboring gene predicted gene, 20346 Neighboring gene predicted gene, 40522 Neighboring gene STARR-seq mESC enhancer starr_24378 Neighboring gene VISTA enhancer mm210 Neighboring gene predicted gene, 40523

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals. Liang L, et al. mBio, 2019 Jun 18. PMID 31213560, Free PMC Article
  2. Inhibition of Histone Acetylation by ANP32A Induces Memory Deficits. Chai GS, et al. J Alzheimers Dis, 2018. PMID 29782322
  3. Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model. Chai GS, et al. Mol Neurodegener, 2017 May 4. PMID 28472990, Free PMC Article
  4. The expression and distributions of ANP32A in the developing brain. Wang S, et al. Biomed Res Int, 2015. PMID 25866766, Free PMC Article
  5. Generation and characterization of LANP/pp32 null mice. Opal P, et al. Mol Cell Biol, 2004 Apr. PMID 15060138, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A.
    Title: PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A.
  2. Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus.
    Title: Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus.
  3. Hypoxia and Wnt signaling inversely regulate expression of chondroprotective molecule ANP32A in articular cartilage.
    Title: Hypoxia and Wnt signaling inversely regulate expression of chondroprotective molecule ANP32A in articular cartilage.
  4. ANP32A/ATM axis discovered in cartilage is also present in brain and bone.
    Title: ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone.
  5. The findings of this study reveal that upregulated ANP32A induced-suppressing histone acetylation may underlie the cognitive decline in neurodegenerative disease.
    Title: Inhibition of Histone Acetylation by ANP32A Induces Memory Deficits.
  6. our study reveals that ANP32A dysregulation may be a critical factor contributing to acute megakaryoblastic leukemia
    Title: ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia.
  7. We conclude that downregulating ANP32A rescues synaptic plasticity and memory ability by reducing INHAT formation and unmasking histone for hyperacetylation
    Title: Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model.
  8. The variation of expression levels and distribution of ANP32A in the developing brain would imply that ANP32A may play an important role in mammalian brain development
    Title: The expression and distributions of ANP32A in the developing brain.
  9. depleting the Leucine-rich Acidic Nuclear Protein (LANP)-an ATXN1 binding inhibitor of histone acetylation-reverses aspects of Spinocerebellar ataxia type 1 neuritic pathology.
    Title: LANP mediates neuritic pathology in Spinocerebellar ataxia type 1.
  10. LANP directly regulates expression of the neurofilament light chain, an important neuron-specific cytoskeletal gene, by binding to the promoter of this gene and modulating histone acetylation levels
    Title: Neuronal differentiation is regulated by leucine-rich acidic nuclear protein (LANP), a member of the inhibitor of histone acetyltransferase complex.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleocytoplasmic transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acidic leucine-rich nuclear phosphoprotein 32 family member A
Names
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
acidic nuclear phosphoprotein 32
acidic nuclear phosphoprotein pp32
leucine-rich acidic nuclear protein
potent heat-stable protein phosphatase 2A inhibitor I1PP2A
vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411151.1 → NP_001398080.1  acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113291, AC121813

  2. NM_001411152.1 → NP_001398081.1  acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113291, AC121813
    UniProtKB/TrEMBL
    D3Z7M9
    Related
    ENSMUSP00000122165.2, ENSMUST00000135395.8

  3. NM_009672.4 → NP_033802.2  acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 1

    See identical proteins and their annotated locations for NP_033802.2

    Status: VALIDATED

    Source sequence(s)
    AC113291, AC121813
    Consensus CDS
    CCDS40663.1
    UniProtKB/Swiss-Prot
    O35381, P97437
    Related
    ENSMUSP00000082652.7, ENSMUST00000085519.13
    Conserved Domains (3) summary
    sd00035
    Location:90 → 113
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam14580
    Location:71 → 146
    LRR_9; Leucine-rich repeat
    NF033189
    Location:9 → 128
    internalin_A; class 1 internalin InlA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    62248637..62286084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35381.1 GenPept UniProtKB/Swiss-Prot:O35381

Gene LinkOut

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